List of Articles Ki-67

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  1 - Evaluation of the effect of aflatoxin B1 on neuronal differentiation and hippocampal development in rats
  سارا Alhoei Nazari Nasim Hayati Roodbari , K Parivar , A. Eidi
  Aflatoxin B1 has harmful effects on the nervous-cerebral system. Therefore, in this study the effects of Aflatoxin B1 on the development of the hippocampus of neonatal rats were investigated. After the preparation of Aflatoxin B1, 18 pregnant female Wistar rats with an More

  Aflatoxin B1 has harmful effects on the nervous-cerebral system. Therefore, in this study the effects of Aflatoxin B1 on the development of the hippocampus of neonatal rats were investigated. After the preparation of Aflatoxin B1, 18 pregnant female Wistar rats with an average weight of 85±10 g were used. Animals were divided into three groups: sham (receiving sesame oil as a solvent of Aflatoxin B1), Aflatoxin B1 and Healthy control. According to the results of immunohistochemical studies, Aflatoxin B1 treated groups showed a statistically significant decrease in Ki-67 and NeuN expression compared to the control group (P <0.01). While the expression level of the GFAP in comparison with the control group had a statistically significant increase (P <0.01). On the other hand, a significant decrease in the expression of NeuN and Ki-67 proteins and an increase in the expression of GFAP were observed, which were confirmed by observations from fluorescent immunohistochemical imaging. Aflatoxin B1 disrupts neuronal differentiation and increases brain damage by disrupting the activity and expression of vital proteins in the hippocampus, which was demonstrated by a sharp decrease in NeuN and an increase in GFAP. Manuscript profile
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  2 - Observation of anti-cancer effects of aflatoxin B1 in breast tumor category 4T1 of mice by injection around the tumor
  R. Mousazadeh, S. Hesaraki, M. Bayat, A. Jahandideh, J. Hashemi,
  Treatment of breast cancer has many problems due to the systemic effects of chemotherapy. The use of certain molecules with cell killing effects, such as aflatoxin B1, can have fatal effects on breast cancer cells. In this study, we investigated the inhibitory effect of More

  Treatment of breast cancer has many problems due to the systemic effects of chemotherapy. The use of certain molecules with cell killing effects, such as aflatoxin B1, can have fatal effects on breast cancer cells. In this study, we investigated the inhibitory effect of topical aflatoxin B1 use on breast cancer. Class 4T1 cancer cells were inoculated subcutaneously in female mice. Doses of 50 and 500 μg / ml of aflatoxin B1 were then injected around the tumors in comparison with doxorubicin. The ratio of tumor size to animal weight in different groups was evaluated along with histopathology by immunofluorescence on Ki-67 and VEGF indices. Aflatoxin B1 significantly reduces tumor volume, necrosis and suppresses angiogenesis in the tumor. However, liver metastasis occurred in all groups. Aflatoxin B1 in topical injections of 50 and 500 μg / ml around the tumor has anti-cancer effects on the breast. But it can not prevent metastasis.Aflatoxin-induced hepatotoxicity was also observed. Manuscript profile