List of Articles متفورمین

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  1 - Study of potential Ricinus communis in Absorption of Metformin Hydrochloride
  Sepideh Hosseini Roxana Moogouei Mehdi Borghei Golnaz Tjadod
  10.22034/jest.2017.10716
  Background and Objective: This study has considered for potential plant species Ricinus communis of remediation metformin hydrochloride drug. Method: In phytoremediation method for remediation of metformin hydrochloride solution, the first Ricinus communis has been cult More

  Background and Objective: This study has considered for potential plant species Ricinus communis of remediation metformin hydrochloride drug. Method: In phytoremediation method for remediation of metformin hydrochloride solution, the first Ricinus communis has been cultured in the soil and then metformin absorption of solution has been kept with 20 ppm and 50 ppm in control and laboratory situation, for 14 days. Finally the solution has been injected to HPLC device to detected of remind metformin hydrochloride drug. Findings: the end of 14 days has been recognized Ricinus communis has %45.06 and 21 % efficiency in two different 20 ppm and 50 ppm. Discussion and Conclusion: This study has been shown that the maximum %45.06 has been remediated from metformin hydrochloride solution that related to minimum (20 ppm) of metformin solution. The result has been shown that Ricinus communis can be middle species for remediation of metformin hydrochloride drug from metformin hydrochloride solution. Manuscript profile
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  2 - Preventive effects of metformin on renal ischemia-reperfusion injury in the rat
  ahmad asghari ghazal kashfiyeganeh pejman mortazavi
     Renal ischemia causes oxidative stress which leads to severe and prolonged inflammatory responses following reperfusion. Re-perfusion injury in the kidney is a causal factor of acute renal failure which has been studied in different animals and clinical mod More

     Renal ischemia causes oxidative stress which leads to severe and prolonged inflammatory responses following reperfusion. Re-perfusion injury in the kidney is a causal factor of acute renal failure which has been studied in different animals and clinical models. Metformin is an oral medication used alone or with other medications to treat type 2 diabetes. The purpose of this study was to evaluate the effect of metformin following the induction of ischemia-reperfusion in the rat kidney. In this study, 30 adult male Wistar rats weighing 200-250g were used which were divided randomly into three groups of 10 which include the sham group; this  group had not received any medication and after only a week, the abdominal cavity was opened then left renal nephrectomy was performed and the abdominal cavity reclosed. The control group (IR): this group had not received any medication until induction of ischemia-reperfusion and after a week the abdominal cavity was opened and following ischemia- reperfusion, left kidney nephrectomy was performed. I/R+MET group: this group was gavaged with a dose of metformin (100 mg/kg) each day for a week at a same time and after a week the abdominal cavity was opened and then ischemia-reperfusion was induced and left kidney nephrectomy performed. In all groups except sham, both the renal pedicles were closed and released after 45 minutes for induction of ischemia-reperfusion. After 4 and 8 hours, left kidney nephrectomy was performed. At day zero (before drug administration) and after the end of ischemia-reperfusion and during renal nephrectomy, blood samples were collected and serum creatinine and BUN levels were examined. The data obtained analyzed by ANOVA on significant levels (p<0.05). Histopathological results of I/R+MET group showed degeneration and cell swelling in some tubules at low levels and mild pyknosis and the nucleus and cytoplasm of most tubules were normal. The serological results obtained indicated a slight and insignificant decrease in BUN and serum creatinine in I/R+MET group compared with the I/R group. This study showed that metformin relatively protects the kidney from ischemia-reperfusion injury.   Manuscript profile
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  3 - Assessment of Liver Histopathology in Female Rats with Diabetes and Metabolic Syndrome and Its Therapeutic Methods with the Aim to Reduce Injury
  Mahnaz Nouri Behrooz Yahyaei Sahar Yazdi
  Metabolic syndrome is one of the most common metabolic disorders that put a person at many risks, such as cardiovascular diseases and diabetes. Moreover, the increasing prevalence of type 2 diabetes, especially in younger people has led to an increase in its incidence i More

  Metabolic syndrome is one of the most common metabolic disorders that put a person at many risks, such as cardiovascular diseases and diabetes. Moreover, the increasing prevalence of type 2 diabetes, especially in younger people has led to an increase in its incidence in pregnancy. Diabetes mellitus is one of the risk factors for labor, and the incidence of major malformation is twice as high as in women with diabetes. Therefore, the aim of this study was to investigate the histopathological changes of the liver in mothers with diabetes and metabolic syndrome and to review the existing therapeutic methods.  This study was conducted on 34 wistar rats. Animals were divided into nine groups. Female rats were prepared for sampling and microscopic studies after the pregnancy period was passed. In diabetic groups, the effects of diabetes were reduced only by taking metformin, and exercise had no effect on healing the liver tissue, while in the group of metabolic syndrome, exercise could reduce the effects of syndrome and this result was more effective than metformin and the combination of metformin and exercise also had significant rehabilitation effects on liver. In some variables, such as hyperemia and inflammation, these effects were observed less than those who only exercised. In metabolic syndrome group, who exercised, no hyperemia and inflammation was observed, while in metabolic syndrome group under metformin treatment and exercise, inflammation and congestion were observed. The results show the combination of metformin, and sports exercise can reduce changes caused by metabolic syndrome and probably diabetes. Manuscript profile
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  4 - Therapeutic Effect of Metformin on Necrotic Cell Death of Hippocampal Cells and Improvement of Spatial Memory in the Fetal Rat of Model Alcohol Spectrum Disorders
  Maryam Sabzali Akram Eidi Mahdi Khaksari Hossin Khastar
  10.22034/ascij.2022.1933390.1264
  Exposure to alcohol during pregnancy causes a wide range of long-term physiological and behavioral effects, collectively referred to as fetal alcohol syndrome (FASD). Nervous disorders due to alcohol abuse in children with apoptosis in several areas of the brain such as More

  Exposure to alcohol during pregnancy causes a wide range of long-term physiological and behavioral effects, collectively referred to as fetal alcohol syndrome (FASD). Nervous disorders due to alcohol abuse in children with apoptosis in several areas of the brain such as the hippocampus is associated with activation of the oxidative-inflammatory cascade and high levels of nerve degeneration. Studies have shown that metformin (1,1-dimethyl hydrochloride), used as a first-line drug for the treatment of type 2 diabetes, can rapidly cross the blood-brain barrier (BBB) ​​and have neuroprotective effects in several diseases of the nervous system. The aim of this study was to assess the protective activities of metformin on memory impairment and neuronal necrosis in the rat hippocampus by postnatal alcohol exposure received by gavage on days 2-10 after birth. Moreover, infants received 20 and 40 mg/kg of metformin on days 2-10 after birth. To assess spatial memory, the Morris water maze test was performed 36 days after birth. After the behavioral test, nickel staining was performed to assess necrotic cells. The results revealed that metformin treatment could significantly improve spatial memory impairment (P <0.01) and significantly reduced necrotic neurons in the metformin treatment group compared to the ethanol group (P <0.01). Metformin has been shown to improve spatial memory impairment in neonatal rats exposed to ethanol and significantly prevent necrotic death of hippocampal neurons. Manuscript profile