List of Articles نارینژنین

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  1 - A study of the effect of Naringinin derived amyloid and animal curvature and applied with 6-hydroxydopamine dermatosis in Parkinson's disease
  BAHAR haghani Maryam khosravi jalal solati ramin haji
  Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta More

  Materials and Methods: In this study, the NMRI adult male mice were anesthetized. To induce the Parkinson's animal model, a 22 gauge cannula was placed into the left Substantia Nigra pars compacta and then 6-hydroxydopamine was infused to Substantia Nigra pars compacta through a 30-gauge cannula. The group control1 received saline on the left side of the Substantia Nigra pars compacta.Then, to investigate the effect of the Naringenin, group control2 received distilled water and other groups received Naringenin via gavage for two weeks, and apomorphine induced rotation, catalepsy, and behavioral tests were assessed in all groups. Hematoxylin and eosin staining was performed and the percentage of the neurons on the left side of the Substantia Nigra pars compacta were calculated. In this study, in cell culture model, dopaminergic-like neurons cultured in DMEM medium were counted, and cells were used and incubated to evaluate the effect of naringinin against 6-hydroxy dopamine. Concentrations were 50 for 6-hydroxy dopamine solution and 0.25, 0.1 and 0.01 for NAR solution. Finally, cell viability was assessed using MTT and trypan blue methods.Results: 6-Hydroxy dopamine increased catalepsy and contralateral turns compared to the control group. Naringin reduced catalapsy and contralateral turns, it reduced anxiety and depressive-like behaviours besides that it increased swimming time and locomotor activity compared to the control group. Conclusion: it seems that Naringin is a therapeutic option for neurodegenerative disorders, such as Parkinson's disease. Manuscript profile
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  2 - protective effect of Naringenin (Citrus flavonone) on incipient diabetic nephropathy in the rats with alloxan-induced diabetes
  Yousef Doustar رامین Kaffash Elahi داریوش Mohajeri
  Diabetes mellitus is a metabolic abnormality that has a relatively high prevalence all over the world. Kidney failure is one of the main complications of diabetes. Many therapeutic methods have been introduced from all over the world to treat diabetes. The aim of the pr More

  Diabetes mellitus is a metabolic abnormality that has a relatively high prevalence all over the world. Kidney failure is one of the main complications of diabetes. Many therapeutic methods have been introduced from all over the world to treat diabetes. The aim of the present study was to assess the protective effect of Naringenin on early kidney injuries in alloxan-induced diabetic rats. Forty male Wistar rats were randomly allocated into 4 equal groups, including: healthy control, normal healthy receiving Naringenin, diabetic and diabetic receiving Naringenin. Diabetes was also induced by intraperitoneal injection of a single dose of naloxone (120 mg/kg). Naringenin treatment groups received the drug (50 mg/kg) daily for 3 weeks through the gavage. Finally, serum levels of kidney function markers including urea, uric acid and creatinine as well as amount of lipid peroxidation product (MDA) and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were assessed in kidney hemogenates. Moreover, histopathological observation was assayed at the degree of renal injury. Significant differences among the groups were determined by one-way analysis of variance followed by Tukey post-test. Statistical significance was considered at p<0.05. In alloxanized diabetic rats, Naringenin significantly decreased the levels of serum urea, uric acid and creatinine (p<0.05), and significantly decreased the lipid peroxidation and elevated the levels of antioxidant enzymes in these rats (p<0.05). Histopathological changes were in agreement with biochemical findings. The results of the present study showed that naringenin with antioxidant properties can prevent early diabetic kidney damage. Manuscript profile
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  3 - Study on protective effect of Naringenin (Citrus flavonone) on incipient diabetic hepatopathy in alloxan-induced diabetic rats
  daryoush mohajeri ghafour mousavi ramin kaffashielahi mehrdad neshatgharamaleki
  Abstract    Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. Hepatic insufficiency is one of the most important consequences in this disease. A multitude of drugs has been described for the treatment of More

  Abstract    Diabetes mellitus is a metabolic disorder and its incidence is considered to be high all over the world. Hepatic insufficiency is one of the most important consequences in this disease. A multitude of drugs has been described for the treatment of diabetes throughout the world. The aim of the present study was to assess the protective effect of Naringenin on early liver injury in alloxan-induced diabetic rats. Forty male Wistar rats were randomly assigned into 4 different groups of 10 rats each, including healthy control rats, normal healthy rats receiving Naringenin (50 mg/kg), diabetic rats and diabetic rats receiving Naringenin (50 mg/kg). Diabetes was induced with a single injection of alloxan (120 mg/kg i.p.). Naringenin groups received the drug daily for 3 weeks through gavage. At the end of the experiment, levels of liver function marker enzymes AST (Aspartate aminotransferase), ALT (Alanine aminotransferase) and ALP (Alkaline Phosphatase), TB (Total Bilirubin), Alb (Albumin) and TP (Total Proteins) were assessed in serum. Product of lipid peroxidation (Malondialdehyde; MDA), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were also assayed in liver homogenate to evaluate antioxidant activity. Moreover, histopathological observations were made to assess the degree of hepatic injury. In alloxanized diabetic rats, Naringenin significantly decreased the levels of serum biomarkers of hepatic injury and TB, and elevated the levels of Alb and TP. Furthermore, Naringenin significantly decreased the lipid peroxidation and elevated the levels of antioxidant enzymes in these rats. Histopathological changes were in agreement with biochemical findings. The findings of this study indicated that Naringenin due to its antioxidant activities protects rats liver from early diabetic hepatopathy. Manuscript profile
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  4 - Preventive effects of Naringenin (Citrus flavonone) on intestinal ischemia–reperfusion injury in the rat
  ghafour mousavi
  The intestinal mucosa is known to be adversely affected by ischemia-reperfusion (I/R). It has been demonstrated that Naringenin has protective effects against ischemia-reperfusion injury in various organs. The aim of this study is to determine whether Naringenin has any More

  The intestinal mucosa is known to be adversely affected by ischemia-reperfusion (I/R). It has been demonstrated that Naringenin has protective effects against ischemia-reperfusion injury in various organs. The aim of this study is to determine whether Naringenin has any protective role in I/R injury of the intestine in rats. For this purpose, forty male Wistar rats were randomly divided into four groups as control (group 1), sham IR (group 2), intestinal IR group (group 3) and Naringenin plus intestinal IR (group 4). Intestinal IR was produced by 30 minutes of intestinal ischemia followed by a 60 minutes of reperfusion. Rats in group 4 received Naringenin (20 mg/kg) intraperitoneally, 120 minutes before ischemia. After the experiments, the jejunum was removed and the tissues were processed for histopathological examination. Serum total antioxidant activity (TAA), and levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were measured in jejunal tissue. Histopathologically, jejunal tissues of the intestinal IR group showed severe inflammatory cell infiltration, villus shortening and blunting and hemorrhage in lamina propria, as well as epithelial cell necrosis. Administration of Naringenin alleviated the jejunal damage in group 4. Levels of TAA, SOD, CAT, GPx and GR decreased in the intestinal IR group, but increased significantly (p<0.05) in the IR+Naringenin group. Naringenin significantly (p<0.05) decreased MDA levels which was increased by IR. Our results showed that Naringenin treatment protected the rat's intestinal tissue against intestinal ischemia-reperfusion injury. Manuscript profile