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      • Open Access Article

        1 - Study of cardiovascular biomarkers, cystatin-C and adenosine deaminase in alloxan-induced diabetes mellitus in the dog
        کاوه Azimzadeh
        Diabetes mellitus (DM) is a metabolic disease which may lead to considerable damages in most tissues. The purpose of this study was to assess whether the levels of serum Cardiac troponin I (cTnI), Homocysteine (Hcy), Cystatin c (Cys-C) and adenosine deaminase (ADA) acti More
        Diabetes mellitus (DM) is a metabolic disease which may lead to considerable damages in most tissues. The purpose of this study was to assess whether the levels of serum Cardiac troponin I (cTnI), Homocysteine (Hcy), Cystatin c (Cys-C) and adenosine deaminase (ADA) activity are altered in alloxan induced diabetes mellitus in the dog. In this study, DM was induced by alloxan in the treatment group and three months later, plasma cTnI, Hcy and Cys-C were evaluated by Elisa technique and ADA activity was assessed by Electrochemilumminescence (ECL) method. The results showed significant increases (p<0.01) in cTnI and Cys-C along with a considerable decrease in ADA in the treatment group in comparison to the intact healthy group. Conclusively, increased plasma levels of cTnI and Cys-C in dogs with DM indicates heart and kidney damage respectively, which requires effective measures in the management of diabetes mellitus in dogs. Furthermore, reduction of ADA activity can be attributed to the decline of immune system (especially T cells), high levels of adenosine concentrations for facilitation of glucose transport and/or zinc ion decrease. Manuscript profile
      • Open Access Article

        2 - Caffeine effect on adenosine deaminase catalysis: A new look at the effect of caffeine on adenosine deaminase activity
        Roya Mahinpour Majid Ghasemi Zahra Moosavi-Nejad Zohreh Zahraie
      • Open Access Article

        3 - Investigating the diagnostic value of plasma concentration of adenosine deaminase, sphingosine-1-phosphate and visfatin in the clinical diagnosis of sarcocystosis in small ruminants of Urmia city.
        amir mehmanpasand sohrab rasouli mohamad hosien sadeghi faezeh haidarbeigi soha rezazadeh
        Background and purpose: Sarcocystis is an obligate intracellular parasitic protozoan that can cause digestive disorders in patients. It also causes huge financial losses in the livestock industry. Studying the prevalence of this parasite in livestock can lead to increas More
        Background and purpose: Sarcocystis is an obligate intracellular parasitic protozoan that can cause digestive disorders in patients. It also causes huge financial losses in the livestock industry. Studying the prevalence of this parasite in livestock can lead to increased awareness and the possibility of timely prevention in preventing livestock losses. The present study was conducted to study the changes in the biochemical parameters of adenosine deaminase, visfatin, and sphingosine-1-phosphate due to sarcocyst infection in sheep and goats.Materials and methods: During a period of 6 months (from January 2018 to June 2019), blood was drawn from 160 samples (80 sheep carcasses and 80 goat carcasses) that were examined macroscopically and microscopically. The sample size was determined by assuming the average possible prevalence of contamination to be around 90% and a confidence interval of 95%. The carcasses were observed and examined for the presence of rice grain cysts, and after separating the plasma samples, the parameters of adenosine deaminase, visfatin, and sphingosine-1-phosphate were evaluated.Results: Based on the results of this study, all the mentioned parameters in the study patient's goats and sheep had a statistically significant increase compared to the control group (P<0.05).Discussion and conclusion: In general, sarcocysts can cause changes in the plasma levels of adenosine deaminase, visfatin, and sphingosine-1-phosphate. Therefore, it can be used in the biochemical diagnosis (biomarker) of sarcocyst in ruminants with wider studies of the aforementioned parameters along with other plasma parameters. Manuscript profile
      • Open Access Article

        4 - Alterations of Serum Adenosine deaminase, Total Sialic acid, Malondialdehyde and Heat Shock Protein-27 in Sheep with Naturally Infected Liver Cysticercus taeniaculis
        Kaveh Azimzadeh hooman azizizadeh
        The present study is involved investigation of total sialic acid (TSA), adenosine deaminase (ADA), malondialdehyde (MDA) and heat shock protein-27 (HSP-27) alterations in sheep during Cysticercus taeniaculis infection. For this purpose, 40 parasitized and 40 healthy she More
        The present study is involved investigation of total sialic acid (TSA), adenosine deaminase (ADA), malondialdehyde (MDA) and heat shock protein-27 (HSP-27) alterations in sheep during Cysticercus taeniaculis infection. For this purpose, 40 parasitized and 40 healthy sheep were selected based on observation of cystic form in liver and lack of blood parasite along with no cystic conformation in carcass respectively. Thereupon, ten milliliters of blood were collected via the jugular vein from all ones and transferred to EDTA-contained and non-EDTA tubes and after preparation of plasma and sera, all parameters were detected in groups. The results revealed a significant decrease (p Manuscript profile