The Effect of Ethanol Extraction of Aloe vera on Certain Biomarkers of Cardiovascular Disease in Mice Treated with Nanoparticles of Titanium Dioxide

Subject Areas :

Fereshteh Javan Masoomi ¹ , Jila Talat Mehrabad ² , Roghayeh Babri Bonab ³

1 - دانش آموخته کارشناسی ارشد زیست شناسی سلولی-تکوینی، گروه زیست شناسی، دانشکده علوم، واحد کرج، دانشگاه آزاد اسلامی، البرز. ایران
2 - استادیار گروه شیمی، دانشکده علوم، دانشگاه آزاد اسلامی واحد بناب، بناب.ایران.
3 - استادیار گروه زیست شناسی، دانشکده علوم، دانشگاه آزاد اسلامی واحد بناب، بناب.ایران

Received: 2016-12-08 Accepted : 2018-08-04 Published : 2017-01-20

Keywords: Sialic Acid Tom, aloe vera, cardiovascular disease, Troponin I, Creatine Kinase MB, Malondialdehyde, Nanoparticles of Titanium Dioxide,

Abstract :

Inroduction & Objective: The effect of ethanol extraction of Aloe vera on certain biomarkers of cardiovascular disease in mice treated with titanium dioxide nanoparticles was studied.Material and Methods: Mice were received titanium dioxide nanoparticles with density of 100 milligrams per kg and ethanol extraction of aloe vera plant with density of 100, 200 and 300 milligrams per kg for 30 days. Plasma levels ofmalondialdehyde, rich sialic acid, troponin I and creatine kinase MB at the end of treatment was evaluated. The antioxidant activity of ethanol extraction in Aloe Vera using free radical DPPH and total phenol levels were considered.Results: The results showed that giving titanium dioxide nanoparticles through the stimulation of oxidative activity had a significant increase in plasma levels of malondialdehyde (MDA). Plasma levels of troponin I, creatine kinase MB and rich sialic acid also significantly increased. With increasing density of aloe vera, the total phenol and antioxidant activity of ethanol extraction increased. Giving the extraction significantly reduced the plasma levels of biomarkers of cardiovascular damage in mice treated with titanium dioxide nanoparticles.Conclusion:According to the results, ethanol extraction of aloe vera as an antioxidant compound is able to reduce the levels of cardiovascular damage in mice treated with titanium dioxide nanoparticles.