List of Articles هموسیستئین

• Open Access Article
  • Abstract Page
  • Full-Text
  
  1 - The effect of TRX training on nitric oxide and homocysteine levels as indicators of vascular endothelial and inflammation in inactive obese women
  shima Ghardashkgani gerde Abdolali Banaeifar saeid sedaghati yaser kazemzadeh keyvan molanorouzi
  Introduction & Objective:  Recent studies suggest that obesity plays an effective role in the occurrence of inflammation; on the other hand, inflammation can affect on function of vascular endothelium. High levels of homocysteine ​​can lead to inflammation and More

  Introduction & Objective:  Recent studies suggest that obesity plays an effective role in the occurrence of inflammation; on the other hand, inflammation can affect on function of vascular endothelium. High levels of homocysteine ​​can lead to inflammation and vascular endothelium damage. Nitric oxide is also considered as one of the influencing factors on endothelial function. The present study was conducted with the aim of determining the effect of 8 weeks of TRX training on the levels of homocysteine ​​(Hcy) and nitric oxide (NO) in inactive obese women. Material and Methods: In this quasi-experimental study, 28 obese women with a mean age of 44.34 ±0.82 years were randomly divided into TRX (n = 16) and control (n = 16) groups. The experimental group program consisted of TRX training for eight weeks and three days a week for 50-60 minutes. Serum levels of homocysteine, nitric oxide were measured before and 48 hours after the last training session. Independent and dependent t-tests were used to examine the differences between groups and within-group changes. Result:After eight weeks of TRX training, comparison results within and between groups are displayed that the mean homocysteine index in the exercise group decreased significantly compared to the control group (p = 0.01). Also, exercise led to an increase in nitric oxide levels in obese women, although this increase was not statistically significant. Conclusion: Based on the findings of the research, it seems that doing TRX training can be effective as an exercise method in reducing inflammation and improving endothelial function in obese women. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  2 - Evaluation of serum homocysteine and cardiac troponin I in sheep with theileriosis in Urmia city
  Kaveh Azimzadeh Asghar Hasanpour
  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep More

  Theileriosis is an important protozoal disease of domestic animals with a substantial role in reduction of production (milk and meat). The aim of the present study was to evaluate serum homocysteine and cardiac troponin I as biomarkers of cardiovascular damage in sheep affected by theileriosis based on gender and breed in Urmia city. After diagnosis of theileriosis based on clinical and laboratory symptoms, 30 infected sheep were selected (15 Ghezel breed and 15 Makouei breed) with 8 males and 7 females from each breed. Meanwhile, the same number of healthy sheep (based on sex and breed) were selected as healthy group. Thereafter, blood samples were taken from the jugular vein in both groups and the previously mentioned parameters were measured and evaluated statistically. The results showed a significant increase (p≤0.05) in all parameters in diseased sheep in comparison to healthy ones. In terms of gender, significant increase in all parameters were observed in males compared with females and in the case of breed, there was a significant difference between the Makouei breed with healthy sheep and Ghezel with healthy ones (p≤ 0.05). Overall, it can be concluded that increase of serum homocysteine and cardiac troponin I in sheep with theileriosis, especially in males, could be a warning that careful attention should be paid to the prevention and treatment of sheep with theileriosis. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  3 - The effects of dietary folic acid and methionine administration on yolk and serum 5-methyltetrahydrofolate and zinc content and quantity of homocysteine on the laying hens serum
  ستار Bagheri حسین Janmohammadi رامین Maleki a.r Ostadrahimi روح الله Kianfar
  This study was performed to evaluate   the effects of folic acid (FA) and methionine (Mt) administration on egg 5-methyltetrahydrofolate (5-MTHF) content, levels of zinc in yolk and serum and concentration of homocysteine on Hy-line W36 hens from 20 to 26 week More

  This study was performed to evaluate   the effects of folic acid (FA) and methionine (Mt) administration on egg 5-methyltetrahydrofolate (5-MTHF) content, levels of zinc in yolk and serum and concentration of homocysteine on Hy-line W36 hens from 20 to 26 weeks of age. The experiment was conducted as a 4×4 factorial arrangement of treatments in randomized complete design with four levels of Mt (0.25, 0.32, 042, 0.48 mg/kg of diet) and four levels of FA (0, 5, 10, 15 mg/kg of diet). Fortification of laying hens diets with FA 0, 5, 10 and15 mg/kg of diet increased 5-MTHF into yolk significantly (p<0.05). 5-MTHF content of egg was also significantly affected by FA×Mt interaction (p<0.05). FA significantly reduced Zn level of egg and serum (p<0.05), but Mt did not have any effect on Zn content in egg. Levels of serum homocysteine were significantly reduced by fortification of diet by FA (p<0.05).Supplementation of laying poultry diet with FA and Mt could improve the content of yolk 5-MTHF. Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  4 - Evaluation of plasma homocysteine status in streptozotocin induced-diabetes mellitus in rabbit
  کاوه Azimzadeh سیامک Asri rezae Sh Safi ایرج Sohrabi haghdoust مجید Ebrahimi hamed
  In this research, plasma homocysteine levels as an independent risk factor of cardiovascular disease was evaluated in streptozotocin induced diabetic New Zealand white rabbits. Twelve male New Zealand white rabbits were selected and allocated into two separate groups of More

