List of Articles Hepatoprotective

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  1 - مروری بر اثرات محافظت کبدی Nigella sativa L.
  مهرداد استادپور مجید غلامی آهنگران
  10.30495/medherb.2021.681959
  Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use of N. Sativa seeds and oil in traditional remedies goes back more than 2000 years, and the herb More

  Background & Aim:Nigella sativa L. (Black seeds) which is a member of the Ranunculaceae family, grows in Southwestern Asia, Europe, and Northern Africa. The use of N. Sativa seeds and oil in traditional remedies goes back more than 2000 years, and the herb is described as ‘the Melanthion’ by hippocrates and dioscorides. Experimental: In the current literature review, key words including N. Sativa, thymoquinone, black seeds, toxicity, protection of hepatocellular were searched in scientific websites such as Science Direct, PubMed, Google Scholar etc. to compile the protective effects of N. Sativa against hepatocellular damage. Results: Many active components of N. Sativa have been identified, including thymoquinone, dithymoquinone, thymohydroquinone, nigellone, melanthin, nigilline, nigelamine, damascenone, p < /em>-cymene and pinene. N. Sativa is a medicinal plant with antifungal, anti-viral, anti-bacterial, anti-parasite, anti-oxidant, analgesic, antipyretic, anti-tussive, and anti-inflammatory properties. Thymoquinone could prevent many disorders such as neurobehavioral kidney and liver disorders. N. Sativa was also found to be able to relieve the symptoms of patients with several diseases, such as hypertension, dyslipidemia, metabolic syndrome, diabetes and natural and chemical toxicities. Recommended applications/industries: According to literature,N. Sativa treatment will decrease the elevated lipid peroxidation, liver enzyme levels and increase antioxidant enzyme levels. N. Sativa administration can also protect hepatic tissue from deleterious effects of toxic metals. Manuscript profile
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  2 - اثر ضد دیابت، ضد دیس لیپیدمی، محافظت کننده، و محافظتی کبدی عصاره اتانولی برگ Jatropha tanjorensis بر دیابت ناشی از آلوکسان در موش صحرایی
  چیکا اونبو اوبینا آجا چینوندو نوروم جوزفات اونووسونیه کیوما دورو اوبینا جوئل
  10.30495/medherb.2022.693310
  Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolut More

  Background & Aim: Management/ treatment of illness and maintenance of well-being using herbal medicines is the oldest and most popular form of healthcare practice known to humankind that has been practiced by all cultures in all ages throughout the history of evolution. The ethanol extract of Jatropha tanjorensis leave was evaluated for it pharmacological potency in alloxan-induced diabetes in albino rats.Experimental: Twenty-four adult male albino rats weighing 120-180g were randomly divided into six groups of four rats per group. Group I (Normal control) were given 0.2 mL of water. Group II (Negative control): were untreated diabetic rats. Group III were Diabetic rats treated with reference drug (glibenclamide at 5 mg/kg b.wt) which served as positive control. Group IV – VI were Diabetic rats treated with Jatropha tanjorensis leaf extract at a dose of 200 mg/kg b.wt, 400 mg/kg b.wt, and 600 mg/kg b.wt, respectively. Administrations were done orally for 14 days. Blood was collected from the tail of the rats to determine the blood glucose level on the 4th, 9th and 14th day of the study.Results: The extract significantly reduced the blood glucose level. The Jatropha tanjorensis leaf extract showed dose dependent significant (P<0.05) decrease in the triacylglycerol (TAG), low density lipoprotein (LDL), Cholesterol, total white blood cell (TWBC), aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, urea, creatinine level as well as significant (P<0.05) increase in hemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC) and albumin level when compared with diabetic untreated group (negative control). Diabetic-related alteration in rat serum biochemical indices were significantly improved by the extract.Recommended applications/industries: The outcome of the research gave credence to the folk use Jatropha tanjorensis leaf in the treatment of diabetes and its health related dysfunctions. Manuscript profile