The protective effects Of alcoholic extracts Of Achillea biebersteinii leave ondensity neuroglia cell spinal cord after the sciatic nerve compression in rats.
Subject Areas :
Mahbobeh
Alikhanzadeh
1
(دانشگاه آزاد اسلامی واحد مشهد، کارشناسی ارشد زیست شناسی علوم جانوری گروه زیست شناسی، مشهد. ایران.)
Maryam
Tehranipour
2
(دانشگاه آزاد اسلامی واحد مشهد، دانشیار فیزیولوژی جانوری گروه زیست شناسی، مشهد. ایران)
Jina
Khayyatzade
3
(دانشگاه آزاد اسلامی واحد مشهد، استادیارتکوین جانوری گروه زیست شناسی، مشهد. ایران.)
Keywords: Neuroprotective, Achillea biebersteinii, Sciatic Nerve, Neurglia,
Abstract :
Inroduction and Objective: Nuroglia or glial cells are non-polar cells that are responsible for metabolic function and physical support. Proliferation of glial cells is answering the obvious signs of CNS to environmental damage. Yarrow is a plant belonging to the family Asteracea that contain antioxidant, anti-inflammatory and anti- apoptosis component. The aim of this study was to determine the protective effects of Achillea biebersteinii leaves alcoholic extract on spinal cord neuroglia cell after sciatic nerve compression in rats.Materials and Methods:30male Wister rats were divided randomly in groups (control,comperession, comperession+ treatment). Sciatic nerve was exposed to compression for 60 s using lockerpincers. Extract injection was done intra peritoneally in the first and second weekwith 50, 75, 100 mg/kg dose after compression. Then 28 days after compression under profusion method the lumber spinal cord was sampled. After cutting and coloring, the density of motoneurons was measured using dissector methods. The numerical density in each group compare with each other.Results: According to results, neurglia density shows meaningful increase between compression and control groups (PConclusion: It seems that alcoholic extracts of Achillea biebersteinii leaves have probably growth factors, regeneration factors and decrease neuralgia density because of anti inflammation effect
