Subject Areas : biology

Fatemeh Jamallou ¹ (Assistant Professor, Department of Biology, Qom Branch, Islamic Azad University, Qom, Iran. )

Received: 2023-08-21 Accepted : 2024-07-08 Published : 2024-01-31

Keywords: Lipexan capsule, cholesterol, triglyceride, LDL, Gemfibrozil, Herbal capsules, Mouse.,

Abstract :

Purpose: The role of plants in reducing blood lipids and thus reducing the risk of cardiovascular diseases is known. In this regard, the aim of the current study is to investigate the effect of Lipexan capsules in reducing triglycerides, cholesterol and LDL in an animal model.

Materials and methods: In this research, 40 male Wistar rats with an approximate weight of 200±20 grams were used. Mice were randomly divided into 5 groups of 8, including the control group with diet and the control group with high-fat diet (for 21 days), the treatment group with lipexan capsules with a dose of 90, the treatment group with lipexan capsules with a dose of Min and the treatment group with Fibrozil jam capsules (for 30 days) were divided. Blood sampling was done at the end. Cholesterol, triglyceride and LDL values were measured. One-way analysis of variance was used to analyze the data.

Findings: The serum concentrations of cholesterol, triglyceride and LDL in the groups treated with Lipexan Min and 90 capsules and the Fibrozil Jam group were significantly reduced compared to the control group with standard food and the control group with high-fat food.

Conclusion: Lipexan capsule has an effect on the concentration of cholesterol, triglyceride and LDL in hyperlipidemic rats. Lipexan capsules can be used to reduce the level of blood lipids, as an effective treatment or prevention method for hyperlipidemia.

References:

