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Open Access Article
1 - Diagnosis of hyperlipidemia in patients based on an artificial neural network with pso algorithm
asma naeimi minoo soltanshahi amir rajabi -
Open Access Article
2 - Histopathological comparison of the effect of Salvia sharifi and Salvia virgata extracts on hyperlipidemia in adult male rat
Shahraki Mojahed, L., Davari, S.A.*, Hajinezhad, M.R. .This study was aimed to compare the effects of Salvia Sharifi and Salvia Virgata on serum lipids and histopathology of liver in hyperlipidemic rats. Forty male adult Wistar rats were distributed into four groups as follow: (1) control, (2) hyperlipidemic rats, (3) hyper MoreThis study was aimed to compare the effects of Salvia Sharifi and Salvia Virgata on serum lipids and histopathology of liver in hyperlipidemic rats. Forty male adult Wistar rats were distributed into four groups as follow: (1) control, (2) hyperlipidemic rats, (3) hyperlipidemic rats received hydroalcoholic extract of S. Virgata (200 mg/kg bw) and (4) hyperlipidemic rats received hydroalcoholic extract of S. Sharifi (200 mg/kg bw). A high-fat diet was administered to rats for one month.Then, two rats were selected from each diet group and hyperlipidemia was confirmed by measurement of serum triglyceride and serum cholesterol levels. Groups 3&4 were orally treated by S. Virgata and S. Sharifi respectively for 21 days. At the end of the experiment, blood samples were obtained by heart puncture and used to determine serum triglyceride, cholesterol, HDL and LDL levels and liver specimens were obtained for histopathological investigations. The data were analyzed by one-way ANOVA and Tukey's post hoc test. The results showed that S. Sharifi extract significantly reduced serum triglyceride, cholesterol and LDL levels and increased serum HDL compared to untreated hyperlipidemic rats. Treatment with S. Virgata reduced serum triglyceride, cholesterol and LDL levels but serum HDL of rats in this group had no significant effect in comparison to hyperlipidemic group. In addition, S. Sharifi extract decreased hepatic lesions in comparison to hyperlipidemic rats received S. virgata. These results showed the protective effect of S. Sharifi and S. Virgata extracts on hyperlipidemia-induced liver injury and this protection was more pronounced in the group received S. Sharifi. Manuscript profile -
Open Access Article
3 - Hypolipidemic effect of dill essential oil in hyperlipidemic rats
Tayebeh Moradkhani Maryam Eidi Alireza SaeediniaHyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including nor MoreHyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of essential oil dill on the lipid profile in hyperlipidemic rats. Thirty-six adult male rats were divided into 6 groups including normal group, control hyperlipidemic group (received 10% lipid in food), hyperlipidemic rats (received atorvastatin at dose of 10 mg/kg, daily) and experimental hyperlipidemic rats (received essential oil of dill at doses 0.5, 1 and 2 ml/kg, daily). After 8 weeks and 12 h fastening, the animals were weighted and anesthetized by ether. The blood and liver sampling was done. The serum cholesterol, triglyceride, LDL, HDL, VLDL, AST and ALT levels were measured by kit. The liver sections were stained by haematocilin-eosin method. The result showed that oral treatment of atorvastatin and essential oil of dill decreased weight gain, serum cholesterol, triglyceride, LDL, VLDL, AST and ALT levels and liver damaged, while increased serum HDL level in experimental rats in comparison to control hyperlipidemic rats, significantly. So, essential oil of dill improved lipid profile in hyperlipidemic animal and has antioxidant effect with improving liver tissue and function. Manuscript profile -
Open Access Article
4 - Hypolipidemic effect of fenugreek (Trigonella foenum-graecum L.) on serum lipid profile and PPAR-gamma gene expression in adipose tissue of hyperlipidemic male rats
