Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by impaired glucose metabolism and insulin resistance. Dietary fatty acids may play a role in the progression of PCOS and related metabolic abnormalities. We conducted a case-control st More
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by impaired glucose metabolism and insulin resistance. Dietary fatty acids may play a role in the progression of PCOS and related metabolic abnormalities. We conducted a case-control study to examine the association between dietary atherogenic index (AI) and PCOS risk. The study included 203 women with PCOS and 291 healthy controls from Taleghenai Hospital in Tehran, Iran. Demographic, anthropometric, and dietary data were collected using a validated food frequency questionnaire. AI was calculated based on dietary fatty acid intake. Participants’ mean ages were 28.98±5.43 and 30.15±6.21 years for cases and controls, respectively. No significant differences in intakes of total fat, cholesterol, saturated, trans, monounsaturated fatty acids, linoleic, or linolenic acids were observed across AI quartiles (p>0.05). However, polyunsaturated fatty acid intake decreased significantly with increasing AI quartiles (p=0.034). In addition, this case-control study found no relationship between the dietary atherogenic index and the risk of PCOS among Iranian women. Further research is needed to validate these findings and elucidate the role of dietary fatty acids in PCOS pathogenesis.
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Atherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this stu More
Atherosclerosis is characterized by the accumulation of fat and inflammatory response in the artery intima and can cause narrowing or complete blockage of the artery. Thymol is a phenolic monoterpene with antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the effects of thymol on blood lipids, atherogenic indices and atheroma plaque of NMRI mice fed a high-cholesterol diet (HCD). 45 NMRI male mice were divided into 5 groups (n=9): Animals of the control group received a normal diet. Whiles in the HCD group received a diet containing 2% cholesterol for 18 weeks. Animals of the sham group received HCD for 12 weeks and then normal diet for 6 weeks with a thymol solvent (oil). The experimental groups 1 and 2 received HCD for 12 weeks and then received a normal diet with thymol at doses of 12 mg/kg and 24 mg/kg for 6 weeks, respectively. At the end of study, concentration of serum lipids and atherogenic indices were measured. Also aorta was measured microscopically. In the present study, consumption of HCD resulted in the formation of atheroma plaque, increased serum triglycerides, total cholesterol concentration, atherogenic indices and significantly decreased high density lipoprotein cholesterol (HDL-C). Treatment with both doses of thymol significantly reduced these changes and improves blood lipids, atherogenic indices was normal and atheroma plaques. The results of this study suggest that thymol can be used for treatment of increased total cholesterol and triglycerides and to improve the atheroma plaque.
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This is a study aimed to investigate the effect of lactic acid bacteria including Lactobacillus acidophilus and Sterptococcus thermophilus (as thermophilic culture), Lactococcus lactis subsp. lactis, cremoris and diacetylactis, Leuconostoc citrovorum (as mesophilic cult More
This is a study aimed to investigate the effect of lactic acid bacteria including Lactobacillus acidophilus and Sterptococcus thermophilus (as thermophilic culture), Lactococcus lactis subsp. lactis, cremoris and diacetylactis, Leuconostoc citrovorum (as mesophilic culture), Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium lactis and a mixed culture of L.acidophilus, L. casei and B. lactis on fatty acid profile, conjugated linoleic acid (CLA) and atherogenic index (AI) of butter. Fatty acid analysis with gas chromatography indicated that application of thermophilic and mixed culture decreased the ratio of saturated to unsaturated fatty acid; whereas, the butters made with L. acidophilus had the highest content of CLA. Moreover, AI in the samples prepared with thermophilic cultures was the least. Sensory evaluation of the treatments revealed no significant differences (p> 0/05) in appearance and color. However, the butters prepared with thermophilic and mesophilic cultures had more desirable taste in comparison with the samples made with L. acidophilus, L. casei and B. lactis. From the nutritional point of view, the adverse effect of butter could be diminished via the application of selected lactic acid bacteria.
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Introduction: Obesity causes high disorders as increasing atherogenic index and physical activity is able to control obesity that can possibly increase lipid peroxidation. Therefore, the study was performed to evaluate the effect of vitamin E supplementation on atheroge More
Introduction: Obesity causes high disorders as increasing atherogenic index and physical activity is able to control obesity that can possibly increase lipid peroxidation. Therefore, the study was performed to evaluate the effect of vitamin E supplementation on atherogenic and lipid peroxidation responses induced by interval training in obese male Wistar rats.Materials and methods: The present study was a laboratory experimental method. Thirty male Wistar rats were randomly selected and divided into four groups: training (TG; N=8), supplementation (SG; N=8), training with supplementation (TSG; N=8), and Control (CG; N=8). The interval training consisted of 30 minutes running on treadmill per day, 5 days a week, for 8 weeks. Vitamin E supplementation was also available daily with 300 mg/g of body weight along with drinking water in SG. Finding: The finding revealed a significant decrease between TSG compared with CG in MDA (p=0.010), AIP (p=0.001), TC (p=0.001), TG (p=0.001) and LDL-C (p=0.001) variables. Also, MDA variable a significant decrease between TSG compared with TG (p=0.001). A significant decrease between TG compared with CG and SG in AIP (p=0.031), TC (p=0.024), TG (p=0.012) and LDL-C (p=0.010) variables were observed; while HDL-C variable showed a significant increase between TSG compared with CG (p=0.024) and TG compared with CG (p=0.031) (p≤0.05).Discussion and Conclusion: Vitamin E supplementation can improve atherogenic index and by increasing of antioxidant system causes reduce exercise-induced lipid peroxidation in obese rats; while the positive effects of improving body composition and controlling obesity were achieved to exercise.
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