List of Articles Tetracycline

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  1 - Application of PLS and PARAFAC in simultaneous spectrophotometric determination of oxytetracycline, tetracycline and doxycycline in honey samples
  Z. Doroudi A. Niazi
  A simple, sensitive, rapid and precise spectrophotometric method has been developed and validated for simultaneous determination oxytetracycline (OTC), tetracycline (TC) and doxycycline (DXC) in honey samples. Chemometrics methods suitable for overlapping spectra and ha More

  A simple, sensitive, rapid and precise spectrophotometric method has been developed and validated for simultaneous determination oxytetracycline (OTC), tetracycline (TC) and doxycycline (DXC) in honey samples. Chemometrics methods suitable for overlapping spectra and have resolved successfully the overlapping bands. Two chemometrics techniques parallel factor analysis (PARAFAC) and partial least square (PLS) were applied to the determination of TCs in their ternary mixture and the proposed calibration techniques were validated by analyzing synthetic mixtures consisting of these drugs. The calibration and validation sets were constructed with solutions in the concentration ranges from              (0.1-16) µgmL-1 for TC, (0.1-30) µgmL-1 and (0.1-20) µgmL-1 for DXC and OTC. The procedure was repeated at different pH values. Partial least squares (PLS) models were built at each pH and used to determinate a set of synthetic mixtures. The best model was obtained at pH =8.0. The PARAFAC model was applied to a three-way array constructed using all the pH data sets and enable better results. The RMSEP for DXC, OTC and TC with PLS and PARAFAC were 0.123, 0.236, 0.167 and 0.0196, 0.0480, 0.0316 respectively. Manuscript profile
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  2 - Evaluation of Molecularly Imprinted Polymer Performance for Removal of Oxytetracycline from Aqueous and milk
  S. Jafari Mohammad Dehghani Elham Ghorashi Navid Nasirizadeh
  Among the growing concerns over recent decades in the field of environmental pollution, is the use of antibiotics increase bacterial resistance to antibiotics used in human body. The aim of this research was to synthesis of Molecularly Imprinted Polymer (MIP) particles More

  Among the growing concerns over recent decades in the field of environmental pollution, is the use of antibiotics increase bacterial resistance to antibiotics used in human body. The aim of this research was to synthesis of Molecularly Imprinted Polymer (MIP) particles for the Oxytetracycline (OTC) antibiotic removal from the aqueous and milk. The influence of different parameters such as pH (2-10), contact time (5-120 min) and MIP amounts (0.1 – 1.0 g/L) was studied on optimization of OTC removal. The synthesized MIP particles was characterized by scanning electron microscopy and absorption and desorption of nitrogen (BET). The results showed that the removal efficiency is higher in neutral pH and with increasing amounts of MIP particle, removal efficiency increases. The best condition for OTC removal was determined at pH, 6.5, 90 min and 280 mg/g as maximum absorption capacity. The MIP performance for OTC removal from milk was investigated too. The performance of MIP polymer particles in OTC removal in milk samples supplied from an animal husbandry in Yazd showed that these adsorbents can help to effectively reduce the residues of drug contaminants in dairy samples. Manuscript profile
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  3 - Determination of oxytetracycline residues in the distributed meat products in Tabriz by high-performance liquid chromatography method
  Jafar Shadjou Mohammad Hosein Movassagh
  10.30495/jfh.2023.1989199.1405
  The excessive use of antibiotics in animal husbandry has led to the appearance of antibiotic residues in meat and could threaten public health. The study aimed to determine the oxytetracycline residue level in meat products in Tabriz. A total of 60 samples of meat produ More

