List of Articles رازک

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  1 - Investigation of the Effect of Hop (Hyssoupus officinalis L.) and Hyssop (Humulus lupulus L.) Ethanolic Extracts on the Prevention of Staphylococcus aureus Growth in Doogh
  Z. Ghaleh Mosiyani R. Pourahmad P. Rajaei
  Introduction: Nowadays with regard to the harmful effects of synthetic preservatives onconsumers' health, the use of natural antimicrobial compounds such as herbal extracts in foodpreservation is considerably increasing. Doogh or drinking yogurt is a kind of dairy drink More

  Introduction: Nowadays with regard to the harmful effects of synthetic preservatives onconsumers' health, the use of natural antimicrobial compounds such as herbal extracts in foodpreservation is considerably increasing. Doogh or drinking yogurt is a kind of dairy drinkmade of yoghurt and water which is highly favored in Iran. Staphylococcus aureus is abacterium causing toxicity in dairy products. The purpose of this study is to investigate theeffect of hop and hyssop ethanolic extracts on the prevention of Staphylococcus aureusgrowth in doogh.Materials and Methods: Minimum Inhibitory Concentration (MIC) and MinimumBactericidal Concentration (MBC) of hop and hyssop ethanolic extracts were calculated.Moreover, the antibacterial activity of those extracts was examined using diffusion diskmethod, and chemical and sensory properties of doogh were also tested on the 1st, 7th, and 14thdays.Results: MIC of hop and hyssop extracts were respectively 12.5 mg/mL and 6.25 mg/mL,whereas MBC of those extracts were respectively 25 mg/mL and 12.5 mg/mL. By addingherbal extracts, acidity of the samples decreased and pH increased (p<0.05). Moreover, byadding herbal extracts, the scores of sensory properties of the samples decreased (p<0.05).Among the samples containing herbal extracts, sample containing 12.5 mg/mL hyssop extracthad the best sensory quality.Conclusion: Hop and hyssop extracts had antimicrobial activity against Staphylococcusaureus and they can be used as natural preservatives in doogh. Among doogh samples,sample containing 12.5 mg/mL hyssop extract can be selected as the best sample regarding itssuitable antimicrobial activity and sensory quality. Manuscript profile
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  2 - The Effect Of Ethanol Extracts Of Hops on Sexual Hormone Levels and Ovarian Follicles Numbers in Syrian Adult Mice
  سید ابراهیم حسینی مهرداد شریعتی هادی توکلی
  Inroduction and ObjectiveThe use of chemical drugs to treat disease associated with usually side effects. In recent years the use of herbal medicines, which have far fewer side effects, in the treatment of various diseases, including infertility has increased. Therefore More

  Inroduction and ObjectiveThe use of chemical drugs to treat disease associated with usually side effects. In recent years the use of herbal medicines, which have far fewer side effects, in the treatment of various diseases, including infertility has increased. Therefore, this study aimed to evaluate the effect of hops flower extract on adult female sexual hormones and sexual dynastic cells.Materials and Methods:The experimental study was conducted on 40 adult female mice . The mice were divided into 5 groups of 8 including control groups (no treatment), the control (saline) and three experimental groups receiving doses of hops flower extract 50,100 and 150 mg /kg, respectively. All the prescription was done in gavage and in 21 days. At the end of the experiments, phlebotomizing the hearts of the animals was performed and by the isolating the serum was analyzed the sexual hormones levels and also by isolating ovaries, the primary, secondary and enteral follicles was accounted, and the results was analyzed by the ANOVA and tukey’s tests.Results:The results showed that the hops flower extract caused a significant increase in the hormones levels of estrogen, progesterone, and increasing the numbers of primary secondary and enteral follicles.Conclusion: Hops extract, probably by stimulating the secretion of hormones and with steroidal, flavonoids compounds, caused to increase the sexual hormones and the ovarian follicles Manuscript profile
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  3 - Study on sedative effects of different fractions of Hop (Humulus lupulus L.) extract compared with diazepam in rats
  رامین Shishehgar علی Rezaie ایلیاد Iesa beiglou محمد Jalilzadeh Hedayati CH Ahmadizadeh سلما Asl Faeghi A.R Ebadi
  Humulus lupulus is a medicinal plant which in Farsi is called "razak". The purpose of this research is, studying the sedative effects of polar, semi polar and non polar fractions extracted from Hop (Humulus lupulus. L) in comparison with diazepam in the animal model of More

