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      • Open Access Article

        1 - Evaluation of β-tricalciumphosphate (β-TCP) nanocomposite granules compared with nanocomposite hydroxyapatite (HA) on healing of segmental femur bone defect in rabbits
        Eftekhari, H., Jahandideh, A., Asghari, A., Akbarzadeh, A., Hesaraki, S. .
        The loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. Over the last decades, many efforts have been made to obtain mat More
        The loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. Over the last decades, many efforts have been made to obtain materials that have the potential for high bone regeneration and to replace alternatives to autograft or zenografts. In this study, 45 adult male New Zealand male rabbits weighing 3-5 mg​​/kg, randomly divided into 3 groups of 15, were used. During surgery on the femur of each rabbit, a bilateral, 6 mm diameter defect was created. In the first group (control), no substance was used, in the second group, hydroxyapatite, and in the third group, nanocomposite tri-calcium phosphate (TCP) was used to fill the defect. Bone specimens were harvested for histopathologic evaluation on days 15, 30 and 45 and for evaluation of 4 indexes of union, spongiosa, cortex and bone marrow. The results showed that the results of using nanocomposite tricalcium phosphate in comparison with other groups were significantly different in all cases. Therefore, according to the results, it can be admitted that nanocomposite tri-calcium phosphate scaffold has a positive effect on the healing process and has good bone strength, so it can be widely used in orthopedic surgery as well as tissue engineering. Manuscript profile
      • Open Access Article

        2 - Isolating tricalcium phosphate solubilizing bacteria from wheat and oat soil in Marvdasht
        Fatemeh Naseri Nima Bahador Majid Baser Mehdi Kargar
        Background & Objectives: Many soil microorganisms are ale to solve unavailable phosphorus through metabolic activity and secretion of organic acids. This study was aimed to isolate tricalcium phosphate active solubilizing bacteria from wheat and barley farms in Marv More
        Background & Objectives: Many soil microorganisms are ale to solve unavailable phosphorus through metabolic activity and secretion of organic acids. This study was aimed to isolate tricalcium phosphate active solubilizing bacteria from wheat and barley farms in Marvdasht Plain. Materials & Methods: This cross-sectional study was conducted on 50 barley and 50 wheat farms in Marvdasht Plain. The soil samples were enriched in NRIP media containing 10 percent tricalcium phosphate. The tricalcium phosphate solubilizing bacteria which produced halos on media were determined through biochemical tests, PCR and sequencing techniques. The activity of two active bacteria isolated from wheat and barley farms were analysed by HPLC method in order to investigate the production of secreted organic acids. Results: Overall 9 (18%) and 6 (12%) of the tricalcium phosphate solubilizing bacteria were isolated from the wheat and barley farms located at Marvdasht, respectively. The HPLC analysis showed that the microorganisms isolated from barely and wheats farms produce 4 and 3 respectively, different low molecular weight acids. Conclusion: Since most of the tricalcium phosphate active solubilizing bacteria were isolated from the barely farms, these bacteria can be found in the soils in which less Phosphorus fertilizers were used. Screening of these bacteria in different farms and their identification can be useful in the production of biologic fertilizers and growth of plants in that area. Manuscript profile
      • Open Access Article

        3 - The mechanical performance of silk and collagen nanoparticles for dental applications
        Mohammad Hossein Malekipour Esfahani Behnoush Selahbarzin