  The excessive use of antibiotics in animal husbandry has led to the appearance of antibiotic residues in meat and could threaten public health. The study aimed to determine the oxytetracycline residue level in meat products in Tabriz. A total of 60 samples of meat products (sausages, Persian sausages and hamburgers, 20 samples from each meat product) were randomly collected from food supply stores in Tabriz from March to May 2021. High-performance liquid chromatography was used to determine the level of oxytetracycline residue levels in the samples. The results showed that the mean of oxytetracycline residue in sausage, Persian sausage, and hamburger was 82.48±7.06, 57.35±4.27, and 150.79±3.65 µg/Kg, respectively. The mean value of oxytetracycline residues showed a significant (p<0.05) difference between the three products. Also, oxytetracycline residue was observed in all samples. However, in all samples, it was below the allowed limit of Codex Alimentarius (200 µg/kg). The average residue of oxytetracycline in hamburgers was significantly higher than in sausages. In hamburgers with 90% meat, the average amount of oxytetracycline was more than in hamburgers with 70% meat, which can be related to the percentage of meat in the product (p<0.05). Although the level of oxytetracycline residue in the present study was less than the permissible limit, considering the consumption of meat products in the country, it is necessary to control and monitor the presence of antibiotics in foods of animal origin. Manuscript profile
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  4 - The effect of oxytetracycline on the amount of calcium and phosphorus of blood and density of bone tissue in broiler chickens
  aziz Norouzi afshin zakeri seyyed esmaeil safavi
  This study was designed to investigate the effects of oxytetracycline on the amount of calcium and phosphorus of blood and bone tissue density in broiler chickens. For this purpose, 72 day-old Ross chicks of, 308 strain in a completely randomized design in two groups: t More

  This study was designed to investigate the effects of oxytetracycline on the amount of calcium and phosphorus of blood and bone tissue density in broiler chickens. For this purpose, 72 day-old Ross chicks of, 308 strain in a completely randomized design in two groups: the control group (without dietary antibiotic) and the treatment group (with a diet containing oxytetracycline 50%, 3 gr per kg of diet) with 6 replicates in the same environmental conditions and management were studied for 42 days. In this experiment, the diameter of femoral shaft and ratio of various tissues of the femur and skull were studied. Blood parameters included calcium and phosphorus. In the group treated with oxytetracycline, femur shaft diameter was significantly decreased with the addition of drug to diet (p<0.01). Also the trabeculaes in the femur shaft and skull significantly decreased (p<0.01). In the group treated with oxytetracycline, the bone marrow of femur and skull significantly increased (p<0.01). The effect of oxytetracycline on cartilage of skull was no significant. The addition of oxytetracycline, to diet had no significant effect on calcium and phosphorus of blood. The results showed that oxytetracycline reduced absorption of calcium and phosphorus from the intestine and reduced bone density. Manuscript profile
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  5 - High tetracycline resistance alarm in Iran
  sahar nouri Mohammad Nodargah
  The bacterial resistance to antibiotics have become a worldwide health concern. Tetracycline has not been excluded, its low price and broad-spectrum antimicrobial agent activity have led to high consumption in the aspects of health care and food hygiene. Escherichia col More

  The bacterial resistance to antibiotics have become a worldwide health concern. Tetracycline has not been excluded, its low price and broad-spectrum antimicrobial agent activity have led to high consumption in the aspects of health care and food hygiene. Escherichia coli is an indicator of bacterial species in food, human, and livestock health, which has led to a good model for studying antibiotic resistance. The purpose of this study was to evaluate the E.coli strains tetracycline resistance status in food, human and animal populations of Iran up to 2018. The discussion about food is important as a common area of human, animal populations and environment and also as one of the resistant strain transmission factors. A survey of the study’s results showed that the average resistance to Tetracycline in poultry with Colibacillosis 86/74 percent, human isolates 64/11 percent and food isolates are 60/9 percent. Regarding this level of resistance, it is recommended that the distribution and consumption of tetracycline in Iran should be discontinue for a period of time in order to reduce the population of resistant strains by other antibiotics and methods. The molecular epidemiology and affecting factors of resistance creation should be evaluate. Manuscript profile
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  6 - Evaluation of Tetracycline Antibiotic Level in Raw Milk using Infrared Fourier Transform Spectrum
  Ali Ghanbari Afshin Akhoondzadeh-Basti
  10.30495/jfm.2022.1925838.1706
  Due to the consumption of milk in the daily diet of humans as one of the main food groups, the health of this product is of particular importance. In this study, FTNIR and FTMID were used to evaluate the amount of tetracycline in raw milk and compared with the reference More

