Study on Liver Development Of Newborn Male Rats from Mothers Treated with Dnazol

Subject Areas :

Forogh Massomi ¹ , Mehrdad Shariati ² , Akbar Zeraatpisheh ³

1 - دانشگاه آزاد اسلامی واحد کازرون، دانشجوی کارشناسی ارشد گروه بیولوژی، کازرون. ایران.
2 - دانشگاه آزاد اسلامی واحد کازرون، دانشیار گروه بیولوژی، کازرون. ایران
3 - دانشگاه آزاد اسلامی واحد کازرون، استادیار گروه بیولوژی، کازرون. ایران

Received: 2015-06-09 Accepted : 2018-08-04 Published : 2013-04-21

Keywords: Newborn Male Rat, DanazolLFT,

Abstract :

Inroduction and Objective: Liver is an important organ with special function in metabolism of drugs. Danazol is a drugs for treatment of some patients. The present study was conducted to evaluate the effect Danazol on function, liver enzymes including ALT, AST, ALPand blood biochemical factors such as protein and albuminand histological changes of liver in newborn male rats.Materials and Methods:In this experimental study 40 newborn male rats wistar strain divided into 5 group of 8.the newborns were taken from pregnant mothers which divided to the control group that received nothing, the sham group that received solvent (1.6H2O+0.4 ethanol) and three experimental groups that received 100, 200 and 400 mg/kg b.w. Danazol in the pregnancy period for 21 days orally. In 22thdays after parturition, the newborns weighted and the blood samples prepared for AST, ALT, ALP, albumin, protein a valuating by Technicon RA1000 autoanalyzer and pars Azmoon kit made in Iran. In addition , the newborns liver evaluated by HandE histological staining methods.Results:The body weight in the experimental group showed decreasing and the concentration of AST, ALT and ALP showed increasing significantly (PConclusion: It can be concluded that Danazol causes weight loss by increasing the levels of liver  enzymes also this drug causes necrosis and damaging in liver tissuehowevermore investigations are needed.