Coronary heart disease (CAD) is one of the most important causes of death in most countries, including Iran. Post-operative exercise coronary artery bypass grafting (CABG), and its adaptations, increase skeletal and cardiac capillary density associated to developing new More
Coronary heart disease (CAD) is one of the most important causes of death in most countries, including Iran. Post-operative exercise coronary artery bypass grafting (CABG), and its adaptations, increase skeletal and cardiac capillary density associated to developing new capillaries called angiogenesis and improve cardiovascular function and functional ability. This study aimed to investigate the effect of cardiac rehabilitation on HIF1- α gene expression in post-CABG coronary patients. The sample contained 30 men aged 45-60 years who underwent bypass surgery. They were randomly divided into experimental (n = 15) and control (n = 15) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week), and the control group did not. Blood samples were taken 48 hours before starting the first training session and 48 hours after the last training session, while all subjects were fasting. Independent and paired t-test and Shapirovilk test were used to analyze the data at a significant level of 0.05 in SPSS version 21. The results showed that the HIF-1α gene expression in the aerobic resistance group also increased in the control group which was statistically significant (p < /em> = 0.001) as well as before and after changes in the exercise group. The control group was significant (p < /em> = 0.001). Due to the findings of the present study, it can be concluded that combined (aerobic-resistance) exercises may increase cardiovascular function by increasing HIF1α-1 gene expression and the growth of new capillaries called angiogenesis and by increasing circulation. It improves patients' quality of life after CABG.
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Coronary heart disease is one of the leading causes of death in today's societies. It is associated to the exercise activity and the expression of some genes involved in the blood cholesterol transmission. Adenosine triphosphate-dependent box protein 8 is a member of AB More
Coronary heart disease is one of the leading causes of death in today's societies. It is associated to the exercise activity and the expression of some genes involved in the blood cholesterol transmission. Adenosine triphosphate-dependent box protein 8 is a member of ABC transporter family which plays a key role in the metabolism of high-density lipoprotein cholesterol and cholesterol. This study aimed to evaluate the effect of eight weeks of aerobic resistance training on ABCG8 gene expression and lipid profile in CABG patients. 30 men with CABG patients voluntarily selected and randomly divided into the experimental (n = 15) and control (n = 15) groups. The experimental group performed the aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 48 h before the first training session and 48 h after the last training session, while all subjects were fasting. Independent and paired t-test used to analyze the data at a significant level of 0.05. The present study's results showed that the aerobic resistance training group showed a significant increase in the ABCG8 mRNA expression and a significant decrease in LDL-C, triglyceride, and HDL-C as compared to the control group. Due to the findings of present study, it can be concluded that aerobic resistance training by increasing ABCG8 gene expression has a great effect on increasing the cholesterol transfer process; thus, it may improve the CABG patients and prevent cardiovascular diseases.
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Cardiovascular diseases are one of the leading causes of death in the world. According to the American Heart Association, the prevalence of the cardiovascular diseases has an inflammatory basis, and general inflammation plays a central role in the development of atheros More
Cardiovascular diseases are one of the leading causes of death in the world. According to the American Heart Association, the prevalence of the cardiovascular diseases has an inflammatory basis, and general inflammation plays a central role in the development of atherosclerosis. The purpose of this study was to investigate the effect of eight weeks of aerobic resistance training on LXR gene expression and serum TNFα levels in CABG patients. Twenty-four men who underwent bypass surgery were voluntarily selected and randomly divided into experimental (n=12) and control (n=12) groups. The experimental group performed aerobic resistance training for eight weeks (3 sessions per week) and the control group did not. Blood samples were taken 48 hours before the start of the first training session and also 48 hours after the last training session while all subjects fated. Independent and paired samples Student's t-test and Shapirovilk test were used to normalize the data at a significant level of 0.05. The results of the present study showed that the training group experienced a significant increase in LXR mRNA gene expression and a decrease in serum TNFα levels as a result of eight weeks of aerobic resistance training compared to the control group. The same changes were seen as the within group differences in the pre-test and post-test in the training group. The findings of this study showed that an eight-week combined aerobic and resistance training program could regularly increase the LXR gene expression and decrease serum TNFα levels in CABG patients
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