Compare resistance and antifngal effects of Fluconazole, Itraconazole , Ketoconazole and nystatin on ( Candida albicans) isolated from Vulvovaginitis in Qom in 1395
Subject Areas : microbiology
Ameneh basem hamid
1
(Student of Microbiology Department, Qom Branch, Islamic Azad University, Qom, Iran.)
Mohammad Dakhili
2
(Medical of Department, Qom Branch, Islamic Azad University, Qom, Iran.)
Mohammad Ali Ghasem Zadeh
3
(Chemistry of Department, Qom Branch, Islamic Azad University, Qom, Iran.)
Keywords: Ketoconazole, Candida albicans, Nystatin, Itraconazole, Fluconazole,
Abstract :
Background & Objectives: Candidial vulvovaginitis is a female genital system infection that occurs due to the overgrowth of Candida species, especially with Candida albicans. The long administration of the current antifungal drugs may cause resistance. it is essential to understand the efficacy pattern of therapeutic agents against the isolated Candida species from vaginitis. The aim of this research was the investigation of the antifungal drug resistance pattern in Candida species isolated from vaginitis against azole current drugs. Materials & Methods: In this cross-sectional study that was performed on100 vaginit specimens. All specimens were examined under direct microscopy and culturing. Furthermore, complimentary tests such as culture on candida chrom agar, corn meal agar, germ tube test, susceptibility to cycloheximide and sugar assimilation test were performed to differentiate the Candida albicanse from each other. The effect of the current fluconazole, itraconazole , nystatin, ketoconazole disk diffusion method was also tested. Data were analyzed by SPSS using independent Chi-square. Results: Out of 100 vaginit specimens 35 cases were diagnosed were Candida albicans. Diameter of average of inhabitation zone were in Ketoconazole 21.80±5.85 mm, Iitraconazole 18.42 ± 5.20 mm, Nystatin 15.97 ± 2.28 mm and Fluconazole 6.82 ±12.02 mm. CONCLUSION: Our results showed 35% specimens were diagnosed with isolated agents Candida albicans. that the most effective drugs against Candida albicans was Iitraconazole. Hospital wards fungi was resistant to Fluconazole and sensitive to Ketoconazole. Introduce Ketoconazole of can be useful in treatment of chronic vaginal candidiasis.
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