Evaluation Of native probiotic Lactobacillus brevisin Iran passive avoidance learning in male wistar rats under chronic stress
Subject Areas :Esmaiel Mokhtari Farahani 1 , Hamid Reza Mohajerani 2 , Sima Nasri 3 , Parvaneh Jafarei 4 , Maryam Tajabadi Ebrahimi 5 , Nafiseh Maghsoodi 6 , Saeed Tahmasebi 7
1 - دانشجوی کارشناسی ارشد، رشته زیست شناسی، دانشگاه پیام نور،ایران.
2 - دانشگاه آزاد اسلامی واحد اراک، دانشکده علوم پایه، استادیار گروه میکروبیولوژی،اراک.ایران
3 - استاد یار، رشته زیست شناسی، دانشگاه پیام نور، ایران
4 - دانشگاه آزاد اسلامی واحد اراک، دانشکده علوم پایه، استادیار گروه میکروبیولوژی،اراک.ایران.
5 - دانشگاه آزاد اسلامی واحد تهران مرکز، دانشکده علوم پایه، استادیار گروه زیست شناسی،تهران.ایران.
6 - دانشگاه آزاد اسلامی واحد علوم دارویی، تهران، دانشکده علوم وفناوری‌های نوین، کارشناسی ارشد میکروبیولوژی، تهران.ایران.
7 - دانشگاه آزاد اسلامی واحد اراک، مسئول آزمایشگاه دانشگاه علوم پزشکی، اراک.ایران
Keywords: passive avoidance learning, Gavage, Stress, Probiotic,
Abstract :
Inroduction and Objective: Probiotics are food supplement and pharmaceutical substance prepared from living microorganisms, which with enhancement of microbial equilibrium of intestinal microbiota insert useful effects on the host (human/animal). Researches were indicated that nutrients could affect the brain and neurohormones via vagus nerve. So it is probable that probiotics can regulate some parts of brain activities and result it better function. Materials and Methods: In this study 24 male wistar rats with 95-118 grams weight range and 4 weeks age were used and they divided to four groups randomly: two groups as control, with and without stressed rats. Two other groups were received were gavaged with 1 ×10 9 cfu/ml of probiotics. Results: Data of this research indicated that in the control groups, stress were increased the time of latency in dark component significantly (pConclusion: Results of this study showed that the Lactobacillus brevis isolated from Tarkhineh dough, enhance the on passive avoidance learning in maleWistar rats under stress conditions. Our data demonstrate the positive effect of this probeotic on learning and memory.