Chemical composition and cytotoxicity of the essential oil of Tanacetum abrotanifolium (L.) Druce (Asteraceae) from Iran

Subject Areas : Essential Oils: Classical and Advanced Techniques for Isolation and Biological Activities

Ali Sonboli ¹ , Sepideh Ghilichpour ² , Mohsen Farhadpour ³ , Mitra Arman ⁴

1 - Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, 1983969411, Tehran, Iran
2 - Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran
3 - Department of Plant Bioproducts, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran
4 - Department of Biology, Payame Noor University, P.O. Box: 19395-3697, Tehran, Iran

Received: 2022-06-05 Accepted : 2022-09-15 Published : 2022-09-01

Keywords: Cytotoxicity activity, <i>Tanacetum abrotanifolium</i>, GC-MS analysis, Essential oil, Asteraceae, Aerial parts,

Abstract :

Chemical composition of the essential oil obtained from aerial parts of Tanacetum abrotanifolium (L.) Druce (Asteraceae) was investigated. Plant sample was collected at full flowering stage from West Azerbaijan Province of Iran. The hydrodistilled essential oil was analyzed by GC-FID and GC-MS. The major compounds were found to be (E)-sesquilavandulol (26.6%), camphor (16.2%) and 1,8-cineole (12.9%). Cytotoxicity activity of the oil was evaluated against four cancer cell lines, of which IC50 values estimated to be 312, 312, 625 and 1250 μg oil/mL for the monkey kidney Vero, human breast adenocarcinoma (MCF7), choriocarcinoma (JET 3) and human colon adenocarcinoma (SW480) cell lines, respectively.

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