List of Articles Bioactive compounds

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  1 - Cyanobacteria are a rich source of anticancer drugs
  bahareh Nowruzi
  The increase in cancer mortality as a result of excessive use of chemical drugs has made it one of the deadliest diseases worldwide. For this reason, most of the research today is focused on natural medicinal products. As a result, the aim of this article is to review t More

  The increase in cancer mortality as a result of excessive use of chemical drugs has made it one of the deadliest diseases worldwide. For this reason, most of the research today is focused on natural medicinal products. As a result, the aim of this article is to review the anticancer properties of cyanobacteria in the pharmaceutical and medical industry. To write this article, both the experiences and articles of the authors of the article and the latest articles available in the Web of Science, Pub Med, Google Scholar, Scopus and ScienceDirect databases have been used. Natural products are an important source of new medicinal compounds that not only have medicinal value, but are also used as building models for creating synthetic analogs. In the meantime, secondary marine metabolites extracted from cyanobacteria as a desirable source of potential new medicinal active compounds have structural diversity and diverse biological activities such as anti-inflammatory, antiviral, antimicrobial and anti-tumor properties. This review article examines the potential of compounds and metabolites of cyanobacteria as anticancer drugs and examines their chemical structure and mechanisms of actionof action. Manuscript profile
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  2 - Evaluation of the Antimicrobial Potential of Astragalus fasciculifolius Gum Extract Against Clostridium perfringens in Meatball Formulations Using Response Surface Methodology
  Najmeh Khademi Pour Anousheh Sharifan Hossein Bakhoda
  10.30495/fh.2023.73979.1142
  Astragalus fasciculifolius Boiss. is a native medicinal plant of Iran with a long history of traditional use. This study investigated the phenolic composition, antimicrobial activity, and growth dynamics of Clostridium perfringens when treated with ethanolic extracts More

  Astragalus fasciculifolius Boiss. is a native medicinal plant of Iran with a long history of traditional use. This study investigated the phenolic composition, antimicrobial activity, and growth dynamics of Clostridium perfringens when treated with ethanolic extracts of A. fasciculifolius gum. Phenolic profiling revealed hesperidin as the most abundant compound (17.61%). Extracts showed antimicrobial activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 156 and 78 mg/g against C. perfringens, respectively. Microscopy indicated membrane shrinkage and changes upon treatment. A quadratic model was developed to describe C. perfringens growth in meat over time at different extract concentrations and temperatures. Optimization predicted the lowest bacterial numbers at 7200.8 ppm extract concentration, 14.29 h storage time, and 4.0°C temperature. These results demonstrate that A. fasciculifolius gum possesses bioactive compounds with antimicrobial properties against foodborne pathogens. The extract could potentially be developed as a natural preservative for the food, cosmetics, and pharmaceutical industries. Manuscript profile
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  3 - Investigating the antioxidant and antibacterial properties of Froriepia subpinnata extract encapsulated with maltodextrin-whey concentrate
  raheleh alipour Abdollah Alizadeh Dariush Khademi Shurmasti
  Abstract Introduction: In recent years, the use of encapsulation has been associated with promising results to preserve and increase the biological effects of the active compounds of plant extracts. The present study was conducted to address of antioxidant and antibact More

  Abstract Introduction: In recent years, the use of encapsulation has been associated with promising results to preserve and increase the biological effects of the active compounds of plant extracts. The present study was conducted to address of antioxidant and antibacterial properties of the maltodextrin-whey concentrate-based encapsulation of Froriepia subpinnata hydroalcoholic extract. Materials and Methods: Froriepia subpinnata was extracted by ultrasonic method. Then its antioxidant and antibacterial activity were evaluated and compared in 500 and 1000 ppm levels. Results: The particle size of the encapsulated extract and the encapsulation efficiency measured 169.89 nm and 65.25% respectively. The encapsulated extract had significantly higher activity of DPPH free radical inhibition (91.25%) and beta-carotene (92.24%) than other treatments at 1000 ppm (P<0.05). In addition, the inhibition zone of Gram-positive bacteria Staphylococcus aureus and Bacillus cereus (26.02 and 22.03 mm respectively) and Gram-negative Escherichia coli and Salmonella enterica (20.49 and 19.38 mm respectively) in 1000 ppm encapsulated extract has also more extend than others (P<0.05). Conclusion: The results showed that the maltodextrin-whey concentrate-based encapsulation significantly improved Froriepia subpinnata extract antioxidant and antibacterial properties. Therefore, it is possible to use 1000 ppm of encapsulated Froriepia subpinnata extract as a suitable alternative for synthetic antibiotics and antioxidants. Manuscript profile
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  4 - Saffron Nanoemulsions: an emphasis on the two recent patents for ultrasonic Nanoemulsion of saffron
  H. Ahari Sima Moradi A. A. Anvar Sara Allahyaribeik
  Nanoemulsions are a colloidal dispersion of oil/water or water/oil phases stabilized by emulsifiers. The physicochemical properties of nanoemulsions have made them suitable candidates for the delivery of bioactive compounds. Oil-in-water nanoemulsions are proper carrier More

