List of Articles hCG

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  1 - Effect of injection of GnRH and hCG on day 5 post mating on maternal P4 concentration and reproductive performance in Afshari ewes
  Mehri, R., Rostami, B., Masoumi, R., Shahir, M.H. .
  Embryonic mortality is a common cause of economic loss in sheep. Insufficient luteal function and low concentration of maternal progesterone is one of the major reasons of this mortality. This study was conducted to investigate the effects of GnRH and hCG administration More

  Embryonic mortality is a common cause of economic loss in sheep. Insufficient luteal function and low concentration of maternal progesterone is one of the major reasons of this mortality. This study was conducted to investigate the effects of GnRH and hCG administration on day 5 after mating on reproductive performance in ewes. Total of 60 synchronized ewes were mated with fertile rams and equally were assigned to four groups. Ewes in GnRH, hCG and hCG+GnRH groups (n=15/group) received an i.m. injection of 25 μg GnRH analogue, 400 IU hCG and 25 μg GnRH analogue + 400 IU hCG on day 5 post-mating, respectively. The ewes in the control group (n=15) did not receive any treatment. Blood samples were collected on days 7, 12, 17 and 22 post-mating. Plasma P4 concentrations were higher at days 12 and 17 and 22 postmating in GnRH, hCG and hCG+GnRH treated ewes than those of control ewes (P < 0.05). There was no difference in lambing rate and litter size of ewes as well as in birth weight of lambs in different groups. Weaning weight of single lambs in hCG+GnRH group (34.08 ± 0.12 Kg) was greater than that of other groups. In conclusion, the results of this study demonstrated the efficiency of GnRH and hCG administration on day 5 after breeding to increase the maternal P4 concentrations. However, there was no significant effect of such hormonal treatments on reproductive efficiency of Afshari ewes. Manuscript profile
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  2 - Effects of human chorionic gonadotropin on spermatogonial stem cell colony formation and differentiation after in vitro Coculture with Sertoli cells
  Narenji Sani, R., Tajik, P., Damghanaian, N., Javdani, G. .
  Spermatogenesis is a complex developmental process that originates from spermatogonia stem cell. This process consists of sequential, highly organized steps of cell proliferation and differentiation resulting in the generation of functional spermatozoa. Therefore, the a More

  Spermatogenesis is a complex developmental process that originates from spermatogonia stem cell. This process consists of sequential, highly organized steps of cell proliferation and differentiation resulting in the generation of functional spermatozoa. Therefore, the aim of the present study was to determine the effects of human chorionic gonadotropin (hCG) on spermatogonial stem cell colony formation and differentiation after in vitro Coculture with Sertoli cells. In this experimental study, Sertoli and spermatogonial cells were isolated from 3- to 5-month-old calves. Co-cultured Sertoli and spermatogonial cells were treated with hCG in treatment groups before colony assay with 2, 5 and 10 IU/ml culture medium. Vimentin and oct-4 immunohistochemical staining were used for Sertoli and spermatogonial stem cell colony detection, respectively. The present study showed that hCG increase both colony diameter and colony number. hCG can induce both proliferative pathway and differentiation process in SSCs Coculture with Sertoli cells. Manuscript profile
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  3 - Efficacy of CIDR or FGA Sponges with hCG Treatments on the Conception Rate and Prolificacyin Lori Ewes Out of the Breeding Season
  M.M. Moeini F. Alipour M.R. Sanjabi
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  4 - The effect of human gonadotropin and cinnamon hydroalcoholic extract on testes and seminal vesicles in adult male rats
  elnaz shikhzade mamoii akbar karimi Ali Asghar Pileh Varian
  10.30495/jdb.2021.683733
  Background and Aim: Since HCG stimulates the production of testosterone and increases androgen production, it is used in the treatment of infertility and in some cases, inflammatory conditions reduce its effect. In this study, due to the known anti-inflammatory effect o More

  Background and Aim: Since HCG stimulates the production of testosterone and increases androgen production, it is used in the treatment of infertility and in some cases, inflammatory conditions reduce its effect. In this study, due to the known anti-inflammatory effect of cinnamon, it was used as a supplement to influence the effect of HCG on sexual activity of Adult male rats.Materials and Methods: In this experimental study, 24 Adult male Wistar rats were randomly divided into 4 groups of 6 including control group (daily subcutaneous saline), one HCG treatment group (50 IU / ml daily). Subcutaneous), treatment group with two hydroalcoholic extracts of cinnamon (30 mg / kg daily intraperitoneally) and treatment group with three HCG and hydroalcoholic extract of cinnamon (50 IU / ml daily subcutaneous injection and 30 mg / kg intravenous injection daily). Peritoneal) were divided. The rats were treated for 7 days, anesthetized after 14 days and after hematoxylin-eosin staining testes and seminal vesicles were examined by light microscopy. Data were analyzed using one-way ANOVA.Results: The results of the present study showed that the mean testicular and seminal vesicle weight, seminal vesicle diameter and seminal vesicle thickness and reproductive membrane thickness were significantly higher in the HCG and cinnamon receiving group (P <0.001). ).Discussion & Conclusion: Based on the results of this study, the combination of hydroalcoholic extract of cinnamon and HCG could lead to better development and testicular and seminal vesicle function in Adult male rats Manuscript profile
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  5 - اثر ترکیبی دو هورمون گنادورلین و پروستاگلندین(PGF2α) بر تکثیر نیمه مصنوعی ماهی حوض(Carassius auratus)
  مهدی پارسیانی مازیار یحیوی میر مسعود سجادی عسکر کریم آبادی حسن محمد زاده
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  6 - The Effect of HCG and Zingiber Extract on the Growth of Gonads and Accessory Glands in the Immature Male Rats
  Mozhgan Bagherian Akbar Karimi Ali Asghar Pilevarian
  The human chorionic gonadotropin (HCG) hormone is used for infertility treatment. The existence of some inflammatory factors reduces the therapeutic effect of HCG. Therefore, a complementary factor is needed to improve HCG performance. Zingiber is the oldest herbal medi More

