List of Articles physalis alkekengi

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  1 - Study Of Cytotoxisity Effects Of Aqueous Extract Of Physalis. alkekengi Against U937 Cell Line
  Parvin Torabzadeh Mahroz Dezfulian
  Introduction and Objective:Physalis-alkekengiof Solanaceace has been recommended as a traditional antipyretic, antineoplastic, anti inflammation, analgestic, anti bacterial, anti virus and anti tumor drug by herbalist in Iran. For this purpose we decided to study cytoto More

  Introduction and Objective:Physalis-alkekengiof Solanaceace has been recommended as a traditional antipyretic, antineoplastic, anti inflammation, analgestic, anti bacterial, anti virus and anti tumor drug by herbalist in Iran. For this purpose we decided to study cytotoxic effects of the aqueous extract of it on the U937 Cell.Materials and Methods:At first, the aqueous extracts of the plant were obtained. Then three different doses of this extract (low, medium and high) were effected on U937, Hela and L929 cell cultures, and by MTT Assay viability of this cells were evaluated.Results:The results show that significant difference was observed in surviving of U937, Hela and L929 cells, when control group and treated group was compared.The LC50 for the U937 cells was28.125 mg/ml.ConclusionThe results discovered that aqueous extracts of the Physalis-alkekengi have good cytotoxic effects on U937 cells. Manuscript profile
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  2 - Effects Of Aqueous Extract Of Physalis alkekengi Fruits on Development Of Balb/C Mouse Embryos
  Parvin Torabzadeh Mahsa Ghosi Kazem Parivar
  Inroduction and ObjectiveThe aqueous extract of Winter cherry fruits (Physalis-alkekengi; solanacea) has long been recommended as a traditional contraceptive drug by herbalists in Iran. For this purpose we decided to study the biological effects of the aqueous extract o More

  Inroduction and ObjectiveThe aqueous extract of Winter cherry fruits (Physalis-alkekengi; solanacea) has long been recommended as a traditional contraceptive drug by herbalists in Iran. For this purpose we decided to study the biological effects of the aqueous extract of it on the histogenesis and organogenesis of developing Balb/C mouse embryos.Materials and Methods:Intra peritoneal injections of aqueous extract were applied in all experiments. LD50 standard was determined 20.6 g/kg of body weight in vivo conditions.Results: Results of day 4 gestation showed exohepatic, exohepatic together with spinabifida, 1.58% exencephal, 27% limb malformation and 1.58 fused placenta. Results of day 5 gestation revealed 13.6% with polyps in hand. Results of day 6 gestation produced 9.72% polyps in the hands and 16.7% some embryos with hemorrhage in chest, back, face and skull. Also one of the experimental placenta showed a circle of hemorrhage around umbilical cord (1.62%).Conclusion:We conclude that probably physalin F is the main teratogenic agent in this species of plant, but there remain more to be done in this respect Manuscript profile
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  3 - The effect of different concentrations of cytokinin and auxin on in vitro culture of Physalis alkekengi (L.) using leaf and stem explants
  Mona Kashanchi Elaheh Pourfakhraei Mitra Parsa Amineh Zeinali
  10.30495/iper.2022.1952442.1772
  Physalis alkekengi is a fruit-bearing plant in Iran. It is very popular due to the nutritional and medicinal properties. The main limitations of its cultivation are short reproductive cycle, fruits susceptibility to pests and limited information about crop management. T More