  Nanoemulsions are a colloidal dispersion of oil/water or water/oil phases stabilized by emulsifiers. The physicochemical properties of nanoemulsions have made them suitable candidates for the delivery of bioactive compounds. Oil-in-water nanoemulsions are proper carriers for hydrophobic and water-in-oil or water-in-oil-in-water nanoemulsions are good carriers for hydrophilic compounds. Saffron is an expensive bulbous stemless herb whose different bioactive ingredients including crocins, crocetin, safranal, picrocrocin, and essential oils have valuable nutritional, medicinal, pharmaceutical, and antimicrobial properties. The use of nanoemulsion technology is a promising approach for saffron processing. The emulsion liquid membrane is one of the effective techniques for extracting saffron bioactive. On the other hand, encapsulating saffron extract in nanoemulsion droplets can increase the stability, bioavailability, and controlled release of bioactive ingredients of saffron. Due to its inherent antimicrobial activity, saffron can be used in the form of nanoemulsion coatings to increase the quality and shelf life of food products. In this study, the existing studies on saffron nanoemulsions processing were reviewed. The application of nanoemulsion techniques for saffron extraction, saffron bioactive nanoencapsulation, as well as the probable preservative properties of saffron essential oils for food packaging have been discussed. This article also reveals information on two recent patents on the subject of saffron nanoemulsion by ultrasonic method. Manuscript profile
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  5 - Bioactive products of cyanobacteria and microalgae as valuable dietary and medicinal supplements
  S. A.A. Anvar B. Nowruzi M. Tala
  10.30495/jfh.2021.1925461.1310
  Cyanobacteria and microalgae have great potential to produce a wide variety of biotoxic and non-toxic biologically active compounds and could lead to the development of the food and pharmaceutical industries soon. The commercial proliferation of algae on a large scale i More

  Cyanobacteria and microalgae have great potential to produce a wide variety of biotoxic and non-toxic biologically active compounds and could lead to the development of the food and pharmaceutical industries soon. The commercial proliferation of algae on a large scale is due to their ability to produce a wide range of valuable secondary metabolites such as polyunsaturated monounsaturated fatty acids, polysaccharides, glycerol, glycoproteins, antioxidant compounds, and antibiotics. Today, with the potential spread of bacterial resistance and reduced efficacy of existing antibiotics, researchers are looking to find new antibiotics among the products produced by microalgae. However, many cyanobacterial strains contain toxic compounds that cause the death of many humans and animals. In this review article, an attempt has been made to introduce valuable biologically active products along with various types of cyanotoxins in foods and treatment methods by collecting the latest research. It is hoped that the results of this study could pave the way for the introduction of valuable metabolites produced by cyanobacteria and microalgae in the food and pharmaceutical industries. TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //TRANSLATE with xEnglishArabicHebrewPolishBulgarianHindiPortugueseCatalanHmong DawRomanianChinese SimplifiedHungarianRussianChinese TraditionalIndonesianSlovakCzechItalianSlovenianDanishJapaneseSpanishDutchKlingonSwedishEnglishKoreanThaiEstonianLatvianTurkishFinnishLithuanianUkrainianFrenchMalayUrduGermanMalteseVietnameseGreekNorwegianWelshHaitian CreolePersian //  TRANSLATE with COPY THE URL BELOW BackEMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster PortalBack// Manuscript profile
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  6 - Noncorrelation between Growth and Zerumbone Production in Zingiber zerumbet Smith
  Mahanom  Jalil Nurul Alwakil Boon Chin Tan MOHAMAD SUFFIAN MOHAMAD ANNUAR Norzulaani Khalid
  Root cultures were established through adventitious roots obtained either from direct or indirect organogenesis. The frequency of root response, number of roots per explant, root length, and zerumbone production were influenced by the concentrations and the types of aux More

  Root cultures were established through adventitious roots obtained either from direct or indirect organogenesis. The frequency of root response, number of roots per explant, root length, and zerumbone production were influenced by the concentrations and the types of auxins, initial root inoculum and the strength of the basic Murashige and Skoog (MS) salt in the culture media. It was crucial to decide the type of root explant and optimum media that supported both growth and bioactive compound production in the root cultures. In our study, we found that there was a noncorrelation in the optimised media for growth and zerumbone production in the root cultures of medicinal ginger Zingiber zerumbet Smith. Full strength (MS) medium was the optimum media for specific growth rates whereas zerumbone accumulation was higher in half strength MS medium for adventitious roots from direct (AdRD) and indirect (AdRId) organogenesis. AdRD was chosen over AdRId although the specific growth rate achieved was higher in the latter (7.2 x 10-2µ) than the former (5.5 x 10-2µ) based on the zerumbone accumulation performance. Subsequently, these AdRD root cultures were elicitated with methyl jasmonate which showed ten-folds increase in zerumbone production than the controls. This study could provide a scalable protocol for the production of zerumbone from adventitious root culture in the future. Manuscript profile
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  7 - Simultaneous optimization of extraction of bioactive compounds and antioxidant activity of Ammi visnaga (L.) Lam aerial parts using response surface methodology
  Zineb El Jabboury Smail  Aazza Driss Ousaaid Oumaima  Chater Uroš  Gašić Peđa  Janaćković Zora Dajic  Stevanovic Stefan  Kolašinac Meryem  Benjelloun Lahsen  El Ghadraoui
  In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solven More

  In this report, different extracts from the aerial parts of Ammi visnaga (L.), e.g., flowers, leaves, and stems were prepared using water, methanol, and ethanol. To optimize the extraction process, the design of mixtures was carried out using different extracting solvents and their combinations. The special cubic model explained the variance of the TPC and the antioxidant activity of the extracts at a level of R2 > 95%. In general, the analysis of the model-derived response surfaces revealed that in binary mixtures (50% ethanol + 50% methanol), the yielded values of phenolic compounds and the antioxidant activity increase with the water proportion of different prepared mixtures. The ability of the quaternary mixture to extract the phenolic compounds was also positively and significantly influenced by the water content, creating a mild polar medium for the extraction of phenolic compounds. The phenolic profile of different extracts under study revealed the presence of a cocktail of active ingredients, including chlorogenic acid, caffeic acid, rutin, p-coumaric acid, etc. especially the flower extract of A. visnaga (L.). Manuscript profile