List of Articles IL-4

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  1 - Effect Shrak cartilage on number and activity T-cell regulating cells in stomach cancer paitents
  razieh zareii محمد زهیر حسن صراف ابوالقاسم عجمی داریوش مسلمی امراله مصطفی زاده
  Introduction: Gastric cancer or gastric cancer, the fourth most common cancer and the second most common cancer in Iran and around the world Srtankshndh safety Ast.paskhhay in gastric cancer include innate and adaptive immunity Treg The cells in several malignancies inc More

  Introduction: Gastric cancer or gastric cancer, the fourth most common cancer and the second most common cancer in Iran and around the world Srtankshndh safety Ast.paskhhay in gastric cancer include innate and adaptive immunity Treg The cells in several malignancies including gastric cancer in Myyabdslvlhay increase in Treg immune response settings, maintaining homeostasis and immune tolerance, autoimmunity and cancer survival primarily as a treatment for cancer control Myknd.ghzrvf shark is .. Shark cartilage, a protein that angiogenesis (angiogenesis) in vitro and stop animal models. A network of blood vessels tumors need to survive and grow, so by blocking the blood supply to the tumor disappears,It was observed that in the group treated with shark cartilage cell viability Treg an average of 48/1% before treatment to 2/0% post treatment decrease the amount of cytokine inhibition of TGF-β from pg / ml183 before treatment pg / ml110 after treatment decreased, but the amount of cytokines in serum IFN-γ (pattern of cytokine TH1) of pg / ml160 before treatment pg / ml187 after treatment increased the amount of IL-4 (pattern of cytokine TH2) of pg / ml37 before treatment pg / ml30 after treatment decreased Is. In the control group there was no significant difference in the measurement.Final argument: Shark cartilage in people suffering from gastric cancer cell depletion inhibitory Treg and cytokine inhibiting TGF-β as well as a reduction in IL-4 (Aymvnyty cells, TH2) and increased production of IFN-γ (Aymvnyty cells, TH1) to enhance immune responses anti-tumor cell. Manuscript profile
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  2 - Resistance training with nanocurcumin on IL-4 and STAT-6 gene expression in muscle cells of healthy male rats
  Sadra Sheidaei Shahin Riyahi Malayeri Masoumeh Hosseini
  زمینه و هدف: محور پیام‌دهی IL4/STAT-6 یکی از مهم‏ترین مسیرهای مهم درگیر در رشد و توسعه سرطان می‌باشد. هدف از پژوهش حاضر بررسی تاثیر تمرین مقاومتی همراه با مصرف نانوکورکومین بر IL-4 و STAT-6 در سلول های ضلانی رت های نر سالم بود. مواد و روش ها: در این مطالعه تجربی، 32 More

  زمینه و هدف: محور پیام‌دهی IL4/STAT-6 یکی از مهم‏ترین مسیرهای مهم درگیر در رشد و توسعه سرطان می‌باشد. هدف از پژوهش حاضر بررسی تاثیر تمرین مقاومتی همراه با مصرف نانوکورکومین بر IL-4 و STAT-6 در سلول های ضلانی رت های نر سالم بود. مواد و روش ها: در این مطالعه تجربی، 32 سر رت نر نژاد ویستار به طور تصادفی به چهار گروه (کنترل، تمرین مقاومتی، نانوکورکومین، تمرین مقاومتی+ نانوکورکومین) تقسیم شدند. برنامه تمرینی به مدت 4 هفته و 3 جلسه در هر هفته اجرا شد. گروه های دریافت کننده مکمل روزانه 80 میلی گرم نانوکورکومین به ازای هر کیلوگرم وزن بدن به مدت 4 هفته به صورت خوراکی (گاواژ) دریافت کردند. بیان ژنIL-4 و STAT-6 با روش Real-time PCR اندازه گیری شد. داده ها با استفاده از آزمون تحلیل واریانس یک طرفه مورد بررسی قرار گرفتند.یافته ها: نتایج نشان داد تمرین مقاومتی همراه با مصرف نانوکورکومین موجب افزایش معنادار IL-4 نسبت به سایر گروه ها و کاهش STAT-6 نسبت به گروه تمرین سلول عضلانی رت های نر سالم شد(05/0>P ).نتیجه گیری: به نظر می‏ رسد چهار هفته تمرین مقاومتی همراه با مصرف مکمل نانوکورکومین احتمالا با تاثیر بر محور پیام دهی IL-4/STAT-6 می تواند به تنهایی در روند کاهش آن موثرتر باشد. Manuscript profile
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  3 - The effect of weakening the immune system with the drug dexamethasone and high intensity interval training on the maturation of T lymphocytes in the thymus.
  yaser kazemzadeh pegah hooshangi
  10.30495/pah.2023.1988370.1044
  Background and purpose: The thymus is a specialized lymphatic organ in the immune system and plays a vital role in the normal functioning of the immune system. It was observed that 24 and 48 hours after dexamethasone consumption, thymocytes decrease by 55 and 84%, respe More

  Background and purpose: The thymus is a specialized lymphatic organ in the immune system and plays a vital role in the normal functioning of the immune system. It was observed that 24 and 48 hours after dexamethasone consumption, thymocytes decrease by 55 and 84%, respectively, which can be associated with a decrease in the ability of the thymus to mature and differentiate T lymphocytes. The aim of the present study was to investigate the effect of 4 weeks of high intensity interval training on IL-4 and IFN-γ gene expression in the thymus tissue of rats with dexamethasone-induced immune system weakness.Materials and methods: The research samples in the present study consisted of 24 male Wistar rats, which were randomly divided into 3 groups: healthy control group, immunocompromised control group, immunocompromised group + intense periodic activity. Weakening of the immune system of the samples was done by injecting dexamethasone for three days, and high intensity interval training was done for 5 sessions per week, at 85% of the VO2max speed of the samples, for 4 weeks. The data were analyzed using one-way analysis of variance and Tukey's post hoc test at the level of α ≥0.05.Findings: The data showed that the expression of IFN-γ and IL4 gene decreased with dexamethasone injection compared to the control group (p=0.0001), also performing intense intermittent exercise led to a further decrease in IFN-γ and IL4 gene expression in the thymus tissue, but This reduction was not significant (p=0.151).Conclusion: In the present study, it was found that dexamethasone reduces the function of the thymus in the production of inflammatory and anti-inflammatory cytokines, thereby reducing their function in the maturation of lymphocytes. Key words: high intensity interval training, IL-4, IFN-γ, dexamethasone Manuscript profile
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  4 - Dynamics and Separation-based Adsorption of Binary Mixtures of CH4, CO2 and H2S on MIL-47: GCMC and MD Studies
  Abbas Shahsavani Zohreh Ahadi Vahid Sokhanvaran Maryam Taghizadeh Mosfata Hadei Muhammad Shadman Lakmehsari
  10.22034/jna.2018.579591.1118
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  5 - Dynamics and Separation-based Adsorption of Binary Mixtures of CH4, CO2 and H2S on MIL-47: GCMC and MD Studies
  Abbas Shahsavani Zohreh Ahadi Vahid Sokhanvaran Maryam Taghizadeh Mostafa Hadei Muhammad Shadman Lakmehsari
  10.22034/jna.2019.664503
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