List of Articles Troponin I

• Open Access Article
  • Abstract Page
  • Full-Text
  
  1 - Effects of Long-term administration of sildenafil citrate on serum markers of cardiac injury in the rats
  Zarini, E., Amouoghli Tabrizi, B. *, Fartashvand, M., Sadeghy, R. .
  Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of More

  Nowadays, sexual impotence due to increased heart disease, has led to rising in consumption ofsexual enhancing drugs. In heart failure, due to decreased blood supply to corpus cavernosum,complete erection does not occur, which can lead to sexual dissatisfaction. One of the mostimportant drugs which are used to treat this disorder is sildenafil citrate, a selective inhibitor oftype 5 cGMP. The purpose of this study was to evaluate the long-term side effects of this drugon serum biomarkers of cardiac injury in the rat. In this study, 20 male Wistar rats wererandomly assigned into 2 groups including: control and treatment. In treatment group, sildenafilcitrate use at a dose of 100 mg/kg for 30 consecutive days in oral rout and control group onlyreceived Distilled water. At the end of experiment, the serum levels of cardiac troponin I,creatine kinase- MB, lactate dehydrogenase and aspartate aminotransferase were measured. Theresults obtained showed that sildenafil citrate has protective effects on cardiac enzymes whichmay be in association with releasing of nitric oxide (NO). Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  2 - The Effect of Ethanol Extraction of Aloe vera on Certain Biomarkers of Cardiovascular Disease in Mice Treated with Nanoparticles of Titanium Dioxide
  Fereshteh Javan Masoomi Jila Talat Mehrabad Roghayeh Babri Bonab
  Inroduction & Objective: The effect of ethanol extraction of Aloe vera on certain biomarkers of cardiovascular disease in mice treated with titanium dioxide nanoparticles was studied.Material and Methods: Mice were received titanium dioxide nanoparticles with density of More

  Inroduction & Objective: The effect of ethanol extraction of Aloe vera on certain biomarkers of cardiovascular disease in mice treated with titanium dioxide nanoparticles was studied.Material and Methods: Mice were received titanium dioxide nanoparticles with density of 100 milligrams per kg and ethanol extraction of aloe vera plant with density of 100, 200 and 300 milligrams per kg for 30 days. Plasma levels ofmalondialdehyde, rich sialic acid, troponin I and creatine kinase MB at the end of treatment was evaluated. The antioxidant activity of ethanol extraction in Aloe Vera using free radical DPPH and total phenol levels were considered.Results: The results showed that giving titanium dioxide nanoparticles through the stimulation of oxidative activity had a significant increase in plasma levels of malondialdehyde (MDA). Plasma levels of troponin I, creatine kinase MB and rich sialic acid also significantly increased. With increasing density of aloe vera, the total phenol and antioxidant activity of ethanol extraction increased. Giving the extraction significantly reduced the plasma levels of biomarkers of cardiovascular damage in mice treated with titanium dioxide nanoparticles.Conclusion:According to the results, ethanol extraction of aloe vera as an antioxidant compound is able to reduce the levels of cardiovascular damage in mice treated with titanium dioxide nanoparticles. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  3 - Evaluation of serum homocysteine and cardiac troponin I in sheep with theileriosis in Urmia city
  Kaveh Azimzadeh Asghar Hasanpour
  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep More

  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep affected by theileriosis based on gender and breed in Urmia city. After diagnosis of theileriosis based on clinical and laboratory symptoms, 30 infected sheep were selected (15 Ghezel breed and 15 Makouei breed) with 8 males and 7 females from each breed. Meanwhile, the same number of healthy sheep (based on sex and breed) were selected as healthy group. Thereafter, blood samples were taken from the jugular vein in both groups and the previously mentioned parameters were measured and evaluated statistically. The results showed a significant increase (p≤0.05) in all parameters in diseased sheep in comparison to healthy ones. In terms of gender, significant increase in all parameters were observed in males compared with females and in the case of breed, there was a significant difference between the Makouei breed with healthy sheep and Ghezel with healthy ones (p≤ 0.05). Overall, it can be concluded that increase of serum homocysteine and cardiac troponin I in sheep with theileriosis, especially in males, could be a warning that careful attention should be paid to the prevention and treatment of sheep with theileriosis. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  4 - Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat
  Rasol Sadeghy B. Amouoghli Tabrizi majid fartashvand
  10.30495/jvcp.2021.1922087.1296
  Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, More

  Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine. Since cardiovascular complications related to all three drugs have been reported, the aim of this study was to evaluate the serum levels of cardiac damage index enzymes and tropovinin I following co-administration of sildenafil with dextromethorphan and chlorpheniramine. Forty male Wistar rats were studied in 8 groups, one control group and the rest in the treatment group; Drugs sildenafil citrate (100 mg / kg), dextromethorphan (20 mg / kg), chlorpheniramine (20 mg / kg), dextromethorphan + chlorpheniramine, sildenafil + dextromethorphan, sildenafil + chlorpheniramine, sildenafil + rosemethor + dextrometer , Received food. The results showed that administration of sildenafil to rats did not cause statistically significant changes in serum cardiac injury indices compared with the control group (p < 0.05); The amount of CK-MB also decreased compared to the control group. On the other hand, following administration of chlorpheniramine and dextromethorphan to rats, either alone or in combination, serum levels of AST, LDH and CK-MB increased statistically significantly. Administration of chlorpheniramine caused a significant increase in LDH (p < 0.01) and CK-MB (p < 0.001) compared to the control group and administration of dextromethorphan increased the activity of the studied enzymes which increased AST (p < 0.05). ) And CK-MB (p < 0.001) were significant. Co-administration of sildenafil with dextromethorphan and sildenafil with chlorpheniramine or all three together increased the activity of all three enzymes in the heart damage index. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  5 - Evaluation of cardiac troponin I alterationsin dairy cattle with septicmetritis
  majid fartashvand ali derangian amirali kaveh
  Metritis is an important disease in dairy cattle which causes economical loses including decrease in milk yield, increase calving interval, treatment costs and death of ill cases. Septic metritis usually occurs within 2-10 days after parturition, and characterized clini More