Maryam Eidi Mahdieh MohseniHyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of hydro-methanolic extract of fenugreek on the serum lipids and PPAR-gamma gene expression in the adipose tissue of hyperlipidemic ra MoreHyperlipidemia is one of the most important risk factors of cardiovascular disease. The aim of present study was to evaluate the effect of hydro-methanolic extract of fenugreek on the serum lipids and PPAR-gamma gene expression in the adipose tissue of hyperlipidemic rats. Thirty-six adult male rats randomly were divided into 6 groups including normal group, control hyperlipidemic group (received 10% lipid in food), positive control hyperlipidemic rats (received atorvastatin at dose of 10 mg/kg, daily) and experimental hyperlipidemic rats (received extract at doses 100, 200 and 400 mg/kg, daily). After 8 weeks and 12 h fastening, the animals were weighted and anesthetized by ether. The liver was removed and weighted. The blood and adipose tissue sampling were done. The weight gain, liver index, serum cholesterol, triglyceride, LDL, HDL, AST and ALT levels were measured by kit and PPAR-gamma gene expression in the adipose tissue was evaluated by real-time PCR. The results showed that oral treatment of atorvastatin and extract of fenugreek decreased weight gain, serum cholesterol, triglyceride, LDL, AST and ALT levels and PPAR-gamma gene expression in adipose tissue, while increased serum HDL level in experimental hyperlipidemic rats compared to control hyperlipidemic rats, significantly. So, the extract of fenugreek improved lipid profile and then down-regulated PPAR-gamma gene expression in adipose tissue. Manuscript profile -
Open Access Article
5 - Nutraceutical Potential of Tetracarpidium conophorum and Buccholzia coriacea in Diet-induced Hyperlipidemia
Eucharia Oluchi Nwaichi Justice Obinna Osuoha Michael Okechukwu Monanu -
Open Access Article
6 - The Effects of Soy Milk on Serum Lipid Profile in Hyperlipidemia Menopause Women in Shiraz
خاطره صفوی نائینیCardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most i MoreCardiovascular disease is related with various risk factors. The most important of these are age. Coronary arterial disease mortality is increased after menopause. It is due to hypoestrogenemia. Soy bean is a source of fetoestrogen that is similar to hormone. The most important fetoestrogen is isoflavone. Soy bean is source of isoflavone that can decrease serum total cholesterol so protect of heart disease.In this randomized clinical trial 50 menopause women with hyper lipidemia and inclusion criteria were chosen. They were divided randomly to two groups (control and soya milk) diet. In soya milk group they were given 1 liter soya milk every day for 12 weeks. In control group they were not given soya milk or any product of soya. Initial and after 12weeks they were assayed for serum lipids profile. Data were collected and analyzed by SPSS software. There were no significant changes in serum lipids profile (triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within control group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol) within soya milk group Initial and after 12 weeks (P=NS). There were no significant changes in serum lipids profile) triglyceride, HDL-cholesterol, LDL-cholesterol, total cholesterol)between soya milk group and control group Initial and after 12weeks (P=NS).It seems soy milk has no actually effects on serum lipids profile, therefore this subject need to additional studies. Manuscript profile -
Open Access Article
7 - Antidiabetic Potential of Saponin and β-carotene in Alloxan Induced Diabetic Rats
Arezu Marefat Leila SadeghiDiabetes Mellitus is a chronic metabolic disorder characterized by hyperglycemia and accompanied by some abnormalities in pancreatic and hepatic tissue. Previous studies approved some chemicals damaging the pancreatic tissue and disturbing insulin release such as alloxa MoreDiabetes Mellitus is a chronic metabolic disorder characterized by hyperglycemia and accompanied by some abnormalities in pancreatic and hepatic tissue. Previous studies approved some chemicals damaging the pancreatic tissue and disturbing insulin release such as alloxan and streptozocin, besides creating diabetic signs like hyperglycemia, hyperlipidemia, inflammation, and oxidative stress. Moreover, its possible natural compounds used traditionally as antioxidant or anti-obesity have antidiabetic effects. Therefore, this study investigated the effects of oral administration of saponin and β-carotene on biochemical, immunological, and histological properties of pancreas related to alloxan-induced diabetic rats. Results confirmed hyperglycemia and hyperlipidemia imposed by alloxan accompanied by oxidative stress and inflammation and controlled by phytochemical treatment. Overall phytochemicals improved inflammation imposed by oxidative stress in alloxan-treated rats and decreased degeneration in pancreatic tissue leading to improved Langerhans islet and causing regular and normal release of insulin. Insulin triggers glucose and lipids absorbance and relives lipoprotein profile disruption seen in diabetic rats. By considering similarity between alloxan-induced diabetes in rats and diabetic patients, saponin and β-carotene or related chemically modified compounds could be used in lowering diabetes risk and treatment of patients suffering from diabetes or other metabolic disorders. Manuscript profile -