  Humulus lupulus is a medicinal plant which in Farsi is called "razak". The purpose of this research is, studying the sedative effects of polar, semi polar and non polar fractions extracted from Hop (Humulus lupulus. L) in comparison with diazepam in the animal model of Rat. For conducting this research polar, semi polar and non polar fractions extracted from Hop based on the polarity of solvent. Then study continued with the injection of obtained extracts and other medicines to different groups of Wistar breed of rats. First group was injected with 100mg/kg of Polar fraction extract the second group, with 100mg/kg of Semipolar extract, the third group, with 100 mg/kg of non-polar extract of Humulus lupulus the fourth group with 2 mg/kg of Diazepam the fifth group with the same volume of DMSO used as solvent of injectable medicines an the sixth group was the control group and did not receive any drug. The method of injection was Intra peritoneal (IP) form. Statistical diagrams and results showed a significant decreasing of anesthetic induction time and increasing of sleeping time of Ketamin induced anesthesia, after IP injection of the Polar fraction extract of Humulus lupulus. The results obtained showed that the polar-fraction extract of Humulus lupulus has more sufficient sedative effects than diazepam and other under studied groups. Manuscript profile
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  4 - Using of OSC-PLS chemometry method for simultaneous determination of Gallium and Nickel in Echinacea purpurea and Humulus lupulus soil by UV-Vis Spectrophotometer
  مازیار Ahmadi Golsefidi R.A Rajabzadeh H.R Jalilian
   Echinacea purpurea and Humulus lupulus are two strategic medicinal plants in Golestan province and have many usage in pharmaceutical and food industries. Heavy metals like gallium and nickel in a standard concentration range are accepted for the soil of these two More

   Echinacea purpurea and Humulus lupulus are two strategic medicinal plants in Golestan province and have many usage in pharmaceutical and food industries. Heavy metals like gallium and nickel in a standard concentration range are accepted for the soil of these two plants. Extra concentration of the elements can aggregate and poisoned the metabolite activities in plants. Thus an accurate determination of concentration method is needed to control the amount of heavy metals in such a soils. Orthogonal signal correction – Partial least squares modeling is a powerful multivariate statistical tool applied to spectrophotometric simultaneous determination of mixtures of Gallium and Nickel. The method is based on the formation of the complex of PAN with Gallium and Nickel. The ISBO membrane shows enhanced selectivity for Ga3+ and Ni2+ but absorption spectra of these two complexes overlap strongly, thus it is difficult to analyze the compounds in their mixtures. In this study, the calibration model is based on absorption spectra in the 400-650 nm range for 25 different mixtures of Gallium and Nickel. A series of synthetic solutions containing different concentrations of Gallium and Nickel was used to check the prediction ability of the OSC-PLS model. The RMSEP were 0.3587 and 0.8496 for Gallium and Nickel, Respectively. Amount of Ga3+ and Ni2+ were determined 0.08 and 3.1 ppm in the plant soils respectively. Manuscript profile
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  5 - Investigation of effective compounds and antioxidant properties of five cultivar of hops (Humulus Lupulus L.) in different regions of Golestan province
  mostafa hamidi saeed navabpour mohsen fathi sadabadi
  10.30495/ejmp.2023.1978424.1717
  To investigate the effect of the environment on phenolic and flavonoid contents and antioxidant and phytochemical properties of essential oils in five cultivars of hop, in four regions of Golestan province (Gorgan, Aliabad, Galikesh, and Azadshahr), an experiment was co More

  To investigate the effect of the environment on phenolic and flavonoid contents and antioxidant and phytochemical properties of essential oils in five cultivars of hop, in four regions of Golestan province (Gorgan, Aliabad, Galikesh, and Azadshahr), an experiment was conducted as randomized complete block design with three replications during 2021-2022. Fruit extracts were prepared by soaking method using acetone solvent and the phenolic and flavonoid contents and the antioxidant properties were determined via Folin-Ciocalteu, aluminum chloride colorimetric, and DPPH method, respectively. Extraction of essential oils from fruit and identification of the compounds in the essential oil were carried out by water distillation method (Clevenger machine) and a gas chromatograph connected to a mass spectrometer (GC/MS), respectively. Overall, 32 compounds were identified, including Beta-acid, Alpha-acid, Co-humulone, total oil, Caryophyllene, Humulene, and Myrcene compounds, as the main components of the essential oil. Cascade cultivar in Gorgan region had the highest rate of phenolic and flavonoid contents as well as antioxidant activity, which can be related to the climatic conditions of the region and the higher potential of this cultivar. Also, all cultivars in Gorgan region had the highest content of secondary metabolites than others. Among the cultivated cultivars, Cascade and then Centennial had the highest content of secondary metabolites in all cultivation areas. Therefore, in order to achieve higher secondary metabolites, cultivation of Cascade in Gorgan region is recommend. On the other hand, Nugget in Galicash had the lowest content of secondary metabolites, which can be related to its lower potential in production of secondary metabolites and the climatic conditions of Galicash region which is located at a higher altitude and has a negative effect on the production of secondary metabolites. Therefore, considering the effect of different environmental conditions on the medicinal compounds of the species, it is recommended to evaluate the effect of the other factors, including the soil of the habitats. Manuscript profile