  Physalis alkekengi is a fruit-bearing plant in Iran. It is very popular due to the nutritional and medicinal properties. The main limitations of its cultivation are short reproductive cycle, fruits susceptibility to pests and limited information about crop management. The use of different micropropagation methods to produce physalis is proposed as practical solution. This study was conducted to evaluate the effect of culture medium and different concentrations of growth regulators on the seeds germination and organogenesis of P. alkekengi by using tissue culture technique as well as providing a suitable protocol for in vitro micropropagation of this plant. Seeds were cultured in 1/2 MS and distilled water with three different stabilizers including Plant Agar, Sand and Filter Paper. Direct regeneration (stem) and indirect regeneration (callusing from stem and leaf explants) were used for regeneration of the physalis. Explants were cultured in different hormone combinations of 6-Benzylaminopurine (BAP in 2 and 3 mg/L) and 2, 4-Dichlorophenoxyacetic acid (2, 4-D) (2 mg/L). The best seed germination medium was 1/2 MS contains plant agar as stabilizer (95%). The best explant for callusing was leaf and the best medium was ½ MS containing 2, 4-D (2 mg/ L). The best regeneration medium was BAP (3 mg / L) + GA3 (0.5 mg / L) on MS 1/2. The best hormone for direct organogenesis of stem was BAP at different concentrations. The best medium for micropropagation was ½ MS containing BAP (3 mg / L) + GA3 (0.5 mg / L) (more than 25 seedlings per explant). Rooting was performed using IBA (150 mg / L) followed by transferring seedlings to ½ MS after one week. Finally, seedlings were easily transferred to the soil and more than 95% of them survived in the greenhouse. These results suggest a protocol for commercial micropropagation of physalis plants. Manuscript profile
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  4 - Phytochemical response of physalis alkekengi L. to foliar application of amino acids.
  Sirous Saremi Manouchehr Gholipoor Hamid Abbasdokht Hassanali Naghdi Badi Ali Mehrafarin Hamid reza Asghari
  10.30495/ejmp.2021.694469
  Biostimulants originate from natural and biological sources and in addition to improving plant growth and soil yield, they can protect plants from environmental stresses and stimulate the synthesis of secondary metabolites involved in plant defense mechanism. In this st More

  Biostimulants originate from natural and biological sources and in addition to improving plant growth and soil yield, they can protect plants from environmental stresses and stimulate the synthesis of secondary metabolites involved in plant defense mechanism. In this study, to study the effect of foliar application of various amino acids on the biochemical responses of Physalis alkekengi L. an experiment in the form of randomized complete block design with 3 replications in the farm of research Institute of Medicinal Plants of jahad University in Karaj was conducted in the cropping year of 2018-19.Treatments at five levels of amino acid foliar application including {control (A0), tryptophan (1 mg/L) (A1), glycine (1 mg/L) (A2), tyrosine (1 mg/L) (A3) and arginine (1 mg/L) (A4) were administered. Measured variables included: carotenoids, anthocyanins, proline, phenol, beta-carotene, lycopene, ascorbic acid, and alkaloids. The dimensions of the plots were 3×3 m, the distance between each plot was considered to be one meter. Planting operations were done manually in May 2017. The distance between the plants on the culture lines was 25 cm and the distance between the culture lines was 60 cm. Foliar spraying on plants began before flowering. At the time of sampling, three replicates were taken from each treatment and three samples were taken from each replication. Chlorophyll and carotenoids by Lichtenthaler method, anthocyanin by Mita method, proline by Bates method, phenol by Meda method, beta-carotene by Amarowicz method, lycopene by Montesano method, ascorbic acid by titration method, and alkaloid by Iranian Herbal Pharmacopeia method, were measured. The results showed that foliar application of amino acids had a significant effect (p ≤ 0.01) on all evaluated traits and the highest amounts of carotenoids (12.83 mg/gfw), beta-carotene (0.035 mg/gfw), and lycopene (0.017 mg/gfw) from arginine foliar application, highest ascorbic acid (24.2 mg/gfw) and alkaloids (42.25%) from tryptophan foliar application, highest proline (1.4 mg/gfw) Glycine and the highest levels of anthocyanin (12.25 mg/gdw) and phenol (32.44 mg/gfw) were obtained from the control treatment (no foliar application). In general, the results showed that foliar application of amino acids as a biological stimulant had a positive effect on improving the quality characteristics of the Physalis alkekengi L and increased the production of biochemical compounds of the plant. Manuscript profile
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  5 - Phytochemical, antioxidant and antibacterial properties in different concentrations of Physalis alkekengi L. extract
  simin Arian Seyedeh Fatemeh Habib Hosseini
  10.30495/ejmp.2022.1946341.1665
  With the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. The aim of this study was to evaluate the phytochemical, antioxidant, and antibacterial properties of di More

