Effect Shrak cartilage on number and activity T-cell regulating cells in stomach cancer paitents

Subject Areas : biology

razieh zareii ¹ , محمد زهیر حسن صراف ² , ابوالقاسم عجمی ³ , داریوش مسلمی ⁴ , امراله مصطفی زاده ⁵

1 - کارشناسی ارشد
2 - عضو هیئت علمی
3 - عضو هیئت علمی
4 - عضو هیئت علمی
5 - عضو هیئت علمی

Received: 2016-04-16 Accepted : 2016-06-14 Published : 2016-08-22

Keywords: Treg, IL-4, gastric cancer, IFN-γ, cytokine TGF-β,

Abstract :

Introduction: Gastric cancer or gastric cancer, the fourth most common cancer and the second most common cancer in Iran and around the world Srtankshndh safety Ast.paskhhay in gastric cancer include innate and adaptive immunity Treg The cells in several malignancies including gastric cancer in Myyabdslvlhay increase in Treg immune response settings, maintaining homeostasis and immune tolerance, autoimmunity and cancer survival primarily as a treatment for cancer control Myknd.ghzrvf shark is .. Shark cartilage, a protein that angiogenesis (angiogenesis) in vitro and stop animal models. A network of blood vessels tumors need to survive and grow, so by blocking the blood supply to the tumor disappears,It was observed that in the group treated with shark cartilage cell viability Treg an average of 48/1% before treatment to 2/0% post treatment decrease the amount of cytokine inhibition of TGF-β from pg / ml183 before treatment pg / ml110 after treatment decreased, but the amount of cytokines in serum IFN-γ (pattern of cytokine TH1) of pg / ml160 before treatment pg / ml187 after treatment increased the amount of IL-4 (pattern of cytokine TH2) of pg / ml37 before treatment pg / ml30 after treatment decreased Is. In the control group there was no significant difference in the measurement.Final argument: Shark cartilage in people suffering from gastric cancer cell depletion inhibitory Treg and cytokine inhibiting TGF-β as well as a reduction in IL-4 (Aymvnyty cells, TH2) and increased production of IFN-γ (Aymvnyty cells, TH1) to enhance immune responses anti-tumor cell.