The effect of iron oxide nanoparticles on liver, kidney and spleen in male rats
Subject Areas : biology
Keywords: liver, spleen, Iron oxide nanoparticles, kidney, Rat,
Abstract :
Iron oxide nanoparticles have been used as contrast agents in the MRI and in thermal therapy for cancercells. However, their, their adverse effects on human health have not been fully investigated. In thisexperience the effect of iron oxide nanoparticles on morphological and pathological changes of livertissue, kidney and spleen tissue in rats was investigated. Mice in Three experimental groups werereceived iron oxide nanoparticle (20, 50 and 150 μg/kg) which was dissolved in 1 ml of distilled water bygavage tube daily and for fifteen days. The control group was received 1 ml of distilled water daily.Results showed morphological and pathological changes in the tissues. Meanwhile results showed thatthis change was depended to the dose. In liver, tissue necrosis, inflammation and increased number oflymphocytes was observed. Meanwhile port area was extensive. Necrosis of kidneys and destruction ofbowmen9s capsule and glomerular atrophy was observed. Meanwhile atrophy of spleen tissue was severeand loss of red pulps and white pulps increased. According to the results it seems that Iron oxidenanoparticles have toxic effects on the liver, kidney and spleen tissues that this effects increases withincreasing dose.