  Metritis is an important disease in dairy cattle which causes economical loses including decrease in milk yield, increase calving interval, treatment costs and death of ill cases. Septic metritis usually occurs within 2-10 days after parturition, and characterized clinically with sever toxemia associated with purulent odorous uterine discharge with or without retained placenta. In this study, serum levels of cTnI were measured in 50 female Holstein cattle with septicmetritis and compared with normal cows. cTnI of serum in disease and control groups were 0.017 ± 0.008 and 0.005 ± 0.000 ng/dl, respectively. Heart rate, respiratory rate and rectal temperature in disease cases were significantly higher than normal cattle. There was significant correlation with cTnI and heart rate and rectal temperature. Endotoxemia is one of possible reasons of elevation of serum cTnI. Cytokines and endotoxins originated from gram negative bacteria that cause myocardium depression and ventricular dilatation. Furthermore impairment of left ventricle function is a significant effect of septic shock.   Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  6 - Investigation of the Level of Serum Troponin I and Comparing it with Serum CK-MB in Diagnosis of Myocardial Infarction
  جمال شمسی پریچهره یغمایی میرحسین سید محمدزاده سید علی حائری روحانی
  The Myocardial infarction (MI) is the fail in reaching blood flow and sufficient oxygen to part of the heart. Te outbreak of MI symptoms might be various and the electrocardiography is not diagnostic in about 50% of the cases that is a potential danger for wrong diagnos More

  The Myocardial infarction (MI) is the fail in reaching blood flow and sufficient oxygen to part of the heart. Te outbreak of MI symptoms might be various and the electrocardiography is not diagnostic in about 50% of the cases that is a potential danger for wrong diagnosis, therefore we need to test the cardiac biomarkers. In this survey the level of Troponin I serum in the diagnosis of the cardiac infarction with CK-MB serum, in 40 MI patients and 40 cardiac patients without MI of Seyyed Al Shohada Heart Hospital in Urmia has been evaluated and compared. the Troponin I through Immunoenzymometric method using AccuBind Kit and CK-MB through DGKC (German Society of Clinical Chemistry) method and IFCC (International Federation of Clinical Chemistry) using Pars Azmun Company kit through photometric method, measurement. and then Conducted  the results' statistical analysis using SPSS 21 software and an independent T-test The results achieved from the comparison between the cTnI and CK-MB of MI patients and patients without MI showed that there was a significant difference between the cTnI of patients without MI and MI patients and also the CK-MB of patients without MI and MI patients at the level of (P) and the cTnI and CK-MB of MI patients is more than patients without MI. therefore their use is necessary for on time diagnosis and treatment of Myocardial infarction. In this survey the cTnI and CK-MB was compared from the viewpoint of sensitivity and specification that regarding the results the cTnI sensitivity and specification with 100% and 97.5% respectively was more than the CK-MB sensitivity and specification with 91% and 75% respectively. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  7 - Investigating the effect of two weeks of Q10 supplementation on troponins I and T in male rats for its inhibitory activity
  Moghgan gudarzi mania roozbayani vahid valipoor dehno Reza Goodarzi
  10.22034/ascij.2023.1984332.1485
  Performing intense exercise activities is associated with an increase in oxidizing substances in the body, which can cause damage to the heart tissue, and subsequently, the level of troponins I and T increases. In such cases, taking nutritional supplements such as coenz More

  Performing intense exercise activities is associated with an increase in oxidizing substances in the body, which can cause damage to the heart tissue, and subsequently, the level of troponins I and T increases. In such cases, taking nutritional supplements such as coenzyme Q10 can probably prevent these injuries. However, no comprehensive studies have been conducted regarding the effects of this food item on the indicators of heart damage following sports activities. For this purpose, 40 8-week-old male Wistar rats with an average weight of 239.48+6.7 grams were randomly divided into 4 groups: placebo, placebo + acute activity, supplement and supplement + acute activity. The supplement groups received 0.02 ml of Q10 supplement per day for two weeks by gavage. The acute activity groups also performed the activity of swimming in water until exhaustion after the completion of the supplemental period. 2 hours after the acute activity, blood samples were taken from the hearts of mice to measure troponin I and T proteins, and then plasma samples were prepared. One-way ANOVA test showed that troponin I and T increased significantly after exercise in both groups compared to before exercise (p=0.000). Also, the results showed that the consumption of Q10 causes a significant decrease in troponin I (p=0.000) and troponin T (p=0.019) compared to the placebo group in response to the inhibitory activity. Based on the results obtained from the present study, two-week supplementation of coenzyme Q10 may be able to reduce the damage caused to the rat's heart due to the activity of the inhibitor. Manuscript profile