  With the increasing resistance of bacteria to antibiotics and their side effects, the use of medicinal plants in the treatment of bacterial infections is increasing. The aim of this study was to evaluate the phytochemical, antioxidant, and antibacterial properties of different concentrations of methanolic extract of Physalis alkekngi. For this purpose, the calyx and fruit of the P. alkekengi L. were collected from an area near the city of Tonekabon in the summer of 2019 from a height of 120 meters and the antimicrobial activity of the extracts on pathogenic bacteria was determined by disk diffusion methods, MIC, and MBC. Total phenol and flavonoid contents were measured by folin-ciocalteu reagent and aluminum chloride colorimetric method, respectively. In addition, total anthocyanin was measured by spectrophotometry as well as antioxidant activity of extract using DPPH method. Based on the results, the highest total phenol content at a concentration 50 mg-1 ml of calyx extract was 32.92±1.738 mgEGA g-1 DW. Also, the content of flavonoid and anthocyanin compounds in the calyx extract was more than that of the fruit extract. Based on the results of antioxidant activity also showed  that the highest DPPH radical inhibitory effect were obtained at concentrations of 100 and 150 mg/ml of calyx extract 51.43% and 51.58%, respectively. In addition, calyx and fruit extracts showed significant inhibitory activity against the studied bacteria as the highest inhibitory effect on Staphylococcus aureus was obtained at a concentration of 1000 mg -1ml of calyx and fruit extracts. The results of this study indicated that the calyx and fruit extracts of P. alkekengi are rich in antioxidant compounds, especially phenolic compounds, and the antimicrobial activity of the extracts showed a significant positive correlation with total phenol content. Therefore, the antimicrobial properties of the calyx and fruit extracts may be attributed to their phenolic compounds and these extracts can be recommended for medicinal applications. Manuscript profile
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  6 - Effect of foliar application of urea and salicylic acid on morphological traits and phytochemical compounds of Physalis alkekengi L.
  Ali Pezeshki Hassan Nourafcan Mehdi Oraei Naser Mohebalipour Asad Asadi
  10.30495/ejmp.2022.1944263.1662
  Physalis alkekengi L. belongs to the Solanacae family and its fruit is widely used in traditional medicine to treat diseases such as kidney and urinary tract stones, gout and hepatitis. Since the use of biostimulants in agriculture can be effective in improving the quan More

  Physalis alkekengi L. belongs to the Solanacae family and its fruit is widely used in traditional medicine to treat diseases such as kidney and urinary tract stones, gout and hepatitis. Since the use of biostimulants in agriculture can be effective in improving the quantity and quality of active ingredients of medicinal plants and improving their yield, in this study, to evaluate the effect of salicylic acid and urea foliar application on morphological characteristics and phytochemical composition of this plant an experiment in a completely randomized design in research greenhouse of Islamic Azad University, Miyaneh Branch in 2019 was conducted. Spraying salicylic acid (0.001, 0.0025, 0.005 and 0.01 mM) and urea (0.25, 0.5, 1 and 2%) was applied in three stages with an interval of 10 days in three repetitions. Extraction was performed simultaneously with harvest (mid-September) by soaking method and the amount of phytochemical compounds in the shoot was determined using HPLC. Based on the results of variance analysis, the effect of foliar application on all morphological traits of shoots (except leaf width), root morphological traits and yield traits was significant. Increasing the concentration of urea and salicylic acid in most of the measured traits showed a positive effect. The highest increase in the mentioned traits was mainly related to the concentrations of 1% and 2% urea and salicylic acid 0.01 mM. Compared to the control, concentrations of 1% urea and 0.01 mM salicylic acid increased the number of fruits (76.8% and 64.6%, respectively), fruit diameter (17.3% and 25.7%, respectively), fruit length (15.07 and 33.4%, respectively), fresh weight of shoots (29.9 and 56.4%, respectively) and dry weight of shoots (28.4 and 61.4%, respectively). In addition, with increasing salicylic acid concentration the amount of luteolin, quercetin, campferol, ferulic acid and chlorogenic acid increased compared to the control treatment. Manuscript profile
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  7 - Effect of hydroalcoholic extract of Physalis alkekengi (on the growth of a tumor of breast cancer associated with positive steroid receptor in mice)
  maryam teimouri
  A large number of clinical and pre-clinical studies have extensively shown the therapeutic effects of the hydroalcoholic extract of the physalis alkekengi on several diseases, but so far there is not much information about the healing properties of the hydroalcoholic ex More

