• List of Articles Wounds

      • Open Access Article

        1 - Comparative study on geometric and histopathologic effects of polar, semi polar and non-polar fractions Artemisia absinthium extract in rat
        Rezaei, A., Mohajeri, D., Ahmadizadeh, Ch., Jalilzadeh, M. .
        Recovery of Scars is a treatment challenge in some diseases and chronic disorders. For this reason, new compounds are used for rapid recovery of Scars and conglutination. It is expected that Artemisia absinthium as a galenical and herbal drug, has rapid recovery effects More
        Recovery of Scars is a treatment challenge in some diseases and chronic disorders. For this reason, new compounds are used for rapid recovery of Scars and conglutination. It is expected that Artemisia absinthium as a galenical and herbal drug, has rapid recovery effects in scars and sores because has anti- inflammation effects, activation of fibroblast cells and also antihyaluronidase effects cause the rapid recovery of sores. In this study, effects of Artemisia absinthium on recovery of sores as polar, semi polar and non-polar extractions of it are investigated on the rat as a second recovery. After anesthesia, with use of biopsy punch, Created circular sores with full thickness on the 70 female rats and recovery process were investigated in 5 groups. Drug administration and sores measures performed with analyzing of digital Scans, once a day for 21 days. For microscopic observations, gathered Samplings form this tissue in the 0, 3, 7, 14, 21 days, and microscopic symbols are ranged as edema factors and swelling reactions, hyperemia and bleeding, fibroblast, of Coverage tissue, torsion of sores and maturation of granular tissue. After histopathology and Calculation of recovery of sores scale for each drug, the finding results analyzed with SPSS software 17 versions. On the basis of geometric findings of recovery period, observed that semi polar extract of Artemisia absinthium has maximum Contraction of sores and control group has the least contraction of sores. Also, based on the histopathology results, total recovery in this group is better than other groups. In the second and third week. Recovered tissue has better organization than the other groups.  Manuscript profile
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        2 - Study of effect of olive oil on re-epithelialization of epithelial tissue in excision wound healing model in rats
        Abooei Mehrizi, M., Eidi A., Mortazavi, P. .
        Olive oil has been used for medical purposes. It has beneficial effects on cardiovascular and metabolic diseases, inflammatory and autoimmune diseases. The objective of this study was to find out the efficacy of topical administration of olive oil on dermal wound healin More
        Olive oil has been used for medical purposes. It has beneficial effects on cardiovascular and metabolic diseases, inflammatory and autoimmune diseases. The objective of this study was to find out the efficacy of topical administration of olive oil on dermal wound healing in rats. After creating full-thickness skin wounds on the back of 60 male Wistar rats, rats randomly divided into six groups, as control, sham, treatment and standard. Control group was intact. Sham group received eucerin as vehicle. Treated group received the olive oil at doses 2, 5 and 10%, dissolved in eucerin. Standard group were treated with phenytoin ointment 1%. Wound healing rats were calculated on days 3, 7, 11, 14, 18 and 21 post-wounding and the wound tissues were harvested at 3, 7, 14 and 21 days for histological studies. All of rats were sacrificed, and the skin around incision area was dissected and stained by Masson’s trichrome methods for tissue analysis. The results indicated a significant decrease in the diameter of wound in the treated and standard groups comparing to the control groups. A significant increase in the rate of re-epithelialization was observed at 14 days in the treated and standard groups compared to the control group. The results demonstrate that olive oil significantly accelerates cutaneous wound healing and its effect may be due to the increased re-epithelialization. It was concluded that it can be considered as a therapeutic agent for wound healing Manuscript profile
