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  1 - The effect of a session of intense resistance activity with glutamine supplementation on the relative expression of myogenin and myosin creatine kinase genes in the fast-twitch muscle fibers of adult male Wistar rats.
  mansoor mottahedi Tahereh Bagherpoor َArdeshir Zafari nematallah nemati
  Background & Aim: Despite the importance of resistance protocol and glutamine on hypertrophy, their effect on myogenic genes expression process is still unknown. Therefore, the aim of the present study was to investigate the effect of an intense resistance session w More

  Background & Aim: Despite the importance of resistance protocol and glutamine on hypertrophy, their effect on myogenic genes expression process is still unknown. Therefore, the aim of the present study was to investigate the effect of an intense resistance session with glutamine on Myogenin and Myosin creatine kinase gene expression in male Wistar rats. Materials & Methods: 30 8-week-old male rats with an approximate weight of 220±20 were prepared and divided into three groups, control, intense resistance training, and intense resistance training with glutamine, in a simple random manner. The training groups participated in a resistance session of climbing the ramp with 4 sets, 5 repetitions, 30 seconds of rest between repetitions and 2 minutes of rest between sets. Glutamine was once a day powder dissolved in 100 cc of distilled water at a dose of 5.5 grams per kilogram of body weight every day for 5 days. The Extensor Digitorum long muscle tissue was sent to the relevant laboratory to study the expression of Myogenin and Myosin creatine kinase genes. The relative fold change method was used to check gene expression data at a significance level of 5%. Results: The gene expression results showed that myogenin and myosin creatine kinase gene expression levels increased significantly as a result of a high-intensity resistance training session with glutamine compared to the control group, and this value was more pronounced in the resistance training group (p<0.05). Conclusion: It seems that an intense resistance training session is more effective than glutamine on the increase of myogenic genes. Manuscript profile