  A large number of clinical and pre-clinical studies have extensively shown the therapeutic effects of the hydroalcoholic extract of the physalis alkekengi on several diseases, but so far there is not much information about the healing properties of the hydroalcoholic extract of this plant on breast cancer. This study investigated the therapeutic effects of Physalis alkekengi hydroalcoholic extract on steroid receptor-dependent breast cancer on mouse model, and the results of this study showed that extracts of Physalis alkekeng, especially in two concentrations (100mg / kg, 50), have inhibitory effects on cancer tumor growth The chest was in the treated group, as well as changes in the tissue of the anus The biology in breast tumors of the groups treated with P.alkekengi extract was observed in comparison with the control group. The findings showed that the extract of the medicinal plant of the puppet had effective effects on the treatment of steroid receptor-dependent breast cancer in Balb/c mice. Manuscript profile
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  8 - Inhibitory effects of Behind the scenes medicine extract (Physalis alkekengi) on prostate cancer caused by DMBA injection in mice
  Maryam Teimouri fariba khosravinejad
  10.30495/jdb.2021.683731
  Introduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extra More

  Introduction: Although many clinical and pre-clinical studies have widely demonstrated the therapeutic effects of hydroalcoholic extract of the puppet pup on several diseases, there is little information on the therapeutic properties of this plant's hydroalcoholic extract on prostate cancer. In this study, we evaluated the therapeutic effects of hydroalcoholic extract of Physalis alkekengi extract on prostate cancer induced by injection of 12.7-dimethylbenzanthracene (DMBA) (a carcinogenic drug) on mouse modelMaterials and Methods: After induction of anesthesia, DMBA was injected directly into the prostate gland of male rats and after 14 days, rats received different amounts of puppet extract every 48 hours and by the end of day 21, intraperitoneal injection of puppet extract. In the control group, intraperitoneal injection of normal saline was performed.Results: The results showed that the puppet extract significantly reduced prostate weight, especially at two concentrations (100 mg, 500, and 1000). Histopathological changes were also observed in the prostate tumors of p.alkekengi extract treated groups compared to the control group.Conclusion: It is suspected that the hydroalcoholic extract of the p.alkekengi inhibits abnormal growth, precancerous lesions, and DMBA-induced carcinoma in the BALB / c mouse prostate. Manuscript profile
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  9 - Effects of (Physalis alkekengi) fruit’s alcoholic extract on development of placentas in pregnant wistar rats
  مهناز نسیمی میترا حیدری نصرآبادی عبدالحسین شیروی
  In the present study, the teratogenic effects of Physalis alkekengi on the development of placentas at 4th and 6th days of pregnancy had been studied. Material and Methods: Thirty female rats as random divided to 6 groups including control, experimental 1 and experi More

  In the present study, the teratogenic effects of Physalis alkekengi on the development of placentas at 4th and 6th days of pregnancy had been studied. Material and Methods: Thirty female rats as random divided to 6 groups including control, experimental 1 and experimental 2 groups that each one at the 4th and 6th day of pregnancy received doses 8g/kg body weight and 10g/kg body weight and experimental 3 group that at 6th day pregnancy received dose 12g/kg of Physalis alkekengi fruitandrsquo;s alcoholic extract. All placentas removed from uterus at the 15th day of pregnancy to study according to morphologic and histologic. The present data showed that Physalis alkekengi fruitandrsquo;s alcoholic extract injection intraperitoneal at the 4th and 6th days of pregnant rat caused significant reduction of placentas diameter and weight and volume in experimental groups in comparison with control group and reduction of diameter and weight and volume in experimental 2 group in comparison with control group. Also morphologic studies showed that had been blood corona at the percent out of placentas experimental groups in comparison with control group. In addition tissue Studies showed the significant increase of the hofbauer cells number at placentas experimental groups in comparison with control.Physalis alkekengifruitandrsquo;s alcoholic extract through suppression of cell division and differentiation and function reduction of some of enzymes and hormones, probably can have negative effects on placentas deficiency development and cell differentiation of some cells. According to reported physiological effects of physalins such as physalin F, alcoholic extract teratogenic effects might be related to physalin F. But it is essential to have more quantitative and qualitative researches in order to have conclusive result. Thus it is recommended to pregnant womenfolk than up to researches completion about this medicinal plant have not used this plant in pregnancy period. Manuscript profile