  The human chorionic gonadotropin (HCG) hormone is used for infertility treatment. The existence of some inflammatory factors reduces the therapeutic effect of HCG. Therefore, a complementary factor is needed to improve HCG performance. Zingiber is the oldest herbal medicines with antiinfammatory property. Thus the aim of this study was to investigate the effect of HCG and Zingiber extract on the gonads and accessory glands in the immature male rats. A total of 24 immature male Wistar rats were divided into four groups and treated with physiology serum (control), HCG hormone (experimental 1), zingiber extract (experimental 2), and HCG combined with Zingiber extract (experimental 3). After treatment, rats were autopsied. The testis and seminal vesicle were weighed. After tissue slide preparation, types A and B spermatogonia cells and primary spermatocytes were counted and the diameter of the seminiferous tubules and the thickness of the germinal layer were measured. The obtained results were analyzed using one-way analysis of variance (ANOVA) in SPSS software. The research results showed that the testicle weight in the experimental group 1 (HCG) and experimental group 3 (HCG and extract) has increased in comparison with the control group, but there is no significant difference. The weight of the seminal vesicle, number of types A and B spermatogonia cells, number of primary spermatocytes, diameter of seminiferous tubules, and thickness of the germinal layer have significantly increased in the experimental group 1 and experimental group 3 compared to control. HCG combined with Zingiber extract can positively affect the growth of gonads and accessory glands and development of spermatogenesis. Manuscript profile
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  7 - A study on the possible effects of administration of human chorionic gonadotrophin, at 5th day after AI, to improve conception rate and serum progesterone concentration in Holstein dairy cattle
  , O Ataie بهرام Salasel, A. Mehrabi
  The objectives of this study were to determine the effect of administration of exogenous hCG 5 days after artifcialinsemination (AI) on serum progesterone concentration and conception rate in dairy cows.39 lactating dairy cattlerandomly allotted to 2 experimental groups More

  The objectives of this study were to determine the effect of administration of exogenous hCG 5 days after artifcialinsemination (AI) on serum progesterone concentration and conception rate in dairy cows.39 lactating dairy cattlerandomly allotted to 2 experimental groups: Treated group included 19 dairy cows that received 3000IU hCG on day5 after AI and non treated (control) group included 21 dairy cows that only received 5ml normal saline 5 day after AI.Blood sampling obtained on day 5, before administration of exogenous hCG and normal saline, and also on day 13after AI to measure serum progesterone concentrations. Pregnancy diagnosis was performed by rectal palpation 40-60 days after AI. On day 13 average serum progesterone concentrations were 7.72ng/ml and 8.25ng/ml in hCG andcontrol groups respectively. Pregnancy proportion in hCG and control groups were 31.6% and 47.6% respectively.Statistical analysis of results did not show any signifcant difference between two groups in respect to pregnancyproportion or progesterone concentrations (p>0.05). Manuscript profile
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  8 - Induction of estrus in anestrous Terrier by a combination of cabergoline and HCG
  A. Rastegarnia, M. Fatehfar ارسلان Amirfallah , N. Moradi
  In this experiment, the effect of oral administration of cabergoline, an anti-prolactin drug on induction of fertileestrus in bitches was investigated. For this purpose, fourteen bitches from terrier breeds were used in the studyat their already determined periods of an More

  In this experiment, the effect of oral administration of cabergoline, an anti-prolactin drug on induction of fertileestrus in bitches was investigated. For this purpose, fourteen bitches from terrier breeds were used in the studyat their already determined periods of anestrous. Four dogs formed the control group, while 10 bitches weretreatment group. All treatment females were administered with recommended doses (5µg/day) of cabergolineformulation marketed for use in women. An aqueous solution of cabergoline (casber, Pharmacia, Italy) was orallyadministered until 2 days after the onset of proestrus or for a maximum of 41 days. The dogs with signs of proestrus(8/10) following the treatment were assigned into two subgroups. Five hundred IU of HCG was intramuscularlyadministered to four of these dogs on days 1 and 3 of estrus. The remaining 4 dogs were not treated with HCG.Blood samples were taken once from all females during the frst days of treatment and then every other dayduring the beginning the behavioral estrus to measure progesterone concentrations. Induced estrus rates and meantreatment and proestrus durations of dogs in treatment were compared. In the treatment proestrus was inducedbetween days 21– 41 (mean: 29±6.5 days), in the ratio of 80.0 (p < 0.05). The duration of proestrus and oestruswas found to be 8.1 ±1.9 (range, 6 to 11).The duration of estrus in the HCG (+) and HCG (-) subgroups were found to be 10.1 ±1.8 (range9 to 11) and 14 ±2.5 (range, 8 to 12) days, respectively. The conception rate in relation to the number of bitches responding to theestrus induction treatment was similar, 50% (2 out of 4) and mean number of offspring in the HCG(+) and HCG(-)subgroups were found to be 3.5 ± 0.6 and 4 ± 1.4 , respectively (p > 0.05). In control group, all the animals did notshow estrus behavior or pregnancy at the same period.It has been concluded from this study that normal and fertile estrus can be induced more economically in bitchesduring different stages of anestrous using cabergoline formulation marketed for use in women, and HCG injectionson days 1 and 3 of the estrus induced by this method had no positive effects on the pregnancy rates. Manuscript profile