      • Open Access Article

        3 - Resistance Echo in "Bahrain's Wounds" by Ibn Al Bahrain
        Farouq Nemati
        Islamic awareness in the region demonstrates consciousness and emotions to nations' freedom and their readiness to combat injustice and impression undoubtedly. The present paper attempts to extract the resistance themes in   "Bahrain's Wounds" by Bahraini poet More
        Islamic awareness in the region demonstrates consciousness and emotions to nations' freedom and their readiness to combat injustice and impression undoubtedly. The present paper attempts to extract the resistance themes in   "Bahrain's Wounds" by Bahraini poet Ibn Al Bahrain by analytical – descriptive method.  The outcomes express that suffocation and dictatorship in Bahrain are the most important factors to form the resistance concepts in his poetry. He also applied various methods such as mocking House of Khalifa, enjoying the rhetorical and oratorical patterns to stay in patience condition. The abovementioned poet also remarks and points out Islamic Republic of Iran's revolution and knows it as a blessed event which ended injustice and chaos in the world. Manuscript profile
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        4 - cash of Ode “Andalusian wounds of Iraq” Based on Lacla and Mouffe Approach
        پرویز احمدزاده هوچ Ali Sayadani Abdolahad Gheibi Atefeh Rahmani
        Critical Discourse Analysis (CDA) plays an important part in finding insights into a discourse. CDA runs a contentious examination of texts and plays a significant part in expression of textual implications and connotations. It helps going over the formalistic gloss of More
        Critical Discourse Analysis (CDA) plays an important part in finding insights into a discourse. CDA runs a contentious examination of texts and plays a significant part in expression of textual implications and connotations. It helps going over the formalistic gloss of the text which poses barriers to capturing its true sense. It helps discover underlying discourse and latent layers of meanings. CDA differs from discourse analysis in terms of its methodology of examination. It is not pure examination of text or discourse within the textual framework. Boshra albostani, a renowned contemporary Iraqi poetess with a prominent poetic status. The distinctive linguistic structures of her poems have captured the attention of researchers. Employing Laclau and Mouffe approach, this research attempts to examine Al Bostani’s Ode of “Andalusian wounds of Iraq”. As one of her notable works, this ode signals a civilizational attitude as it was composed during years of Iraq’s occupation. The theme of resistance is the centralsignifier of this work while betrayal and handing the keys to the country to outsiders form other signifiers around which other secondary signifiers are articulated. Chain of Equivalence takes shape to breaks the discourse of others. In an ideological foray, it attempts to unveil the actual, consistence identity of the other party. Here, the poet relies on an inspiring, dynamic poetic language to enchantingly portray the exposition of the actual identity of the other party. Manuscript profile
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        5 - A Review of the Therapeutic Effects of Chamomile(Matricaria Chamomile) in Traditional and Modern Medicine
        sepideh dolati
        Introduction: Research and study on the therapeutic effects of plants as well as on people's acceptance of these plants has been considered. Chamomile (Matricaria Chamomile) is one of the most widely used plants in traditional medicine. Chamomile is one of the medicinal More
