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Open Access Article
1 - Dietary pattern and risk of prostate cancer
جمال رحمانی محمد عطاییFactor analysis was conducted over two dietary patterns were identified. Western dietary pattern with high consumption of sweets, jams and preserves, mayonnaise, soft drinks, salty snacks, solid fats, high fat dairy products, fried potatoes, Ama’ and viscera, meat MoreFactor analysis was conducted over two dietary patterns were identified. Western dietary pattern with high consumption of sweets, jams and preserves, mayonnaise, soft drinks, salty snacks, solid fats, high fat dairy products, fried potatoes, Ama’ and viscera, meat and processed foods, tea and coffee , a healthy diet with a higher intake of refined grains and cooking oils, legumes, nuts, fruits, poultry and fish, whole grains, eggs, vegetables and low-fat dairy Bvd.ps adjusting for the impact of possible turbulence earn higher scores the Western pattern diet significantly (P <0.05) were associated with increased risk of prostate cancer (odds ratio 2.33; 95% CI, 9/4 to 1/1) in front earn a high score of a healthy diet significant relationship (P <0.05) with a reduced risk of prostate cancer (OR = odds of 25/0, 95%, 53/0 to 11/0). lower risk of prostate cancer.People with a diet rich in refined grains close to the Western dietary pattern, red and processed meat and high-fat and fried food more risk of prostate cancer versus those who risk their diet is closer to a healthy diet lower risk of prostate cancer. Manuscript profile -
Open Access Article
2 - Evaluation of ZEB1 gene expression in cancerous and benign tissue of human prostate cancer
fahimeh baghbani-arani behnaz karimi azadeh shojaeeMetastatic Prostate cancer is a lethal disease, but unfortunately the molecular mechanisms that underlie the metastasis of this common cancer are still poorly understood. In advanced stages of the cancer, cells cancerous may spread to the other part of the body speciall MoreMetastatic Prostate cancer is a lethal disease, but unfortunately the molecular mechanisms that underlie the metastasis of this common cancer are still poorly understood. In advanced stages of the cancer, cells cancerous may spread to the other part of the body specially to bones and lymph nodes. One of the important contributing processes in cancer invasion and metastasis is Epithelial to Mesenchymal Transition (EMT). Overexpression of ZEB1 as a key regulating factor, promotes EMT processes in a variety of cancers. In the present study, to evaluate the expression of ZEB1 and its differences between benign prostate hyperplasia and prostate cancer, 16 patients with BPH and 17 patients with Pca were selected, RNA was extracted and after synthesis of cDNA , ZEB1 expression in mRNA level was analyzed by Real Time PCR. Our results indicated that ZEB1 was overexpressed in Pca samples in comparison to BPH ones (P=0.047). In conclusion our findings suggest that evaluating the expression of ZEB1 is likely to be useful as a prognostic biomarker to diagnose prostate cancer in early stages. Furthermore, due to the critical role of ZEB1 in metastasis promotion of a variety of cancers through regulating other EMT markers, it would be possible to avoid progression and metastasis of prostate cancer by suppressing ZEB1. Manuscript profile -
Open Access Article
3 - The cytotoxic effect of Spirulina extract on gastric and prostate cancer cell lines
F. Khodaverdipour Ali SharifzadehThe AGS cell line contains gastric cancer cells, which are among the most common cancers in the world. The DU145 cell line also includes prostate cancer cells, the second leading cause of death in men after lung cancer. This study was designed to assess the cytotoxicity MoreThe AGS cell line contains gastric cancer cells, which are among the most common cancers in the world. The DU145 cell line also includes prostate cancer cells, the second leading cause of death in men after lung cancer. This study was designed to assess the cytotoxicity of spirulina extract on AGS and DU145 cell lines. In this in vitro trial, cell lines AGS and DU145 were used. Gastric and prostate cancer cell lines were prepared and cultured from the Iranian Center for Biological and Genetic Resources. The cells were divided into treatment and control groups. The effect of spirulina extract on the treated group was determined using the MTT method. According to MTT results, Spirulina extract has anti-cancer activity and more than 50% reduction in cell density against AGS and DU145 cell lines; While it did not show any significant effect on healthy cells (P< 0.05). The results of this study indicate that Spirulina extract has a good potential to control cancer cells. Manuscript profile -