Open Access Article
8 - Effects of Combined Extracts of Allium sativum and Citrus limon on Atherosclerosis Inflammatory Risk Factor (hs-CRP) in Male Wistar Rats under High-fat Diet
P. Baradaran Khalkhali S.A. Haeri Rouhani P. YaghmaeeCardiovascular disease, which includes atherosclerosis, is one of the major diseases in the world. High sensitive C-reactive protein is the most sensitive inflammatory marker that recently its serum level predicts risk of cardiovascular disease is suggested. Both garlic MoreCardiovascular disease, which includes atherosclerosis, is one of the major diseases in the world. High sensitive C-reactive protein is the most sensitive inflammatory marker that recently its serum level predicts risk of cardiovascular disease is suggested. Both garlic (Allium sativum) and lemon (citrus limon) are used in the traditional management of CVD without a scientific evidence of the benefit of their combination. This study designed to investigate the hypolipidemic and anti-inflammatory effects of combined extracts of A. sativum and C. limon in male Wistar rats after high-fat diet for eight weeks. For this purpose, 42 adult male rats of Wistar strain, with weights between 200 and 250 gr, were divided into six groups (n=7). Group control and Exp3 was fed on normal pellet diet while group control fat, Sham, Exp1 and Exp2 fed on high-fat diet for up to 8 wk. The combined extract was administered to rats in graded doses for 4 wk and blood serum was analyzed for C-reactive protein and total cholesterol.Results are expressed as means ± SE. Significance differences of biochemical measurements were analyzed by using repeated measure and ANOVA tests to identify differences in phases and among groups. When appropriate, a Tukey posthoc was applied. Statistical significance was accepted at PA. sativum and C. limon was recognizable. However, future long-term well-designed investigations would provide valuable information to establish public health recommendations on the combined extract, taking into account both the nature of the compounds and the optimal dose, for cardiovascular health protection Manuscript profile -
Open Access Article
9 - Evaluation of hyperlipidemia in patient with hypertension refered to hospitals of Azad university of Mashhad in 86-87
Mahdi Masumian Mohamad Sarafraz yazdi Golnoosh GhooshchiAims: About a quarter of adult people (60 million in USA and 1 billion all over the world) suffer arterial blood pressure. Hypertension is the main reason of mortality around the world and is a big trouble in public health. Whereas the lipids such as total cholesterol, MoreAims: About a quarter of adult people (60 million in USA and 1 billion all over the world) suffer arterial blood pressure. Hypertension is the main reason of mortality around the world and is a big trouble in public health. Whereas the lipids such as total cholesterol, triglyceride, HDL and LDL concern in atherosclerosis which are followed by cardiovascular disorders, we conducted to evaluation of hyperlipidemia in the high arterial blood pressure patients. Method: We carried out our thesis by observational case-control method and we studied 400 patients who refer to the cardiac and internal clinics of Azad University Hospitals of Mashhad during 2007-2008. We divided the patients to 2 groups: 200 patients for control (with normal blood pressure) and 200 patients for case group (high blood pressure). We recorded clinical and demographic information by a questionnaire and then a lipid profile test (cholesterol, triglyceride, HDL and LDL) was done. Results: According to the results there is a significant difference in the levels of total cholesterol and triglyceride between 2 groups (Pvalue= 0.0001). But there is not a significant difference for HDL (Pvalue= 0.692).A bout LDL there is a significant difference between 2 groups. (Pvalue= 0.001). Due to ‍confounding factors such as age, occupation and etc there is no significant difference in a multi-variable logistic regression model in all lipids except triglyceride between 2 groups.(total cholesterol (Pvalue= 0.240), triglyceride (Pvalue= 0.027) , LDL(Pvalue= 0.249), HDL (Pvalue= 0.906)). Discussion: Statistical results showed that there is a significant relation between hypertrigliceridemia and hypertension, but other lipids with notice to confounding factors need to accompariment other risk factors until can be predisposal factors for hypertension. Manuscript profile
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