List of Articles اسیداوریک

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  1 - The Effect Of Hydroalcoholic Extract Of Oliveria decumbens on Kidney Functional Test and Histological Changes Induced by Cadmium Chloride in Adult Male Rat
  Maryam Rahimi Kazerooni Mokhtar Mokhtari Mehrdad Shariati Somayeh Rahimi Kazerooni
  Inroduction and Objective: Cadmium is an important environmental contaminant, and has various toxic effects on living beings. In this research, the effect of hydro alcoholic extract of Oliveria decumbens on the levels of Creatinin, BUN, Uric acidand kidney histological  More

  Inroduction and Objective: Cadmium is an important environmental contaminant, and has various toxic effects on living beings. In this research, the effect of hydro alcoholic extract of Oliveria decumbens on the levels of Creatinin, BUN, Uric acidand kidney histological  changes following toxicity induced by Cadmium Chloride in rat was investigated.Material and Methods: 48 adult male Wistar rats were divided into 6 groups of 8. These groups are as follow: the Control, left untreated; the Sham, just received distilled water, the experimental group 1, treated with 2mg/kg cadmium chloride; the experimental group 2 received 500 mg/kg oliveria extract, and experimental groups 3 and 4 initially received 2mg/kg cadmium chloride followed by 250 and 500 (mg/kg) extract respectively for 21 days. At the end of experiment, all groups weighed and blood samples were taken for measuring serum levels of creatinin, BUN and uric acid.after removing the kidneys, prepared tissue sections were studied by light microscopy. Results using statistical tests were one-way ANOVA followed by Tukey test.Results: Cadmium chloride caused significant decrease in body weight and significant increase in serum levels of creatinin, BUN, uric acid and damage was the kidney tissue in comparison with control and sham groups. Where as Oliveria decumbens extract cause significant increase in body weight and significant decrease in serum levels of creatinin, BUN ,uric acid, and improve kidney damage in groups poisoned with cadmium chloride (PConclusion: The results showed that Oliveria decumbens probably a protective effects against nephrotoxicity induced by cadmium chloride and the kidney parameters. Manuscript profile
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  2 - The Effect of Fe2O4Zn Nanoparticles on Kidney Tissue and Blood Biochemical Factors in Wistar Male Rats
  D. Rahmani Z. Hooshmandi Ferdowsi Sh.
  Nanoparticles should be investigated under the laboratory conditions for using in treatment of diseases. This study aimed to investigate the effects of nanoparticles of iron-zinc (Fe2O4Zn) on the factors kidney male rats Wistar. In this experimental study, 24 male Wista More

  Nanoparticles should be investigated under the laboratory conditions for using in treatment of diseases. This study aimed to investigate the effects of nanoparticles of iron-zinc (Fe2O4Zn) on the factors kidney male rats Wistar. In this experimental study, 24 male Wistar rats were randomly divided into 3 groups containing two experimental and one control group. The control group received 0.5 ml of saline solution but others groups received 0.5 ml of iron nanoparticle with concentration of 100 ppm and 200 ppm, respectively for 7 consecutive days injected intraperitoneally. On the second, seventh and fourteenth day after treatment, blood from the corner of the eyelids was done with capillary tube. Urea, uric acid, and creatinine were measured using ELISA method. Results showed that urea and uric acid levels in the seventh and fourteenth days after treatment at a dose of 100 ppm and 200 ppm were decreased. The creatinine values ​​at 2, 7 and 14 d after treatment 100 ppm and 200 ppm were increased. At a low dose, nanoparticles sediment in the connective tissue and cytoplasm of proximal and distal renal cell and at high doses of nanoparticles, deposit is made in cells of the proximal tubule and in the central part of kidney. Levels of urea and uric acid were reduced and creatinine was increased. The results of histological showed nanoparticle deposition in the kidney. The application of Fe2O4Zn nanoparticles in the biological system had no stable and long-term toxic effects on the animal body. Manuscript profile