Inroduction and Objective: Nuroglia or glial cells are non-polar cells that are responsible for metabolic function and physical support. Proliferation of glial cells is answering the obvious signs of CNS to environmental damage. Yarrow is a plant belonging to the family More
Inroduction and Objective: Nuroglia or glial cells are non-polar cells that are responsible for metabolic function and physical support. Proliferation of glial cells is answering the obvious signs of CNS to environmental damage. Yarrow is a plant belonging to the family Asteracea that contain antioxidant, anti-inflammatory and anti- apoptosis component. The aim of this study was to determine the protective effects of Achillea biebersteinii leaves alcoholic extract on spinal cord neuroglia cell after sciatic nerve compression in rats.Materials and Methods:30male Wister rats were divided randomly in groups (control,comperession, comperession+ treatment). Sciatic nerve was exposed to compression for 60 s using lockerpincers. Extract injection was done intra peritoneally in the first and second weekwith 50, 75, 100 mg/kg dose after compression. Then 28 days after compression under profusion method the lumber spinal cord was sampled. After cutting and coloring, the density of motoneurons was measured using dissector methods. The numerical density in each group compare with each other.Results: According to results, neurglia density shows meaningful increase between compression and control groups (PConclusion: It seems that alcoholic extracts of Achillea biebersteinii leaves have probably growth factors, regeneration factors and decrease neuralgia density because of anti inflammation effect
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Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta More
Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta through a 30-gauge cannula. The group control1 received saline on the left side of the Substantia Nigra pars compacta.Then, to investigate the effect of the Naringenin, group control2 received distilled water and other groups received Naringenin via gavage for two weeks, and apomorphine induced rotation, catalepsy, and behavioral tests were assessed in all groups. Hematoxylin and eosin staining was performed and the percentage of the neurons on the left side of the Substantia Nigra pars compacta were calculated. In this study, in cell culture model, dopaminergic-like neurons cultured in DMEM medium were counted, and cells were used and incubated to evaluate the effect of naringinin against 6-hydroxy dopamine. Concentrations were 50 for 6-hydroxy dopamine solution and 0.25, 0.1 and 0.01 for NAR solution. Finally, cell viability was assessed using MTT and trypan blue methods.Results: 6-Hydroxy dopamine increased catalepsy and contralateral turns compared to the control group. Naringin reduced catalapsy and contralateral turns, it reduced anxiety and depressive-like behaviours besides that it increased swimming time and locomotor activity compared to the control group. Conclusion: it seems that Naringin is a therapeutic option for neurodegenerative disorders, such as Parkinson's disease.
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Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. Substance P-mediated inflammation is reported to attenuate the neuroprotective PPAR-γ. In This study, we determined the effects of aprepitant, More
Cerebral ischemia/reperfusion (I/R) injury is a critical factor leading to a poor prognosis for ischemic stroke patients. Substance P-mediated inflammation is reported to attenuate the neuroprotective PPAR-γ. In This study, we determined the effects of aprepitant, a substance P-NK1 receptor antagonist in bilateral common carotid arteries occlusion (BCCAO) induced I/R brain injury. 24 male Wistar rats were divided into4 groups ( Control- Ischemia - Vehicle and experimental). Ischemia model was induced by ligation of bilateral common carotid arteries. Aprepitant (40mg/kg) was administered twice, one hour beforethe ischemia and one hour after the reperfusion. After 72 hours, Brains were removed and prepared for Nissl staining.Data depicted that significant differences were seen in the number of viable Pyramidal cells in CA1 region between control and ischemia groups whereas there are no significant deference between experimental and control groups.It may be concluded that aprepitant can reduce post-ischemic tissue lesions, so may candidate for the treatment of I/R brain damage.
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