        Introduction: Research and study on the therapeutic effects of plants as well as on people's acceptance of these plants has been considered. Chamomile (Matricaria Chamomile) is one of the most widely used plants in traditional medicine. Chamomile is one of the medicinal plants for which various effects have been mentioned in traditional and modern medicine. In this article, studies on the therapeutic effects of Chamomile have been reviewed. Materials and methods: In this study, valid scientific articles, since 2000, on the pharmacological effects of Chamomile in Pubmed, ISI Web, Scopus, Google Scholar, SID and Magiran databaseshave been used, and Persian and English studies were intended in the search. Findings: In clinical and experimental studies, the therapeutic effects of this plant on the diseases of the gastrointestinal tract, neuropsychiatry, menstrual problems, anti-inflammatory, antiviral, antimicrobial, antioxidant, antispasmodic, analgesic and anticancer properties and wound healing have been proven. Conclusion: Matricaria Chamomile is recognized worldwide as an important medicinal plant. The various uses of this plant in the treatment of diseases from ancient times and its use in the pharmaceutical industry are the reason for its noticeable worthiness and valuable benefits in the world. Manuscript profile
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        6 - بررسی خاصیت ضد میکروبی عصاره تام و سه فراکشن Platychaeteaucheri (Boiss.) Boiss علیه 5 سویه استاندارد میکروبی و سویه های بالینی اشریشیاکلی
        تینا ذبیحی نیک مژده حاکمی-والا فاطمه باقری بجستانی
        مقدمه و هدف:Platychaeteaucheri (Boiss.) Boiss  متعلق به خانوادهAsteraceae  بوده و یکی از گیاهان بومی ایران است. هدف از این مطالعه، بررسی خاصیت ضد میکروبی عصاره تام متانولی و سه فراکسیون حاصل از بخش هوایی گلدار Platychaete aicheri بر روی تعدادی باکتری گرم مثبت More
        مقدمه و هدف:Platychaeteaucheri (Boiss.) Boiss  متعلق به خانوادهAsteraceae  بوده و یکی از گیاهان بومی ایران است. هدف از این مطالعه، بررسی خاصیت ضد میکروبی عصاره تام متانولی و سه فراکسیون حاصل از بخش هوایی گلدار Platychaete aicheri بر روی تعدادی باکتری گرم مثبت و گرم منفی استاندارد، مخمر کاندیدا آلبیکنس و همچنین نمونه‌های بالینی اشریشیاکلی جدا شده از عفونت ادراری و زخم سوختگی است.         روش تحقیق: عصاره تام متانولی Platychaeteaucheri با روش خیساندن تهیه شد. سپس فراکسیون‌های کلروفرمی، اتردوپترولی و آبی با استفاده از روش استخراج مایع-مایع بدست آمدند. اثر ضد‌میکروبی با روش‌های انتشار در چاهک و براث میکرودایلوشن و بر اساس پروتکل CLSI مورد بررسی قرار گرفت. سویه‌های استاندارد مورد بررسی شامل: اشریشیاکلی (1399 PTCC)، سودوموناس آﺋروژینوزا (1430 PTCC)، استافیلوکوکوس ارﺋوس (1431 PTCC)، باسیلوس سرﺋوس (1247 PTCC) و کاندیدا آلبیکنس (5027 PTCC) بودند. همچنین عصاره و فراکسیون‌ها بر روی سویه‌های اشریشیاکلی‌ بالینی که از نمونه ادرار بیماران بیمارستان امام خمینی تهران که در سال 2013 و زخم‌های سوختگی بیماران بیمارستان شهید مطهری تهران که در سال 2014 جدا شده بودند نیز مورد بررسی قرار گرفتند. نتایج و بحث: عصاره تام و فراکسیون‌های کلروفرمی و اتردوپترولی دارای خاصیت ضدمیکروبی متوسط بر روی سودوموناس آﺋروژینوزا و اشریشیاکلی استاندارد با محدوده MIC (mg/ml 42-35) بودند. دامنه MIC برای ایزوله‌های بالینی اشریشیاکلی در محدوده mg/ml 72-60 بود. فراکسیون آبی فعالیت ضدمیکروبی کمتری نسبت به عصاره تام و سایر فراکسیون‌ها بر روی نمونه‌های استاندارد و بالینی داشت. بر اساس یافته‌ها فراکسیون‌های اتردوپترولی و کلروفرمی اثر آنتی‌باکتریال بیشتری نسبت به عصاره تام متانولی و فراکسیون آبی داشتند. پیشنهاد‌های کاربردی و صنعتی: بر اساس نتایج در صورت عدم سمیّت در مطالعات آتی، این گیاه می‌تواند به عنوان یک منبع آنتی‌باکتریال طبیعی در محصولاتی جهت کمک به درمان عفونت‌های مجرای ادراری و سوختگی مورد استفاده قرار گیرد. Manuscript profile
      • Open Access Article

        7 - گلهای رز ایرانی، یک ضد باکتری طبیعی علیه عامل اصلی عفونت سوختگی پوست، سودوموناس آئروژینوزا
        مائده رزقی سید رضا حسینی دوست ژینوس عسگرپناه
