The effect of eight weeks of intense circular exercise on serum irisin levels in inactive women
Subject Areas : Physical Activity and Health
javad almasi
1
,
Sajad Mohamadbigi
2
,
Fatemeh Zakery Pur
3
1 - Assistant Professor, Department of Sports Physiology, Islamic Azad University, Hamadan Branch
2 - Graduated in sports physiology Khoramabad Branch, Islamic Azad University, Khramabad, Iran.
3 - Graduated in sports physiology Hamedan Branch, Islamic Azad University, Hamedan, Iran.
Keywords:
Abstract :
Background: The Effect of 8 weeks of High Intensity Ciruit Training on serum levels of Irisin in overweight sedentary females Abstract Irisin is a myokine released from a membrane protein FNDC5 and has positive effects on carbohydrate metabolism. The aim of this study was to investigate the effect of 8 weeks of Hight intensity circuit training on serum levels of Irisin in overweight sedentary females. the results of this study can help by improving the level of the aerobic fitness, weight loss and increasing serum levels of Irisin. Its also could explain the benefits of these exercises to enhance women's exercise levels and reduce the growing number of noncommunicable diseases, especially obesity, diabetes, and cardiovascular disease in this population of the basic foundations of any family are a great help. Methods: 30 healthy women in the age range of 25-35 years with menstrual period and regular sleep, BMI equal to and between 25-29/9 kg / m2, without any chronic disease , available as a sample and voluntarily. The study was randomly divided into 2 groups including (control group n=10, training group n=20). high intensity circuit training was performed for 24 sessions over 8 weeks, and they were trained 3 days a week. Before and after the 8-week period, the serum levels of Irisin were measured. Results: The results showed that a period of high intensity circuit training had a significant effect on Irisin, weight loss, BMI and aerobic fitness in overweight sedentary women (P<0.05). Conclusion: It can be concluded that this exercise protocol intake have some positive effects on serum levels of Irisin in overweight sedentary women can benefit from any of these interventions to improve their physical condition and their health
Abedi B, Akhlaghi R, Saremi A. Acute Effect of Endurance Exercise on Plasma Irisin And Insulin Resistance In Obese/Over Weight Women. 2017;7(2):1887-1896 (In Persian).
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, LO JC, et al.A PGC1-[agr]-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.Nature .2012;481(7382):463-8.
Catli G, Kume T, Tuhan H, Anik A, Calan O, Bober E, et al. Relation of serum irisin level with metabolic and anthropometric parameters in obese children. Journal of Diabetes and its Complications. 2016;30(8)1560-5.
Dehghani K, Mogharnasi M, Saghebjoo M, Sarir H, Malekaneh M. The Effect of Eight Weeks of Circuit Resistance Training and Spirulina Supplementation on Plasma Levels of Irisin and Some Body Composition in Overweight and Obese Men. Armaghane danesh. 2020; 25 (3) :332-345 (In Persian).
Erichson HP.Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte. 2013;2(4);289-93.
Ghobadian S, Kazemi F, Nazarali P. The effects of a high-intensity interval training on plasma levels of orexin-A and insulin resistance in overweight women. Journal of School of Public Health & Institute of Public Health Research. 2019;17(1) (In Persian).
Gmiat A, Ziemann E, Micielska K, Flis D.J, Kozlowska M, Smaruj M, et al. the impact of a single bout of high intensity circuit training on myokines concentrations and different age. 2017;179:290-297.
Hofmann T, Elbelt U, Ahnis A, Kobelt P, Rose M, Stengel A. Irisin levels are not affected by physical activity in patient with anorexia nervousa. 2014;4:202.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BF, et al. FNDC5 and irisin in human: Ⅰ.predictors of circulating concentrations in serum and plasma and Ⅱ. mRNA expression and circulating concentration in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BF, et al. FNDC5 and irisin in human: Ⅰ.predictors of circulating concentrations in serum and plasma and Ⅱ. mRNA expression and circulating concentration in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38.
Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015;100:453-7.
Jafari A. Effects of Sucrose Consumption after High-Intensity Interval Training (HIIT) on the Plasma Levels of Irisin, Insulin, and Glucose in Overweight and Obese Women. Iranian Journal of Endocrinology and Metabolism. 2020 Dec 10;22(4):328-36 (In Persian).
Klika B, Jordan C. High-intensity circuit training using body weight. ACSMs Health & Fitness Journal. 2013; 17(3):8-13.
Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al. Effects of obesity, diabetes and exercise on FNDC5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies, the journal pgysiology. 2014;592(5):1091-1107.
Malekzadeh R, Mohamadnejad M, Merat S, Pourshams A, Etemadi A. Obesity pandemic: an Iranian perspective. Archives of Iranian Medicine. 2005;8(1):1-7 (In Persian).
Martinus R, Corban R, Wackerhage H, Atkins S, Singh J. Effect of psychological intervention on exercise adherence in type 2 diabetic subjects. Ann N Y Acad Sci 2006; 1084:350-60.
Norheim F, Mikal T, Marit H, Holen T, Kielland A, Stadheim K, et al. the effect of acute and chronic exercise on PGC-1α, Irisin and browning of subcutaneous adipose tussue in human. FEBS journal . 2014;281:739-49.
Ostrowski K, Schjerling P, Pedersen BK. Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur J Appl physiol 2000;83(6):512-5.
Pewdersen BK, Febbraio MA, Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature reviews Endocrinology.2012;8(8):457-65.
