List of Articles مارکرهای قلبی

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  1 - Study of cardiovascular biomarkers, cystatin-C and adenosine deaminase in alloxan-induced diabetes mellitus in the dog
  کاوه Azimzadeh
  Diabetes mellitus (DM) is a metabolic disease which may lead to considerable damages in most tissues. The purpose of this study was to assess whether the levels of serum Cardiac troponin I (cTnI), Homocysteine (Hcy), Cystatin c (Cys-C) and adenosine deaminase (ADA) acti More

  Diabetes mellitus (DM) is a metabolic disease which may lead to considerable damages in most tissues. The purpose of this study was to assess whether the levels of serum Cardiac troponin I (cTnI), Homocysteine (Hcy), Cystatin c (Cys-C) and adenosine deaminase (ADA) activity are altered in alloxan induced diabetes mellitus in the dog. In this study, DM was induced by alloxan in the treatment group and three months later, plasma cTnI, Hcy and Cys-C were evaluated by Elisa technique and ADA activity was assessed by Electrochemilumminescence (ECL) method. The results showed significant increases (p<0.01) in cTnI and Cys-C along with a considerable decrease in ADA in the treatment group in comparison to the intact healthy group. Conclusively, increased plasma levels of cTnI and Cys-C in dogs with DM indicates heart and kidney damage respectively, which requires effective measures in the management of diabetes mellitus in dogs. Furthermore, reduction of ADA activity can be attributed to the decline of immune system (especially T cells), high levels of adenosine concentrations for facilitation of glucose transport and/or zinc ion decrease. Manuscript profile
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  2 - Evaluation of cardiac markers and some serumic biochemical parameters in seropositive horses with equine influenza
  ali hassanpour bahram amouoghlitabrizi mansour khakpour
  Abstract          This study was performed to evaluate the effect of influenza in horses on the electrocardiogram changes, cardiac arrhythmias and concentration of cardiac troponin in serum and serumic activity of some enzymes. More

  Abstract          This study was performed to evaluate the effect of influenza in horses on the electrocardiogram changes, cardiac arrhythmias and concentration of cardiac troponin in serum and serumic activity of some enzymes. After electrocardiography and count heart rate, blood samples were taken from jugular vein in 202 stallions (1-3 years). After centrifugation, the serum was removed and then seroprevalence of equine influenza was investigated by ELISA method. From 202 horses, 19 samples (9.5%) were positive and 183 samples (90.5%) were negative and these horses were put in deseased and healthy groups, respectively. In all samples cardiac troponin I, liver enzymes, total protein, albumin, glucose, urea, creatinin, cholesterol and triglyceride in the serum were measured. The electrocardiograms of all the horses were taken and the kind of cardiac arrhythmias were recorded. Average heart rate increased significantly in diseased group (p< 0.05). Occurrence of cardiac arrhythmias was significantly greater in diseased group (p< 0.05). Changes in QRS complex were significant in diseased group. The serumic concentration of cardiac troponin I increased significantly (p= 0.023). The difference mean of liver enzymes was not significant between two groups exept for alkaline phosphatase. In diseased group the mean of total protein and albumin increased significantly (p= 0.046 and p= 0.021, respectively) but, glucose and cholesterol decreased nonsignificantly. The mean difference of urea, creatinin and triglyceride was nonsignificant between the two groups. The end result was that following equine influenza some electrocardiographic changes were created in horses most of which are physiologic changes and the concentration of cardiac troponin I, total protein, albumin and liver enzymes in are increased.  Manuscript profile