Open Access Article
4 - Investigate of miR-21 expression level in urine samples of people with prostate cancer
Alireza Emamvirdizadeh mehrdad hashemi franak jamshidianIntroduction: Prostate cancer is the most common cancer in men A group of diagnostic biomarkers is MicroRNA, they can be used to diagnose variable diseases, especially cancers. this study, we investigate changes in the expression level of miR-21 in urine, in people with MoreIntroduction: Prostate cancer is the most common cancer in men A group of diagnostic biomarkers is MicroRNA, they can be used to diagnose variable diseases, especially cancers. this study, we investigate changes in the expression level of miR-21 in urine, in people with prostate cancer and healthy group. Materials and methods: This research was done on 70 urine samples of prostate cancer patients (32 Metastatic and 38 Non-metastatic) and 30 control samples with negative biopsy report. First RNA was extracted with Trizol, after the cDNA synthesis, changes in the expression of miR-21 and miR-214 in the urine of people with prostate cancer and healthy group were investigated by using Real-time PCR. Statistical analysis of data was calculated with REST 2009. Results: The results revealed the presence of miR-21 in urine samples in patients with prostate cancer, and it was found that miR-21 showed a significant increase in expression (P=0.003) than healthy group. miR-21 in metastatic group (P=0.042) demonstrate over expression than non-metastatic group (P=0.036). Conclusions: The results show that, miR-21 has significant change in expression level in patients with prostate cancer in compare of healthy group, and can be a non-invasive method to detect prostatic patients and also use this biomarker to determine metastatic and non-metastatic group. Manuscript profile -
Open Access Article
5 - Investigation of miR-25 expression level in urine samples of people with prostate cancer
Alireza Emamvirdizadeh ملیحه انتظاری Saghi Nooraei Faranak Jamshidian Hamidreza GholamrezaeiIntroduction: After breast cancer, prostate cancer is the most common cancer in men. Screening is recommended by examining prostate-specific antigen levels and performing accurate rectal tests, but there are still problems with the specificity and sensitivity of these t MoreIntroduction: After breast cancer, prostate cancer is the most common cancer in men. Screening is recommended by examining prostate-specific antigen levels and performing accurate rectal tests, but there are still problems with the specificity and sensitivity of these tests. A group of diagnostic biomarkers are microRNAs, a class of small non-coding RNAs that play a broad regulatory role in molecular signaling pathways in the cell. The aim of this study was to investigate the changes in the expression level of miR-25 in the urine of patients with prostate cancer (metastatic and non-metastatic groups) and healthy individuals.Materials and methods: 70 urine samples from prostate cancer patients (32 metastatic and 38 non-metastatic) and 30 from healthy subjects with negative biopsy reports were collected. RNA was extracted with Trizol, after the cDNA synthesis, the expression level of miR-25 in the urine was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Statistical analysis of data was calculated with REST 2009.Results: The results showed that miR-25 significantly reduced expression in patients with prostate cancer compared with healthy individuals (P = 0.001). Also, miR-25 in the metastatic group (p = 0.002) had a lower expression than the non-metastatic group (p = 0.045) compared to healthy individuals.Conclusions: The results of this study showed that miR-25 had a significant decrease in expression in patients with prostate cancer compared to healthy individuals, which with further studies is hoped to be able to diagnose patients with prostate cancer and even distinguish metastatic and non-metastatic groups. Manuscript profile -
Open Access Article
6 - Inhibitory effects of Behind the scenes medicine extract (Physalis alkekengi) on prostate cancer caused by DMBA injection in mice
