A new lupane triterpene glycoside from Euphorbia boissierana Prokh.

Subject Areas : Phytochemistry: Isolation, Purification, Characterization

Lili Gvazava ¹ , Nana Gorgaslidze ² , Markus Ganzera ³ , Alexander Skhirtladze ⁴

1 - TSMU Iovel Kutateladze Institute of Pharmacochemistry, 36 P. Sarajishvili st., 0159 Tbilisi, Georgia
2 - TSMU Iovel Kutateladze Institute of Pharmacochemistry, 36 P. Sarajishvili st., 0159 Tbilisi, Georgia
3 - Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria
4 - TSMU Iovel Kutateladze Institute of Pharmacochemistry, 36 P. Sarajishvili st., 0159 Tbilisi, Georgia

Received: 2017-06-14 Accepted : 2017-08-12 Published : 2017-09-01

Keywords: lupane, Euphorbia boissierana Prokh, Euphorbiaceae, betulin, triterpene glycoside,

Abstract :

Euphorbia plants displayed a wide range of biological activities including anticancer, antitumor, anti-diabetic, anticoagulant, antiproliferative, antioxidant, cytotoxic and modulation of multidrug resistance. Euphorbia boissierana Prokh. is one of the 45 species growing in Georgia. A new lupane triterpene glycoside (1) was isolated from the MeOH extract of the aerial parts of E. boissierana. The structure of 1 was elucidated as 3-[(O-β-D-fucopyranosyl-(12)-β-D-glucopyranosyl)oxy] lup-20(29)-en-3β, 28-diol. Structure elucidation was accomplished through the extensive use of 1D- and 2D NMR experiments including 1H–1H (COSY) and 1H–13C (HSQC, HMBC) spectroscopy along with ESI-MS and HR-ESI-MS.This is the first report of the isolation of betulin glycoside from the genus Euphorbia.

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