The Effect Of Agonist Of Serotonergic ReceptoreAndagonist Of Cannabinoidergic Recepror (CB1) on Anxiety-Like Behaviors Of Central Amygdalein the Plus-Maze Model in Wistar Rat

Subject Areas :

Saba Taheri ¹ , Shahrbano Oryan ² , Mohamad Reza Zarrindast ³ , Amaneh Rezayof ⁴

1 - دانشگاه آزاد اسلامی واحد علوم وتحقیقات تهران دانشجوی دکتری فیزیولوژی جانوری، گروه زیست شناسی، تهران. ایران.
2 - استاد دانشکده علوم زیستی، گروه زیست شناسی، دانشگاه خوارزمی، تهران. ایران
3 - دانشگاه آزاد اسلامی واحد علوم وتحقیقات تهران، دکتری فارماکولوژی، گروه زیست شناسی، تهران. ایران
4 - دکتری فیزیولوژی جانوری، دانشکده علوم زیستی، گروه زیست شناسی دانشگاه تهران، تهران. ایران.

Received: 2015-06-09 Accepted : 2018-08-04 Published : 2013-04-21

Keywords: ACPA, Serotonergic Receptore (5-HT1), elevated plus maze, Rat,

Abstract :

Inroduction and ObjectiveAnxiety is a respond of anorganism to a likely treat which can disturb the cellular homstasis. Serotonergic and cannabinoidergic systems contribute in many physiologic behaviors like anxiety. This study was done to investigate the effect of cannabinoidergic system on central amygdala and its interference with serotonergic system on anxiety in "Elevated Plus Maze"Materials and Methods:After a week resting , several doses of Arachidonile Cyclo Propyle Amide (ACPA) and selected Agonist of serotonergic receptore 1 (5-HT1) with commercial name of " CP94253 Hydrochloride" has been Microinjected into Central Amygdala of rat. The presence in Open Arms Time percent  (OAT%) and the number of entrance  into the open arms percent (OAE%) and locomotor activity (LA) was measured.Results: Injection of ACPA has no effect anxiety behaviors. Injection of high doses of agonist of serotonergic receptor has also got no effect of anxiety. microinjection of  non effective dose of CP94253 Hydrochloride into Central Amygdala could suppres the anxyolitic effect of ACPA.Conclusion: Presynaptic cannabinoid receptore of CB1 could inhibit many neurotransmitters secration like serotonin and it seems that serotonin agonist could replace the inhibited neurotransmitter by ACPA. nsi-language: EN-US;mso-fareast-language:EN-US;mso-bidi-language:FA'>ACPAباشد