Maryam Teimouri fariba khosravinejadIntroduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extra MoreIntroduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extract on prostate cancer. In this study, we evaluated the therapeutic effects of hydroalcoholic extract of Physalis alkekengi extract on prostate cancer induced by injection of 12.7-dimethylbenzanthracene (DMBA) (a carcinogenic drug) on mouse modelMaterials and Methods: After induction of anesthesia, DMBA was injected directly into the prostate gland of male rats and after 14 days, rats received different amounts of puppet extract every 48 hours and by the end of day 21, intraperitoneal injection of puppet extract. In the control group, intraperitoneal injection of normal saline was performed.Results: The results showed that the puppet extract significantly reduced prostate weight, especially at two concentrations (100 mg, 500, and 1000). Histopathological changes were also observed in the prostate tumors of p.alkekengi extract treated groups compared to the control group.Conclusion: It is suspected that the hydroalcoholic extract of the p.alkekengi inhibits abnormal growth, precancerous lesions, and DMBA-induced carcinoma in the BALB / c mouse prostate. Manuscript profile -
Open Access Article
7 - Investigating the combined effect of endostatin along with endometrial stem cells expressing TSP-1 anti-angiogenic gene on angiogenic induce factors on the treatment of prostate cancer in rats
hossein Attar shakeri Esmail Fattahi Mohammadreza Nowroozi Seyed Ali Momeni Abbas PiryaiProstate cancer is the second leading cause of cancer deaths in men. Androgen ‎deprivation therapy has been identified to induce oxidative stress in prostate cancer, ‎leading to reactivation of androgen receptor (AR) signaling. Thus, antioxidant therapies ‎h MoreProstate cancer is the second leading cause of cancer deaths in men. Androgen ‎deprivation therapy has been identified to induce oxidative stress in prostate cancer, ‎leading to reactivation of androgen receptor (AR) signaling. Thus, antioxidant therapies ‎have gained attention as adjuvants for this cancer. Here, we report for the first time that ‎endostatin along with endometrial stem cells expressing TSP-1 anti-angiogenic gene ‎improved androgen- phenotype and genotype in rats prostate cancer cells.‎‏ ‏Forty male ‎rats (n=8) weighing approximately 95-100 g were purchased from Pasteur Inistitute of ‎Tehran . Animals were suffered to prostate cancer by injecting LNCaP cell line for 12 ‎weeks. Prostate cancer animals were immediately received endostatin for 28 days. ‎Prostate cancer animals were received stem cell containing the Tsp-1 anti-angiogenesis ‎gene. Histological examinations were measured. The levels of IL8 and VEGF serum ‎were assayed.‎‏ ‏In group receiving cells and drug, amount and height of acinus wall folds ‎decreased compared to the patient group and the shape of the vesicles was clear and the ‎epithelial lining were cohesive and regular. The levels of IL8 and VEGF serum were ‎significantly decreased in combination group than to prostate cancer group (P≤0.01). ‎ Manuscript profile -
Open Access Article
8 - The Effect of a NSAID Drug on the Expression of Inflammatory Genes in Prostate Cancer Cells
Fatemeh Moghbeli Mohammad Morad Farajollahi Abbas Mirshafiey Monireh MohsenzadeganInflammation is a physiological process begining with tissue damage in the presence of various infectious agents, and men with symptoms of chronic inflammation in their noncancerous prostate tissue are about twice as likely as other men to develop advanced prostate canc MoreInflammation is a physiological process begining with tissue damage in the presence of various infectious agents, and men with symptoms of chronic inflammation in their noncancerous prostate tissue are about twice as likely as other men to develop advanced prostate cancer. Considering the importance of inflammatory factors in the invasion and metastasis of prostate cancer cells, we decided to evaluate the effect of the anti-inflammatory drug M2000 on two inflammatory genes involved in the invasion of cancer cells. PC3 cells were first cultured using RPMI medium with 10% FBS and 1% PenStrep. The cells were then treated with M2000 at concentrations of 25 and 50 μg/ml and after 24 hours the expression of il-8 and NF-κB were examined using real-time RT-PCR. NF-κB was assessed using real-time RT-PCR. In this study, NF-κB gene expression decreased in all treatments in RT-PCR. While the il-8 decreases in expression at a concentration of 50 μg/ml. The results of the present study showed that M2000 can reduce the expression of il-8 and NF-κB genes involved in tumorigenesis and invasion of prostate cancer cells, which could pave the way for future studies to better control prostate cancer. Manuscript profile
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