List of Articles SCH23390

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  1 - The Effect of D1 Dopamine Receptor Antagonist Administration into Ba-somlateral of Amygdala on ACPA Response in Fear Memory in Male Mice
  مریم حاجیان محمدرضا زرین دست محمد ناصحی مریم بنانج
  Dopaminergic pathway has essentialrole in excitable behavior, especially fear. Cannabinoids are a class of psychoactive substances and impair memory. The aim of recent study is the effect f dopaminergic pathway in fear memory. In this research,the effect of D1 receptor More

  Dopaminergic pathway has essentialrole in excitable behavior, especially fear. Cannabinoids are a class of psychoactive substances and impair memory. The aim of recent study is the effect f dopaminergic pathway in fear memory. In this research,the effect of D1 receptor antagonist Intracerebroventricular injection dopaminergic pathway and Arachidonyl cyclopropyl amide(ACPA) as impair on fear memory, in male mice was studied. One week after surgery of groups, in fear conditioning box, percent freezing and latency to first freezing was recorded. According to tukey test statistical analysis and one-way and two-way phase 5 min and 3 min, percent freezing ACPA dose of 0.1 mg/kg compared to the control group had a significant increase in latency. The percent freezing Dose SCH23390 0.08 andmu;g/site in phase 5 min was significantly reduced in the 3min dose of 0.04 andmu;g/site significant increase in latency indicated .According to Statistical test tow-way and tukey test showed that simultaneous injection ​​of SCH23390 (0.02 andmu;g/mice) and doses of ACPA in phase 3 minutes to 5 minutes and has resulted in a significant reduction in latency and percent freezing. Results indicating that high doses of ACPA cause memory corruption and fear reduction as antagonist SCH23390 infusion D1 cause of the fear. Manuscript profile
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  2 - The Relationship Between the Effects of of Sulpride, SCH23390, and L-dopa on the Relative Gene Expression of neuropeptide Y and kisspeptin in Polycystic Ovary Syndrome (PCOS) Rat Models
  Leila Neghaddadgar Fariba Mahmoudi Saber zahri Alireza Panahi
  Polycystic ovary syndrome (PCOS) is associated with decreased dopamine release and increased secretion of GnRH, kisspeptin and neuropeptide Y (NPY).  In the present study, the effects of L-dopa and dopamine receptor antagonists were investigated on the expression o More

  Polycystic ovary syndrome (PCOS) is associated with decreased dopamine release and increased secretion of GnRH, kisspeptin and neuropeptide Y (NPY).  In the present study, the effects of L-dopa and dopamine receptor antagonists were investigated on the expression of KiSS1 and NPY genes in PCOS rats hypothalamus. Following the induction of PCOS by Estradiol Valerate inejction, 25 PCOS rats assigend to 5 groups received saline, L-dopa (100mg/kg), simultaneous injection of SCH23390 (1 mg/kg) and L-dopa (100 mg/kg),  simultaneous injection of sulpride (10 mg/kg) and L-dopa (100 mg/kg), and simultaneous injection of SCH23390 (1 mg/kg), sulpride(10 mg/kg) and L-dopa (100 mg/kg) respectively. Five intact rats received saline. Hypothalamus samples were isolated and frozen. The relative expressions of KiSS1 and NPY were determined by real- time-PCR. Data analysis was done by one- way ANOVA and post hoc Tukey test. The mean relative expression of KiSS1 and NPY significantly increased in PCOS group compared to the healthy rat group (p = 0.009 and p = 0.001, respectively). L-dopa injection caused a significant decrease in the mean relative expression of KiSS1 and NPY compared to the PCOS group (p = 0.001 and p = 0.001 respectively). Simultaneous injections of SCH23390 and sulpride supressed the inhibitory effects of L-dopa on KiSS1 gene expression compared to L-dopa group exerting synergistic effects (p = 0.045).  Dopaminergic signaling pathway may play a role in the decrease of GnRH/LH secretion in PCOS rats by inhibiting the kisspeptin and NPY neuronal activity. Manuscript profile