List of Articles Nepetalacton

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  1 - Study of qualitative and quantitative changes in Nepeta crispa Willd. essential oil in natural habitats and agronomical conditions
  Mohammad Karami Mohammad-Taghi Ebadi Mahdi Ayyari
  Nepeta crispa Willd. Locally known as Mofarrah belongs to Lamiaceae family. It is an Iranian endemic self-growing medicinal plant to Alvand Mountains in Hamadan province. N. crispa has carminative, anti-inflammatory, antinociceptive, antibacterial and antifungal propert More

  Nepeta crispa Willd. Locally known as Mofarrah belongs to Lamiaceae family. It is an Iranian endemic self-growing medicinal plant to Alvand Mountains in Hamadan province. N. crispa has carminative, anti-inflammatory, antinociceptive, antibacterial and antifungal properties. The aim of this study was to investigate the phytochemical composition of essential oil compounds of this plant in the vegetative stage, which cultivated in Tarbiat Modares University of Tehran at an altitude of 1283 m above sea level, and compare with samples taken from natural habitats in Arzanfood and Gashani with the altitude of 3015 and 2489 m above sea level, respectively. The plants were harvested during the late July 2018. The essential oils of all samples were obtained by hydrodistillation and were analyzed by GC-MS and GC-FID. The yield of essential oil in the sample collected from Arzanfood, Gashani and field samples were 2.13, 1.97 and 0.55% (w/w), respectively. Twenty components were identified among the samples, representing 93-96% of the oils. The main components were 1, 8-cineole (40.25%, 48.5, 49.9%), 4aα, 7β, 7aα-nepetalactone) 34.8%, 3.7%, 24.7%) and β- pinene) 6.2%, 5.4%, 5.4%) for cultivated field, Gashani and Arzanfood samples, respectively. Although the percentage of oil and 1, 8-cineole in the cultivated sample were low, but the amount of nepetalactome compounds was high. According to the results, the environmental conditions had an important role in the qualitative and quantitative changes in the essential oil of this plant but cultivation of N. crispa in a place with more than 1200 m difference in altitude, lower than the main habitat, was a promising sign for domestication of N. crispa. Optimization of other factors including, cultivation in an area close to the natural habitat, nutrition, biotic and abiotic stresses treatment could even improve the quality of this plant compared to the self-growing ones. Manuscript profile
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  2 - The investigation of essential oil composition in Nepeta cephalotes Boiss. and Nepeta gloeocephala Rech.f. in dry and wet conditions
  Merdokht Najafpour Navaei, mehdi mirza
  Nepeta cephalotes Boiss. and Nepeta gloeocephala Rech.f. are the exclusive species ,which are distributed in Irano-Turani region from Iran. The purpose of this study was identifying the comparision of essential oil composition from these two species in fresh and dry con More

  Nepeta cephalotes Boiss. and Nepeta gloeocephala Rech.f. are the exclusive species ,which are distributed in Irano-Turani region from Iran. The purpose of this study was identifying the comparision of essential oil composition from these two species in fresh and dry conditions. The aerial parts of N. gloeocephala in blooming were gathered from kashsn habitat in Ghamsar and Ghohrood (1700 m) and N.cephalotes were collected from Damavand by the river (1500 m) in May and June 2015, respectively. The essential oils were obtained in fresh and dried conditions by hydro distillation (Clevenger apparatus) and were analyzed by (GC) and (GC-MS). The results were showed that the yield of essential oils of both species in dry condition was higher than fresh condition. In Nepeta gloeocephala 29 compounds were identified, which that the 1,8-cineoles (28.9%, 36.5%)  had the highest percentage in wet and dry condition, respectively, but in Nepeta cephaloutes 17 compounds were identified, which that 4aα, 7α, 7aα neptata-lactone (wet 43%, dry 64%) were the highest amount in dry condition.Nepeta cephalotes Boiss. and Nepeta gloeocephala Rech.f. are the exclusive species ,which are distributed in Irano-Turani region from Iran. The purpose of this study was identifying the comparision of essential oil composition from these two species in fresh and dry conditions. The aerial parts of N. gloeocephala in blooming were gathered from kashsn habitat in Ghamsar and Ghohrood (1700 m) and N.cephalotes were collected from Damavand by the river (1500 m) in May and June 2015, respectively. The essential oils were obtained in fresh and dried conditions by hydro distillation (Clevenger apparatus) and were analyzed by (GC) and (GC-MS). The results were showed that the yield of essential oils of both species in dry condition was higher than fresh condition. In Nepeta gloeocephala 29 compounds were identified, which that the 1,8-cineoles (28.9%, 36.5%)  had the highest percentage in wet and dry condition, respectively, but in Nepeta cephaloutes 17 compounds were identified, which that 4aα, 7α, 7aα neptata-lactone (wet 43%, dry 64%) were the highest amount in dry condition. Manuscript profile
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  3 - ترکیبات شیمیایی و فعالیتهای بیولوژیکی Nepeta hindostana (Roth) Haines، Nepeta graciliflora Benth. و Nepeta cataria L. از هند
  مونیکا جوشی راوندرا کومار ام پراکاش آنیل پانت D. راوات
  10.30495/medherb.2021.683393
  Background & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present st More

  Background & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present study was to evaluate the chemical composition and biological activities of the essential oils from three species of genus Nepeta viz: Nepeta hindostana (Roth) Haines (NHO), Nepeta graciliflora Benth (NGO) and Nepeta cataria L (NCO). Experimental: The essential oils were analysed by the combination of GC and GC-MS. Antioxidant activity was tested by using reducing power assay, metal chelating of Fe2 +assay, and DPPH radical scavenging assay. In-vitro antinflammatory activity was evaluated using albumin denaturation assay and anti-diabetic activity was determined by using α-amylase assay. Results: The major components present in NCO, NHO and NGO were cis-nepetalactone (69.78%), β-farnesene (43.41%) and sesquisabinene (28.75%), respectively. NCO showed the highest percentage inhibition of DPPH radical (IC50=5.89 µl/ml) followed by NHO (IC50=8.63 µl/ml) and then NGO (IC50=13.81 µl/ml). In terms of reducing power assay and metal chelating of Fe2+  assay, the highest antioxidant activity was also shown by NCO. Among the tested essential oil, NCO showed highest in-vitro anti-inflammatory potential (IC50 18.463±0.14 µg/ml) followed by NGO and NHO with IC50 22.035±0.11 µg/ml and 26.17±0.14 µg/ml, respectively. NHO showed maximum antidiabetic activity with IC50 8.92±0.10 µg/ml of α-amylase. Recommended applications/industries: On the basis of present research work it is marked that the essential oil of Nepeta hindostana (Roth) Haines, Nepeta graciliflora Benth. and Nepeta cataria L. is a potent antioxidant, anti-inflammatory and anti-diabetic agent indicating their potentiality in the field of food, pharmaceutical and cosmetic industry. Manuscript profile