Disturbance in wound healing process is considered to be one of the most serious complications of diabetes, because it significantly increases the susceptibility of patient wounds to be infected. Fenugreek is an annual plant which its leaves and seeds used extensively i More
Disturbance in wound healing process is considered to be one of the most serious complications of diabetes, because it significantly increases the susceptibility of patient wounds to be infected. Fenugreek is an annual plant which its leaves and seeds used extensively in foods and has advantages to human health. Due to prevalence rate and side effects of diabetes, Fenugreek seed extract is one of medicinal herb have been used more frequently. The present study was performed to investigate the effects of using fenugreek seed hydroethanolic extract on wound healing process in the 54 mice model of diabetes type 2. One single full-thickness excisional wound was created with 6-mm punch biopsy on back of each mice. All animal, accidentally, divided in three groups: Control group, 10% and 5% fenugreek seed hydroethanolic extract treatment groups. In terms of microscopic, the rate of tissue edema, neo-vascularization, fibroblast infiltration, collagen deposition and re- epithelialization were evaluated. Results revealed that the edema score significantly decreased (P<0.05) in both treatment groups compared to the control group, whereas the neo-vascularization, fibroblast infiltration, collagen deposition and re- epithelialization significantly increased (P<0.05) in both treatment groups compared to the control group. These results showed that topical administration of fenugreek seed hydroethanolic extract promote skin full-thickness excision wound healing process in diabetic animal model.
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Pato physiological process of wound healing involves the interaction of cellular and biochemical processes. According to Ash anti-inflammatory effect Fraxinus extract the aim of this study was to evaluate the effect of Fraxinus extract ointment incisional wound healing More
Pato physiological process of wound healing involves the interaction of cellular and biochemical processes. According to Ash anti-inflammatory effect Fraxinus extract the aim of this study was to evaluate the effect of Fraxinus extract ointment incisional wound healing in rats can be. Method: Ash fruits and leafy branches after identification by the university herbarium, extract by Soxhlet extraction using rotary powder was prepared.Then ointment 70% and 35% as a percentage of the volume using eucerin (ointment base) and the dried extract was created.To induce colitis in male Wistar rats first (g200 ± 230) were anesthetized with ether and In the middle of incisional wound to the back of the animals during 2 (cm) and the thickness of the dermis was created. Rats in four groups (n = 8), no treatment (negative control), eucerin treatment (positive control), treated with ointment were 35% and 70% Fraxinus extract .Treatment every other day for . 14 days was done Before treatment, the wound was photographed by a digital camera and then with the help of AutoCAD software and the percentage of wound healing, wound surface area was determined.Data analyzed by SPSS software and ANOVA and Tukey test were analyzed.The results showed ointment 35% and 70% Ash significant increase in the percentage of wound healing compared to the control group were positive.Result :Fraxinus extract extract is accelerated wound healing in rats.
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The aim of the current study was to evaluate of wound healing activity of flaxseed oil and its combination with Cinnamon hydroalcoholic extract on excision of wound healing model in rabbit. Sixty New Zealand white rabbits were randomly allocated into 4 experimental grou More
The aim of the current study was to evaluate of wound healing activity of flaxseed oil and its combination with Cinnamon hydroalcoholic extract on excision of wound healing model in rabbit. Sixty New Zealand white rabbits were randomly allocated into 4 experimental groups. Two full-thickness skin excisional wounds were created on thoracolumbar region on each side of the dorsal midline in each rabbit. Rabbits in group 1 did not receive any treatments. In group 2, rabbits received placebo ointment; in group 3, animals were treated with flaxseed oil 2% ointment. In group 4, rabbits received ointment containing a combination of flaxseed 2%+Cinnamon hydroalcoholic extract 3%. Wound area (mm2) was determined on days 4, 8, 12, 16 and 20 using a transparent paper. Tissue samples were collected on days 3, 7, 14 and 20 for histopathological studies with Masson trichrome staining.
According to the results, ointment containing a combination of flaxseed oil 2%+Cinnamon hydroalcoholic extract 3% significantly decreased wound area on all days after wounding in comporison with the control (p<0.05). Also, this combination ointment caused a significantly improved fibroblast distribution in treated animals compared to other groups (p<0.05). Our data showed that co-administration of flaxseed oil 2%+Cinnamon hydroalcoholic extract 3% ointment had beneficial effects on wound healing.
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دیابت، یکی از بیماری های غده ای در جهان است و التیام زخم را به تأخیر می اندازد. شنبلیله، دارای اثرات دارویی است. بنابراین این مطالعه با هدف بررسی کارایی تجویز خوراکی عصاره آبی بذر شنبلیله بر التیام زخم باز در مدل حیوانی آزمایشی دیابت انجام شد. استرپتوزوتوسین برای القای More
دیابت، یکی از بیماری های غده ای در جهان است و التیام زخم را به تأخیر می اندازد. شنبلیله، دارای اثرات دارویی است. بنابراین این مطالعه با هدف بررسی کارایی تجویز خوراکی عصاره آبی بذر شنبلیله بر التیام زخم باز در مدل حیوانی آزمایشی دیابت انجام شد. استرپتوزوتوسین برای القای دیابت تجویز شد. یک زخم برشی با اندازه 6 میلیمتر روی ناحیه پشتی 24 موش صحرایی ایجاد شد. حیوانات به 4 گروه غیردیابتی، کنترل دیابتی و دیابتی تجویز خوراکی شده با 200 و 400 میلی گرم/کیلوگرم از عصاره شنبلیله تقسیم شدند. اندازه ناحیه زخم، پارامترهای بافت شناسی و غلظت سرمی انسولین و گلوکز خون در روزهای 3، 7 و 16 بررسی شدند. نتایج این مطالعه نشان داد که تجویز عصاره آبی بذر شنبلیله بطور معنی داری ناحیه زخم و غلظت گلوکز را در مقایسه با گروه کنترل از روز 7 کاهش داد (0/05>P). در مجموع، تجویز خوراکی عصاره آبی بذر شنبلیله قند خون را کاهش داده و باعث بهبود التیام زخم در موش های صحرایی دیابتی شد.
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