1. Kusters DM, Avis HJ, Braamskampetal MJ & Huijgen R. Inheritance pattern of hypercholesterolemia and markers of cardiovascular risk familial. Journal of Lipid Research. 2013; 54(9): 2543-2549.
2. Xie W, Zhao Y & Du L. Emerging approaches of traditional Chinese formulas for the treatment of hyperlipidemia. Journal of Ethnophamacology. 2012; 140(2): 345-367.
3. Babaei Garmkhani S, Youssef Vand N, Nasodi G & Hatami K. The effect of oral consumption of (Caspicum annuum) and (Piper nigrum) on serum cholesterol levels in small laboratory mice. Journal of Nutritional Sciences and Food Industries of Iran. 2014; 10(3): 13-20. [in persian]
4. Athyros VG, Tziomalos K, Karagiannis A & Mikhailidis D. Dyslipidemia of obesity metabolic syndrome and type 2 diabetes mellitus: the case for residual risk reduction after ststin treatment. The Open Cardiovascular Medicine Journal. 2011; 5: 24-34.
5. Mahamuni SP, Khose RD, Menaa F & Badole SL. Therapeutic approaches to drug targets in hyperlipidemia. Biomedicine. 2012; 2(4): 137-146.
6. Shaori M, Mohit A, Ansari Pirsaraei Z, Taghizadeh & M. The effect of dill essential oil on some blood parameters, egg yolk cholesterol concentration, hatching power and chick quality in broiler chickens. Livestock production research. 2011; 3(6): 15-22. [in persian]
7. Rafati A, Moradi S, Esmaili Dehaj M, Jalali B & Yaghmai P. Comparing the effect of dill seed aqueous extract with lovastatin in reducing blood lipids and lipoproteins in large laboratory rats. The Journal of Shahid Sadoughi University of Medical Sciences. 2006; 13(5): 41-49. [in persian]
8. Gharib Naseri MK, Mard A & Farboud Y. The effect of dill fruit extract on rat uterine contractions. Iranian Journal of Basic Medical Sciences. 2006; 8(4): 263-270.
9. Ghorbanian B, Mohammadi H & Azali Alamdari K. The effect of aerobic exercise with sumac supplement on total antioxidant capacity, insulin resistance index and anthropometric indices in type 2 diabetic women. Complementary Medicine Research Quarterly. 2016; No. 1: 1811-1805. [in persian]
10. Reofi A, Mardani M, Sabbagh M, Delfan B & Tarrahi MJ. Investigating the effect of sumac in reducing LDL cholesterol compared to Lostatin. Scientific Journal of Ilam University of Medical Sciences. 2008; 17(3): 51-58. [in persian]
11. Zand S, Mahmoudi M, Khajeh Godari M, Asgari P, Abdullahi M & Rafiei F. The combined effect of apple vinegar and honey on blood lipids. Journal of Complementary Medicine. 2015; No. 1. [in persian]
12. Moslinejad B, Avizeh R, Razi Jalali M & Jahanmardi A. Comparative evaluation of the effect of garlic and atorvastatin on changes in lipid profiles in dogs. Iranian Veterinary Journal. 2015; 12(2). [in persian]
13. Shahverdi A, Kheiri F, Faghani M, Rahimian Y & Rafiee A. The effect of use red
pipper (Capsicum annum L.) and black pipper (Pipper nigrum L.) on performance and hematological parameters of broiler chicks. European Journal of Zoological Research. 2013; 2(6): 44-48.
14. Mohiti Ardakani J, Akbarian Z & Nazarian A. The effect of cumin essential oil on blood glucose and lipids in rats. Journal of Shahid Sadoughi University of Medical Sciences. 2011; 19(3): 388-397. [in persian]
15. Barreto MSR, Menten JFM, Racanici AMC, Pereira PWZ & Rizzo PV. Plant extracts used as growth promoters in broilers. Braz J Poultry Sci. 2008; 10: 109-115.
16. Slyper AH, Zvereva S & Schectman G. Insulin resistance is not major determinant of lowdensity lipoprotein particle size. Metabolism. 1997; 46(11): 275-280.
17. Khalid S. Al-Numair, Type II diabetic rats and the hypolipidemic effect of camel milk. Journal of food, Agriculture & Environment. 2010; 8(2): 77-81.
18. Mirseyed F, Shiravi A & Heidari Nasrabadi M. Effect of alchol extract of fennel seed injection of gonadotropin and testosterone in male Wistar rats. Iran J Res Anim Biol. 2008 1(1): 49-56.
19. Law MR. Lowering heart disease risk with cholesterol reduction: evidence from observational studies and clinical trials. Eur Heart Journal Supplements. 1999; 1(20): S3-S8.
20. Decker EA. The role of phenolics, conjugated linoleic acid, carnosine, and pyrroloquinoline quinine as nonessential dietary antioxidants. Nutr Rev. 1995; 53(3): 49-56.
21. Singh RB, Niaz AM & Ghosh S. Randomized controlled trial of oxidant vitamin and Cardioprotective diet on hyperlipidemia, oxidative stress and development of experimental atherosclerosis cardiovasc. Drug ther. 1995; 6(9): 763-771.
22. Velayuthom R, Sankaradoss N & Ahamed KF. Protective effect of tannins from Ficus racemosa in hyper cholesterolemia and diabetes included vascular tissue damage in rats. Asian Pac J Trop Med. 2012; 5(5): 367-373.
23. Karami M, Mokhtari M & Sharifi E. Investigating the effect of aqueous-alcoholic extract of parsnip leaves on blood glucose and lipids in adult male rats treated with streptotocin. Journal of Fasa University of Medical Sciences. 2012; 4(1): 81-90. [in persian]
24. Mancini GB, Tashakkor AY, Baker S & et al. Diagnosis prevention, and management of statin adverse effects and intolerance Canadian Working group consensus update. Can J Cardiol. 2013; 29: 1553-1568.
25. Alhilal MK, Supuh AM & Hapra N. Borage oil rich in gama linolenic acid (GLA) reduces cardiovascular disease (CVD) risk factors in hamsters fed in diet rich in saturated fatty acids (SFAS) and cholesterol. Bas J Vet Res. 2014; 1: 54-65.
26. Cheraghi J, Kimiagar M & Pileh Varian AA. The effect of hydroalcoholic extract of borage flower on serum lipid profile in mice and its comparison with lovastatin. Scientific Journal of Ilam University of Medical Sciences. 2015; 24(23): 1-9
27. Bahrami T, Yusuf-vand, N, Slimi Esfahani D & Oryan Sh. Effect of hydroalcoholic extract of pecan and allspice plants on blood lipid profiles in NMRI mice. Scientific Journal of Ilam University of Medical Sciences. 2015; 24(5): 1-7. [in persian]
28. Moradkhani T, Eidi M & Saeedinia AR. Hypolipidemic effect of dill essential oil in hyperlipidemic rats. Developmental Biology Scientific Research Quarterly. 2015; 9(1): 1-10. [in persian]
29. Jafarian S, Varkohi AK & Tarrahi MJ. Investigating the therapeutic effects of vinegar and water on hyperlipidemia compared to lovastatin. Yafteh. 8(28). [in persian]
30. Fushimi T, Suruga K, Oshima Y, Fukiharu M, Tsukamoto Y & Goda T. Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats fed a cholesterol-rich diet. British Journal of Nutrition. 2006; 95(5): 916-924.
31. Vakili J, Dabbagh Niko Kheslat S & Khanvari T. The effect of 8 weeks of garlic supplementation on body composition and some cardiovascular risk factors in overweight people. Journal of Neyshabur Faculty of Medical Sciences. 2015; 4(3): 28-39. [in persian]