Small Interference RNA (siRNA)

Subject Areas : genetic

Mohammad Abootaleb ¹ , narjes Mohammadi Bandari ²

1 - دانشجوی دکتری دانشگاه آزاد اسلامی واحد قم
2 - دانشجو

Received: 2016-04-09 Accepted : 2016-05-14 Published : 2016-08-22

Keywords: RNA Interference, gene silencing, infection,

Abstract :

Infectious diseases caused by microorganisms are still major causes of death all over the world and the increasing number of their resistant strains results in great concerns. Using RNA interference, many therapeutic potential have for the treatment or prevention of diseases. This RNA have vital roles in transcriptional regulation and post-transcriptional gene. The current, against many antibiotic in bacteria has been accessed resistance and even for some of them there is no antibiotic. And alternative methods to treat them severely felt. Since the discovery of gene silencing using RNA interference (RNAi), there has been a revolution in its medical applications. Local transfer of siRNA for treat diseases is rapidly expanding and it is hoped that in the future could find use in clinical trials. Local injection reduces the toxic effects and increase the availability of Drugs to tumor cells. In this review, the current clinical status of siRNA therapeutics,The advantages and challenges of using it are investigated