        مقدمه و هدف : رز ایرانی (Rosa foetida) متعلق به تیره گل سرخ می باشد و یکی از گونه های بومی ایرانی به حساب می آید که تاکنون اثرات بیولوژیک گل های آن بررسی نگردیده است. از آنجا که گل های این گیاه در طب سنتی ایران به عنوان مرهم جهت بهبود سوختگی های عفونی پوست به کار می رود More
        مقدمه و هدف : رز ایرانی (Rosa foetida) متعلق به تیره گل سرخ می باشد و یکی از گونه های بومی ایرانی به حساب می آید که تاکنون اثرات بیولوژیک گل های آن بررسی نگردیده است. از آنجا که گل های این گیاه در طب سنتی ایران به عنوان مرهم جهت بهبود سوختگی های عفونی پوست به کار می رود، بر آن شدیم تا برای اولین بار اثر ضد میکروبی عصاره های مختلف گل ها را علیه عامل اصلی عفونت های سوختگی، سودوموناس آئروژینوزا بررسی نماییم. روش تحقیق: بررسی اثر ضد میکروب عصاره ها و تعیین حداقل غلظت مهار رشد باکتری به ترتیب با استفاده از روش چاهک پلیت و روش رقت سازی متوالی در میکروپلیت انجام شد. نتایچ و بحث: تمام عصاره های حاصل از گل ها دارای اثر مهاری بر رشد باکتری بودند که از بین آنها عصاره های آبی و متانولی دارای قوی ترین اثر را نشان دادند. قطر هاله عدم رشد (با غلظت 125 میلی گرم/میلی لیتر) و حداقل غلظت مهار رشد باکتری برای هر دو عصاره فوق نسبتا با اثر داروی استاندارد، ایمیپنم/سیلاستاتین (8/8 میکروگرم/میلی لیتر) یکسان بود. توصیه کاربردی / صنعتی: نتایج مشاهده شده نشان می دهد که گل های رز ایرانی دارای ترکیبات موثره با اثر ضد باکتری علیه سوش های استاندارد و پاتوژن سودوموناس آئروژینوزا جدا شده از پنج بیمار مبتلا به عفونت سوختگی پوست است و کاربرد سنتی این گیاه را در عفونت های سوختگی پوست توجیه می نماید. Manuscript profile
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        8 - Comparative study of Teucrium extract and chlorhexidine in the healing and treatment of experimental oral ulcers
        Pejman Nazem zomorodi loghman Akradi Amir Farhad Kochak Asa’adi
        Background and Aim: The presence of any type of lesion in the mouth, such as injuries, sores or oral pests, in addition to causing pain in the area can cause the animal to not want to receive food as result, reduces weight and production. Teucrium is one of the medicina More
        Background and Aim: The presence of any type of lesion in the mouth, such as injuries, sores or oral pests, in addition to causing pain in the area can cause the animal to not want to receive food as result, reduces weight and production. Teucrium is one of the medicinal plants that have effective healing properties in healing the mucosa. Therefore, the aim of this study was to compare comparative plant extract of Teucrium and chlorhexidine in the healing of experimental oral ulcers. Materials and Methods: In this experimental study, 36 New Zealand male rabbits were randomly divided into 3 equal groups: control without treatment (C), treatment group with 0.2% chlorhexidine (T1) and treatment group with hydroalcoholic extract of Teucrium (T2).  In the beginning after anesthesia, the animals were placed in a supine position on the left side and the mouth of the animals was opened as much as possible by the mouth opener. Then, wound with a diameter of 3 mm was made on the gingival mucosa. Twice a day, the right gingival lesion was impregnated with a swab soaked in chlorhexidine solution (T1 group) and hydroalcoholic extract of Teucrium (T2 group). On days 1, 3, 7, and 14, the gums were sampled and the histopathological criteria for inflammatory cell infiltration, collagen filament arrangement, fibroblast cell presence, vascular formation, and epithelial tissue rearrangement were assessed. Also, the macroscopic diameter of the gingival tissue wound was measured on the mentioned days.Results: In T1 and T2 groups, the criteria for inflammatory cell infiltration, arrangement of collagen and vascular formation and rearrangement of epithelial tissue on days 7 and 14 showed a significant change compared to C group (P < 0.05). In the C group, the criteria of inflammatory cell infiltration increased during the study. In T1 and T2 groups, the macroscopic diameter of gingival tissue ulcer showed a significant decrease compared to C group (P < 0.05).Conclusion: This study showed that Teucrium extract can accelerate experimental wound healing. Manuscript profile