The effect of weakening the immune system with the drug dexamethasone and high intensity interval training on the maturation of T lymphocytes in the thymus.
Subject Areas : Physical Activity and Healthyaser kazemzadeh 1 , pegah hooshangi 2
1 - Member of the academic faculty of Islamic Azad University, Islamshahr branch
2 - Islamic Azad University, Tehran-shomal Branch
Keywords: T lymphocytes, High Intensity Interval Training, dexamethasone, Thymus,
Abstract :
Background and purpose: The thymus is a specialized lymphatic organ in the immune system and plays a vital role in the normal functioning of the immune system. It was observed that 24 and 48 hours after dexamethasone consumption, thymocytes decrease by 55 and 84%, respectively, which can be associated with a decrease in the ability of the thymus to mature and differentiate T lymphocytes. The aim of the present study was to investigate the effect of 4 weeks of high intensity interval training on IL-4 and IFN-γ gene expression in the thymus tissue of rats with dexamethasone-induced immune system weakness.Materials and methods: The research samples in the present study consisted of 24 male Wistar rats, which were randomly divided into 3 groups: healthy control group, immunocompromised control group, immunocompromised group + intense periodic activity. Weakening of the immune system of the samples was done by injecting dexamethasone for three days, and high intensity interval training was done for 5 sessions per week, at 85% of the VO2max speed of the samples, for 4 weeks. The data were analyzed using one-way analysis of variance and Tukey's post hoc test at the level of α ≥0.05.Findings: The data showed that the expression of IFN-γ and IL4 gene decreased with dexamethasone injection compared to the control group (p=0.0001), also performing intense intermittent exercise led to a further decrease in IFN-γ and IL4 gene expression in the thymus tissue, but This reduction was not significant (p=0.151).Conclusion: In the present study, it was found that dexamethasone reduces the function of the thymus in the production of inflammatory and anti-inflammatory cytokines, thereby reducing their function in the maturation of lymphocytes. Key words: high intensity interval training, IL-4, IFN-γ, dexamethasone
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