  Due to the consumption of milk in the daily diet of humans as one of the main food groups, the health of this product is of particular importance. In this study, FTNIR and FTMID were used to evaluate the amount of tetracycline in raw milk and compared with the reference HPLC method. Forty milk samples were prepared with different concentrations of tetracycline 0, 50, 100 and 150 ppb. Also, by comparing the control sample with the samples containing tetracycline, the most changes in the near-infrared spectrum occur in the wavelength range of 5200 to 5000 and 7000 to 6800 and the changes of the middle infrared spectrum occur in the wavelength range of 700 to 600, 1700 to 1500 and 3400 to 3200 cm-1. Using these predictions, the amount of tetracycline was predicted by NIR and MIR methods with correlation coefficients of 0.99 and 0.90 and RMSEP error rates of 18.60 and 20.06, respectively. Although the correlation coefficient of both methods is high, but the error rate of the prediction method is high for both methods, especially the MIR method. But the results of the NIR spectrum are closer to the reference method (HPLC) and can replace this method. Due to the lower error rate of NIR and the advantages of this identification method compared to High Performance Liquid Chromatography, this method can be introduced as a suitable alternative to destructive methods of measuring tetracycline in milk. Manuscript profile
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  7 - Evaluation of the effect of lemongrass (Cymbopogon citratus) essence on food infectious microorganisms
  Nazanin Khakipour Fatemeh Haghshenas
  10.30495/jfm.2022.1926703.1707
  The aim of this study was to evaluate the antibacterial properties of lemongrass essence (Cymbopogon citratus) against pathogenic bacteria. For this purpose, the antimicrobial activity of the essence was determined by minimum inhibitory concentration (MIC) and minimum b More

  The aim of this study was to evaluate the antibacterial properties of lemongrass essence (Cymbopogon citratus) against pathogenic bacteria. For this purpose, the antimicrobial activity of the essence was determined by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against five pathogenic bacteria and food contamination factors such as gram- positive bacteria such as Bacillus cereus and Clostridium botulinum and gram- negative bacteria such as Escherichia coli and Pseudomonas aeruginosa and Shigella. The results showed that the highest MIC and MBC were observed against Shigella Gram-negative bacteria (MIC 566.66 ppm, MBC: 658.33). The lowest MIC and MBC values were observed against Clostridium botulinum (MIC 258.33 ppm, MBC: 408.08). Antibacterial activity of different concentrations (100, 250, 500, 750 and 1000 ppm) of the essence was also determined by the diameter of the inhibition zone and compared with the antibiotic tetracycline. The diameter of the growth inhibition zone of different concentrations of Bacillus cereus essence is 10.29- 24.83 mm, Clostridium botulinum is 9.65- 28.72 mm, Escherichia coli is 8.25- 19.58 mm, Pseudomonas aeruginosa 6.41- 18.15 mm and 5.41- 16.41 mm respectively. In total, concentrations of 750 and 1000 ppm had the highest antimicrobial activity compared to antibiotic tetracycline. Based on the results of this study, lemongrass essence has an acceptable antimicrobial effect and can be used as an alternative to common antimicrobial compounds. Manuscript profile
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  8 - P-type semiconducting NiO nanoparticles synthesis and its photocatalytic activity
  Alireza Heidarineko Azar Bagheri Ghomi
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  9 - Rapid Synthesis of Silver Nanoparticles and Their Decoration on TiO2 by Plasma-Over-Liquid Process: Characterization and Application for Tetracycline Antibiotic Degradation
  Margarita Skiba Victoria Vorobyova
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  10 - Determination of oxytetracycline residue in Cyprinus carpio of muscle and liver by HPLC method
  T. Naji H. Hosseinzadeh M. Ghomi B. Bahrami
  Oxytetracycline (OTC) is the only form of tetracycline compounds which is approved by FDA to be used for prevention and treatment of aquatic animals’ diseases. The aim of this study was to determine the amount of OTC residue in muscle and liver of Common carp (Cyp More

