List of Articles Sulfadiazine

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  1 - The effect of combining mord (Myrtus communis) leaf extract and olive oil (Olea europaea) in comparison with 1% silver sulfadiazine cream on skin wound healing in Balb/c mice
  Farkhondeh Nemati Ramin Ataee Fatemeh Gorji Seyed Taleb Houseini Amin Lotfvarzi Ali Bagheri hashem abad
  Mord (Myrtus communis) is a plant with antibacterial and anti-inflammatory properties. Ointment of ethanolic extract of the leaves of the mord was prepared in olive oil in a ratio of 1: 1. Wounds developed in the full thickness of the skin in the dorsal region of the mi More

  Mord (Myrtus communis) is a plant with antibacterial and anti-inflammatory properties. Ointment of ethanolic extract of the leaves of the mord was prepared in olive oil in a ratio of 1: 1. Wounds developed in the full thickness of the skin in the dorsal region of the mice. The mice were then divided into control and experimental groups. The control group did not receive any treatment and the experimental group, which included the group receiving the combination of mord leaf extract and olive oil and the group receiving 1% silver sulfadiazine cream, were treated once a day. Finally, the percentage of recovery, average skin thickness, diameter of hair follicles, collagen formation, and angiogenesis were examined on the fifth, tenth, and fifteenth days. Data were analyzed using a one-way ANOVA test using SPSS software version 22. The results showed that the treatment with the combination of ethanolic extract of mord leaf and olive oil led to a significant increase in wound healing percentage, skin thickness, hair follicle diameter, compared to 1% silver sulfadiazine cream. There was also an increase in collagen formation and angiogenesis. These results have been a reason for accelerating the wound healing process in the samples treated with a combination of mord extract and olive oil. The results of this study showed that the use of mord leaf extract and olive oil accelerates the transition from the inflammatory stage to the stage of fibroblast hyperplasia due to the increase in collagen synthesis and blood vessels in this stage. Manuscript profile
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  2 - A comparative study of histopathological effects of aqueous extract of cinnamon and honey with sulfadiazine on skin burn wound healing in rats infected with Pseudomonas aeuroginosa
  Mohammadreza Valilou Sevda Valilou
  Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen, is the most common infective agent of burn wounds. The aim of this study was to compare the histopathological effect of a mixture of aqueous extract of cinnamon and honey with silver sulfadiazine on the healin More

  Pseudomonas aeruginosa, a ubiquitous opportunistic pathogen, is the most common infective agent of burn wounds. The aim of this study was to compare the histopathological effect of a mixture of aqueous extract of cinnamon and honey with silver sulfadiazine on the healing of Pseudomonas aeruginosa infected second grade skin burn wounds in rats. To this end, 60 male rats were randomly assigned to four experimental groups (15 rats in each group). After inducing anesthesia, second grade burn wound with the diameter of 12 mm was created in the dorsal region of rats. Then, 1.5×108 cfu/ml P. aeruginosa PA01was equally bestrewed on the wound of all rats. Every 12 hours, silver sulfadiazine (group 1), honey (group 2) and aqueous extract of cinnamon and honey (group 3) were applied to the wounds and group 4 was kept as control. On days 7, 14, and 21, five rats were selected from each group at each time point and after inducing anesthesia and measuring the diameter of the wound by coliseum, microbial and histopathological samples were taken from the wounds. Microbial studies showed that in all groups except the control group, the growth of the microbe was stopped. Histopathological observations regarding wound healing and diameter showed that there was a significant difference between treatment groups and the control group on days 7, 14 and 21 (p<0.05). On the 21st day, the extract of cinnamon and honey group had superior wound healing than silver sulfadiazine group but inferior in comparison to honey. According to the results btained, it is possible to utilize honey and mixture of aqueous extract of cinnamon and honey for treatment of infected skin burn wounds. Manuscript profile
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  3 - Evaluation of wound healing activity of Commiphoramyrrha extract compared with silver sulfadiazine on experimental skin burn healing in rat
  orly yadegar ahmad asghari saeid hesaraki
  Myrrh, a traditional herbal medicine,is derived from Commiphoramyrrha (Nees) Engl. (Burseraceae) and various other species of Commiphora. It has widely been used in different diseases in India, China, Italy and Greece. Pharmacological studies also have showed that myrrh More

  Myrrh, a traditional herbal medicine,is derived from Commiphoramyrrha (Nees) Engl. (Burseraceae) and various other species of Commiphora. It has widely been used in different diseases in India, China, Italy and Greece. Pharmacological studies also have showed that myrrh possesses multiple activities, including anti-inflammatory, cytotoxic, anesthetic, and antimicrobial effects.  There has been no report on the effectiveness of commiphoramyrrha in treating burn wound. Therefore, in this study, we compared the healing times of full thickness burn wounds in rats that received commiphoramyrrha treatment or the standard SSD treatment. This study was carried out on sixty male Wistar albino rats. Grade 3 burn wounds were created on the back of all rats. The animals were randomly divided into four groups, the first group of rats received no medication, the second group received eucerin (negative control), the third group received topical SSD group and the fourth group received 2.5% Commiphoramyrrha in eucerin base.Histological samplings were done on 7th, 14th and 21st days in each group, then all samples transported to the laboratory and H&E and trichrom staining was done. Histopatological evaluation on the 7th, 14th and 21st days showed burn healing to be better in the group which had received CommiphoraMyrrha with respect to other groups, in addition wound healing was significantly better in this group (p<0.05).  In conclusion, CommiphoraMyrrha has positive effect on burn wound healing and it is better than silver sulfadiazine in low concentration.   Manuscript profile
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  4 - بررسی میزان تأثیر اسانس گیاهان اکالیپتوس و آویشن شیرازی و عصاره آبی گیاه درمنه و ترکیب سینرژیستیک پیریمتامین_سولفادیازین بر توکسوپلاسموزیس حاد در موش Balb/c
  سید رضا حسینی آرین اسعدپور بهزادی
  مقدمه و هدف: توکسوپلاسموزیس عفونت ناشی از انگل توکسوپلاسما گوندی بوده و یکی از متداول­ترین عفونت­های انگلی انسان و سایر حیوانات خونگرم به شمار می­رود. در این مطالعه تأثیر اسانس گیاهان اکالیپتوس و آویشن شیرازی و عصاره آبی گیاه درمنه و همچنین ترکیب سینرژیستیک& More