  In this research, plasma homocysteine levels as an independent risk factor of cardiovascular disease was evaluated in streptozotocin induced diabetic New Zealand white rabbits. Twelve male New Zealand white rabbits were selected and allocated into two separate groups of test and control. Following confirmation of the rabbit’s health status (normal plasma glucose, urea and creatinine values), those in the test group received a single dose of streptozotocin at 65 mg/kg through the marginal ear vein while the control group were given normal saline solution. Blood samples were collected from the marginal ear vein after 24, 48 and 72 hours and then once every week for 12 weeks and plasma homocysteine, insulin and glucose levels were measured and statistically evaluated. The results indicated significant increase (p<0.01) of plasma homocysteine and glucose levels and significant decrease (p<0.01) of plasma insulin levels of the treatment group in comparison with the control group throughout the 12 week study period. In the present study, despite the decrease in plasma insulin level, increase of plasma homocysteine was observed as an independent risk factor of cardiovascular disease in New Zealand white rabbits.   Manuscript profile
• Open Access Article
  • Abstract Page
  • Full-Text
  
  5 - تأثیر مصرف مکمل بتائین در آخر دوره آبستنی بر غلظت متابولیت های خونی، هموسیستئین و پراکسیداسیون لیپیدی در میش های آبستن و نتاج آن‌ها
  ح.ر. صحرائی ع. کیانی آ. آذرفر ح. خمیس آبادی
  بتائین (تری ­متیل گلیسین) یک ترکیب دهنده گروه متیل است که در بسیاری از فرایندهای مهم فیزیولوژیک از قبیل سنتز هموسیستئین، کاهش استرس اکسیداتیو و کاهش پراکسیداسیون چربی نقش دارد. در مطالعه حاضر، اثر افزودن بتائین بر غلظت خونی بتاهیدروکسی بوتیرات، هموسیستئین، گلوتاتیون More

  بتائین (تری ­متیل گلیسین) یک ترکیب دهنده گروه متیل است که در بسیاری از فرایندهای مهم فیزیولوژیک از قبیل سنتز هموسیستئین، کاهش استرس اکسیداتیو و کاهش پراکسیداسیون چربی نقش دارد. در مطالعه حاضر، اثر افزودن بتائین بر غلظت خونی بتاهیدروکسی بوتیرات، هموسیستئین، گلوتاتیون پراکسیداز، کاتالاز و مالون دی آلدئید و غلظت گلوکز، اوره و پروتئین کل سرم خون در میش‌های آبستن بررسی شد. علاوه بر این اثر افزودن پیش از زایش بتائین بر غلظت گلوکز، اوره و انسولین سرم خون بره­ ها مطالعه شد. در طول ماه آخر آبستنی 20 رأس میش چند شکم زایش سنجابی با جیره پایه (شاهد: 3.6±71.2 کیلوگرم) و یا جیره پایه به علاوه 5 گرم بتائین به ازای هر رأس در روز (بتائین: 3.8±71.6 کیلوگرم) تغذیه شد. نمونه خون از میش‌ها در روز زایش و از بره‌ها در روز تولد، 14 و 28 روزگی گرفته شد. میش‌های گروه بتائین مقادیر کمتری از بتاهیدروکسی بوتیرات (0.18±0.55 در مقابل 0.37±1.88 میلی­مول در لیتر) و مالونیل آلدئید (0.51±8.1 در مقابل 0.61±9.1 میکرومول در لیتر) را نسبت به میش‌های گروه شاهد داشتند، اما غلظت خونی هموسیستئین، آنزیم‌های آنتی‌اکسیدانی، گلوکز، اوره و پروتئین کل تفاوتی نداشت. بره‌های گروه بتائین وزن تولد بیشتری را نسبت به بره‌های گروه شاهد داشتند (0.18±4.41 در مقابل 0.18±3.95 کیلوگرم؛ P=0.06). بره‌های هر دو گروه عملکرد رشد یکسانی را تا 60 روزگی داشتند. افزودن بتائین در ماه آخر آبستنی تأثیری بر غظت خونی گلوکز، انسولین و اوره بره‌ها نداشت. نتیجه کلی اینکه، افزودن بتائین به جیره میش‌های آبستن سبب کاهش غلظت خونی بتاهیدروکسی بوتیرات احتمالا از طریق کاهش اکسیداسیون چربی شد و منجر به وزن تولد سنگین‌تر بره‌ها شد. Manuscript profile