  Oxytetracycline (OTC) is the only form of tetracycline compounds which is approved by FDA to be used for prevention and treatment of aquatic animals’ diseases. The aim of this study was to determine the amount of OTC residue in muscle and liver of Common carp (Cyprinus carpio) by high performance liquid chromatography (HPLC) using single dose method. 12 fishes were divided into 4 treatments and each treatment was divided into 3 replicates. Regarding the weight range of fishes                ( 40-80 g ) and also the injectable OTC dosage rate of  25-50 mg/kg in accordance with aquatic animals pharmaceuticals ,0.04 ml of injectable solution of OTC was intramuscularly injected, then muscle and liver were sampled from fishes after 6, 24, 48 and 72 hours. Measurement of OTC residues was carried out by HPLC after solid phase extraction (SPE). The highest recorded concentrations in muscle and liver were observed in 6hr and 24hr after injection respectively (3.37μg/g and 17.37μg/g). The lowest concentrations in muscle and liver belonged to 72hr after injection (0.29μg/g and 9.52μg/g respectively). The results indicated that OTC concentrations descend in muscle from 6th to 72th hour. But in liver, because of OTC redistribution, drug concentration increases significantly after 24hr (P<0.05), then it decreases after 48 and 72hr. Manuscript profile
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  11 - SIMULATION OF TETRACYCLINE ONTO GRAPHENE NANO SHEET
  Gholamreza Soliemani Ehsan Ezzatpour Ghadim Salimeh Kimiagar
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  12 - Measuring active matter levels in original and open forms of veterinary preparations containing oxytetracycline stored under varied storage conditions
  Shahram Saghaei
  10.30495/jbcvm.2023.1987519.1044
  This study aimed to evaluate the level of active matter in oxytetracycline stored under different conditions. Analyzing the active matter content of the drug was performed in its original packaging and in opened packages that were stored at room temperature, in the dark More

  This study aimed to evaluate the level of active matter in oxytetracycline stored under different conditions. Analyzing the active matter content of the drug was performed in its original packaging and in opened packages that were stored at room temperature, in the dark, and in the refrigerator for varying periods. Oxytetracycline was used for each preparation, and the active matter quantities were analyzed after 3, 6, and 9 months using HPLC. Additionally, considering the drug's life cycle, the opened packages were also analyzed at 24 and 48 hours. Results for the drug, which contained oxytetracycline (traditional) and was stored in a normal temperature room, were respectively: (6.14 ± 0.32, 6.50 ± 0.19), (5.58 ± 0.00, 6.38 ± 0.20), and (6.08 ± 0.10, 6.45 ± 0.32) ppm. Also, the results for the drug kept in the dark and a newly unwrapped drug were respectively: (6.29 ± 0.27, 6.37 ± 0.34), (5.30 ± 0.04, 6.30 ± 0.17), and (5.97 ± 0.13, 5.86 ± 0.06) ppm. Finally, the results for the drug kept in the refrigerator and a newly unwrapped drug were respectively: (7.55 ± 0.15, 7.48 ± 0.11), (5.36 ± 0.05, 5.81 ± 0.20), and (6.06 ± 0.36, 5.72 ± 0.07) ppm. Altogether, the results indicated that several external factors, such as heat, light, humidity, and oxygen, significantly impacted drug stability. Additionally, internal factors such as the internal reaction of the active ingredient, preservatives, and solvents influenced stability. Therefore, these various factors collectively affect the half-life of oxytetracycline. Manuscript profile
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  13 - Evaluation of Tetracycline Antibiotic Residue in Honey Samples using ELISA and HPLC
  Anahita Hoseinpour Peyman Ghajarbygi Razzagh Mahmoudi Reza Norian Saeed Shahsavari
  10.22034/jchr.2020.1876259.1044
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