  مقدمه و هدف: توکسوپلاسموزیس عفونت ناشی از انگل توکسوپلاسما گوندی بوده و یکی از متداول­ترین عفونت­های انگلی انسان و سایر حیوانات خونگرم به شمار می­رود. در این مطالعه تأثیر اسانس گیاهان اکالیپتوس و آویشن شیرازی و عصاره آبی گیاه درمنه و همچنین ترکیب سینرژیستیک­ پیریمتامین­_ سولفادیازین بر توکسوپلاسموزیس حاد در مدل موشی مورد بررسی قرار گرفت. روش تحقیق: به منظور بررسی اثر اسانس گیاهان اکالیپتوس و آویشن شیرازی و عصاره آبی گیاه درمنه و همچنین ترکیب سینرژیستیک­ پیریمتامین­_سولفادیازین بر توکسوپلاسموزیس حاد در مدل موشی، 44 سر موش  Balb/cبا 10000 تاکی­زوایت سویه RH توکسوپلاسما گوندی از طریق داخل صفاقی آلوده و در 11گروه 4­تائی تقسیم­بندی شدند. به 9 گروه غلظت­های mg/kg/day150،mg/kg/day 300 و mg/kg/day600 از اسانس­های اکالیپتوس و آویشن­شیرازی و عصاره آبی درمنه به فاصله 24 ساعت از آلودگی به مدت 7 روز از طریق خوراکی خورانده شد. یک گروه هم با ترکیب شیمیایی پیریمتامین(با دوز mg/kg/day10) و سولفادیازین (با دوز mg/kg/day50) به فاصله 24 ساعت از آلودگی به مدت 10 روز به صورت خوراکی تحت تیمار قرار گرفتند و یک گروه هم به عنوان شاهد بیمار در نظر گرفته شد. نتایج و بحث: نتایج نشان داد که از نظر مدت زمان بقاء تفاوت آشکاری بین گروه­های تیمار شده با اسانس و عصاره گیاهان و گروه شاهد بیمار وجود نداشت و همگی تا روز ششم تلف شدند، در­حالی­که موش­های مصرف کننده داروی شیمیایی همگی زنده ماندند و پس­ از­ آنکه مایع صفاقی و مغز یکی از موش­های این گروه به صورت جداگانه به دو گروه موش سوری سالم از طریق داخل صفاقی تلقیح شد مشاهده گردید که موش­هایی که مایع صفاقی به آن­ها تلقیح شده بود همگی زنده ماندند، در حالی­که موش­هایی که مغز به آن­ها تلقیح شده بود همگی تلف شدند. این نتیجه بیانگر آن بود که ترکیب پیریمتامین_سولفادیازین در دوز مذکور بر توکسوپلاسموزیس حاد کاملاً موثر است، ولی قادر به ریشه­کنی و از بین بردن کیست­های انگل در مغز نیست. توصیه کاربردی/ صنعتی: بهتر است­ تحقیق جامع­تری در خصوص تأثیر گونه­های مختلف این گیاهان بر روی توکسوپلاسموزیس به صورت In vitro و In vivo انجام شود تا شاید بتوان دارویی موثر و بی­خطر بر علیه توکسوپلاسموزیس در جهان ارائه نمود. Manuscript profile
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  5 - Comparison of Toltrazuril and Sulfadiazine Efficacy in Canaries (Serinus canarius) Affected by Isospora Intestinal Infection
  Hamidreza Salehi-Frooz Majid Gholami-Ahangaran Elham Moghtadaiee
  Isospora is a common intestinal parasite in ornamental birds, especially passeriformes. Isospora infection can induce enteritis and reduce digestibility and nutrient adsorption. In this study, a comparison was made between the efficiency of toltrazuril and sulfadiazine More

  Isospora is a common intestinal parasite in ornamental birds, especially passeriformes. Isospora infection can induce enteritis and reduce digestibility and nutrient adsorption. In this study, a comparison was made between the efficiency of toltrazuril and sulfadiazine on reducing Isospora oocyte shedding in infected canaries. To this purpose, a total of 165 infected canaries in 48 cages were divided into 3 groups, including control group, infected and treated with toltrazuril group, and infected and treated with sulfadiazine group. The mean oocyte shedding in groups was compared statistically before and after treatment. Results showed there is no significant difference in the rate of Isospora oocyte shedding between canaries treated with toltrazuril and those treated with sulfadiazine. Therefore, in the current conditions of Iran, toltrazuril and sulfadiazine seem to be equally effective in controlling Isospora infection in canary. Manuscript profile