• List of Articles sedation

      • Open Access Article

        1 - Comparative study of sedation and pre-anesthetic effects of polar, semi polar and non-polar fractions of vinca minor extract in comparison with midazolam in rat
        A. Rezaei, E. Issabeagloo, مهرداد Pashazadeh, .
        Periwinkle is a plant known as a Vinca minor in Persian. This plant contain bitter substancecalled Vincine, Tannin, Pectin, Carotene, vincamine Alkaloids, Vinci nine, Catarin, and a kindof Saponin and large amount of Vinine Alkaloids and Pubcine. All parts of this plant More
        Periwinkle is a plant known as a Vinca minor in Persian. This plant contain bitter substancecalled Vincine, Tannin, Pectin, Carotene, vincamine Alkaloids, Vinci nine, Catarin, and a kindof Saponin and large amount of Vinine Alkaloids and Pubcine. All parts of this plant can beused; especially the leaves that can be picked in any season and seared by heat. The purpose ofthis study is evaluating sedation and pre-anesthetic effects of polar fractions, semi polar andnon-polar of Vinca minor plant in comparison with midazolam found in rats. 60 Wistar rat headin different groups is applied in these tests. Three polar, semi-polar, and non-polar fractions and0.04 mg/kg dose of midazolam and dimethyl sulfoxide (DMSO) with equal volume aretransfused into peritoneum as a drug, half an hour before experiment. In a test the sedation andpre-anesthetic induction time and sleeping time effects are surveyed by seconds and recorded bychronometer. Findings show that in medical team the mentioned doses of extract meaningfulboth in infused dream by ketamine and increase in life time (p<0.01). According to sedationand pre-anesthetic effects of this plant, studies indicate that polar fraction of Vinca minor with100 mg/kg dose has sedation, pre-anesthetic effects. Manuscript profile
      • Open Access Article

        2 - Evaluation of the Analgesic and Sedative Effects of Pethidine (meperidine)with Xylazine in the Horse
        Pouyan, M., Ozmaie, S., Sakha, M., Asghari, A. .
        A variety of analgesic and sedative agents are available, and which one can be used in horses is a highly controversial issue. The purpose of this study was to evaluate the analgesic and sedative effects and effect on vitalsigns and probable side effects of ad More
        A variety of analgesic and sedative agents are available, and which one can be used in horses is a highly controversial issue. The purpose of this study was to evaluate the analgesic and sedative effects and effect on vitalsigns and probable side effects of administered pethidine with xylazine in the horse. Ten healthy mix breed horses 2-8 years of age, weighing 250-350 kg were randomly divided into two groups. A treatment group received combination of pethidine (2 mg/kg, IM) and xylazine (0/2 mg/kg, IV). The second control group received a saline placebo (1ml/45 kg bwt, IV). Heart rate, respiratory rate and rectal temperature were recorded. The records were averaged for the fifteen minutes’ intervals to 6 hours after injection. Analgesia was assessed with pin prick in the tail and perineal region. Data were analyzed statistically by two way of analysis of variance (ANOVA) using repeated measurements and Duncan’s multiple range tests to determine significant differences using P0.05) above baseline in the treatment group at 30 and 60 minutes after injection. Rectal temperature decreased from baseline values in treatment group at 15minutes after injection. The lowest recorded rectal temperature in the treatment group was 35.92 ± 0.3at 15 minutes and returned toward baseline in treatment groups 30 minutes after injection. Respiratory rate in the treatment group significantly decreased following administration at 15 and 30 min compared with the control group. Results of this study showed that parenteral administration of pethidine with xylazine is fast-acting and effective sedation in animals are created while pethidine it is not effective for analgesia and side effects from this combination is acceptable and does not cause any danger to the animal. Manuscript profile
      • Open Access Article

        3 - Evaluation of the clinical, analgesic and Sedative Effects of tramadol with acepromazine in the Horse
        Fadaeifar, R., Asghari, A., Ozmaie, S., Sakha, M. .
        A variety of analgesic and sedative agents are available, and which one can be used in horses is a highly controversial issue. The purpose of this study was to evaluate the analgesic and sedative effects and effect on vital signs and probable side effects of a More
        A variety of analgesic and sedative agents are available, and which one can be used in horses is a highly controversial issue. The purpose of this study was to evaluate the analgesic and sedative effects and effect on vital signs and probable side effects of administered tramadol with acepromazine in the horse. Ten healthy mix breed horses 2-10 years of age, weighing 250-350 kg were randomly divided into two groups. One group received combination of tramadol (1 mg/kg, IV) and acepromazine (0/05 mg/kg, IV). The second control group received a saline placebo (1ml/45 kg bwt, IV). Heart rate, respiratory rate rectal temperature, systolic and diastolic blood pressure and GI movement were recorded. The records were averaged for the fifteen minutes’ intervals to 6 hours after injection. Analgesia was assessed with pin prick in the tail and perineal region. Data were analyzed statistically by two way of analysis of variance (ANOVA) using repeated measurements and Duncan’s multiple range tests to determine significant differences using P<0.05. In this study tramadol with acepromazine show good sedation but have no analgesic effects. The mean of temperature degree, respiratory rate, heart rate, systolic and diastolic blood pressure and GI movement in the treatment group at the time of 0, 15, 30, 60 and 360 minute did not show significant difference with the control group. Results of this study showed that parenteral administration of tramadol with acepromazine is fast and effective sedation in animals are created and no significant changes in vital signs and does not cause any danger to the animal although it does not reduce pain. Manuscript profile
      • Open Access Article

        4 - Camel; sedation, induction and maintenance of anesthesia; A review article
        Abolfazl Barzegar Bafrouei Moosa Javdani
        Abstract Anesthetics are used for a variety of reasons, such as to minimize or eliminate pain, relax muscles and even to facilitate clinical examination and diagnostic procedures. like other ruminants in camels, most of the surgical interventions are performed with loc More
        Abstract Anesthetics are used for a variety of reasons, such as to minimize or eliminate pain, relax muscles and even to facilitate clinical examination and diagnostic procedures. like other ruminants in camels, most of the surgical interventions are performed with local anesthesia and sedative. Different anesthetic regimens in practice for other animals also hold true in the camel..the most common drugs used for premedication/ sedation in camels were xylazine, romifidine, detomidine, medetomidine, tramadol and butorphanol. For induction and maintenance of anaesthesia, the following drugs were used most commonly: propofol, ketamine, xylazine- ketamine, ketamine-romifidine-diazepam, medetomidine-ketamine, propofol-xylazine, propofol-xylazine-diazepam, tramadol-xylazine, medetomidine-ketamine, medetomidine-ketamine-butorphanol and midazolam-propofol. The drugs used to reverse the effects of analgesia were atipamezole and natrelexone. The objectives of this article were to review all scientific data regarding anaesthetic drugs and anaesthetic protocols used for pre-medication, sedation, induction and maintenance of anaesthesia in camels (Camelus dromedarius) in the field was published 2008-2015.The effective doses and reported side effects were discussed. Manuscript profile