Poston WS, Foreyt JP. Successful management of the obese patient. American family physician. 2000 Jun 15;61(12):3615-22.
Ramezankhani A, Sori R. The Effect of 16 Weeks of Low Calorie Diet on Irisin Serum Levels and Insulin Resistance Index in Obese Sedentary Women. Journal of Food Technology and Nutrition. 2017 Mar 21;14(2):99-106 (In Persian)
Rostami Hashjin Z, Amirsasan R, Nikoukheslat S, Sari-Sarraf V. Effect of six weeks high intensity interval training with turmeric supplementation on irisin and UCP1 in obese females. Metabolism and Exercise. 2018 Nov 22;8(2):109-21 (In Persian).
Salimi Avansar M, Hedayatmanesh Z. The Effect of Twelve Weeks Combined Training (Aerobic + Resistance) on the Irisine and Insulin Resistance in Obese Sedentary Women. 2017;16(4):443-453 (In Persian).
Sari-Sarraf V, Amirsasan R, Halalkhor F. Effect of concurrent training and flaxseed supplementation on insulin indicators and body composition in overweight women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;21(8):9-21.
Tolson KP, Garcia C, Delgado I, Marooki N, Kauffman AS. Metabolism and energy expenditure, but not feeding or glucose tolerance, are impaired in young Kiss1r KO female mice. Endocrinology 2016;157:4192–4199.
Vahdat H, Mombini H, Eslami Farsani M, Ab Abzadeh S, Barzegar H. Effect of High-Intensity Interval Training (HIIT) on the Levels of Irisin and Interleukin-10 in Overweight Men. Qom Univ Med Sci J. 2018; 12 (2) :35-44 (In Persian).
Wrann CD. FNDC5/Irisin-their role in the nerbous system and as a mediator for beneficial effects of exercise on the brain, Brain plasticity. 2015;1)1(:55-61.
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell metabolism. 2011;13(2):160-9.
Yousefipoor P, Tadibi V, Behpoor N, Parnow A, Delbari E, Rashidi S. The effect of 8-week aerobic and concurrent (aerobic-resistance) exercise training on serum il-6 levels and insulin resistance in type 2 diabetic patients. SSU J 2013; 21:619-31 (In Persian).
Zaeimifard E, Arshadi S, Sohaily S, Banaeifar A. The effect of aerobic exercise on indicators of preptin, irizine and insulin resistance in obese women. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES),[online]. 2020 Jan 1;27(2):70-9(In Persian).
Zamanpour L, Banitalebi E, Amirhosseini SE. The effect of sprint training and combined aerobic and strength training on some inflammatory markers and insulin resistance in women with diabetes mellitus (T2dm). Iran J Diabetes Metab 2016; 15:300-11 (In Persian).
_||_Abedi B, Akhlaghi R, Saremi A. Acute Effect of Endurance Exercise on Plasma Irisin And Insulin Resistance In Obese/Over Weight Women. 2017;7(2):1887-1896 (In Persian).
Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, LO JC, et al.A PGC1-[agr]-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.Nature .2012;481(7382):463-8.
Catli G, Kume T, Tuhan H, Anik A, Calan O, Bober E, et al. Relation of serum irisin level with metabolic and anthropometric parameters in obese children. Journal of Diabetes and its Complications. 2016;30(8)1560-5.
Dehghani K, Mogharnasi M, Saghebjoo M, Sarir H, Malekaneh M. The Effect of Eight Weeks of Circuit Resistance Training and Spirulina Supplementation on Plasma Levels of Irisin and Some Body Composition in Overweight and Obese Men. Armaghane danesh. 2020; 25 (3) :332-345 (In Persian).
Erichson HP.Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte. 2013;2(4);289-93.
Ghobadian S, Kazemi F, Nazarali P. The effects of a high-intensity interval training on plasma levels of orexin-A and insulin resistance in overweight women. Journal of School of Public Health & Institute of Public Health Research. 2019;17(1) (In Persian).
Gmiat A, Ziemann E, Micielska K, Flis D.J, Kozlowska M, Smaruj M, et al. the impact of a single bout of high intensity circuit training on myokines concentrations and different age. 2017;179:290-297.
Hofmann T, Elbelt U, Ahnis A, Kobelt P, Rose M, Stengel A. Irisin levels are not affected by physical activity in patient with anorexia nervousa. 2014;4:202.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BF, et al. FNDC5 and irisin in human: Ⅰ.predictors of circulating concentrations in serum and plasma and Ⅱ. mRNA expression and circulating concentration in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38.
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BF, et al. FNDC5 and irisin in human: Ⅰ.predictors of circulating concentrations in serum and plasma and Ⅱ. mRNA expression and circulating concentration in response to weight loss and exercise. Metabolism. 2012;61(12):1725-38.
Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 2015;100:453-7.
Jafari A. Effects of Sucrose Consumption after High-Intensity Interval Training (HIIT) on the Plasma Levels of Irisin, Insulin, and Glucose in Overweight and Obese Women. Iranian Journal of Endocrinology and Metabolism. 2020 Dec 10;22(4):328-36 (In Persian).
Klika B, Jordan C. High-intensity circuit training using body weight. ACSMs Health & Fitness Journal. 2013; 17(3):8-13.
Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, et al. Effects of obesity, diabetes and exercise on FNDC5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies, the journal pgysiology. 2014;592(5):1091-1107.
Malekzadeh R, Mohamadnejad M, Merat S, Pourshams A, Etemadi A. Obesity pandemic: an Iranian perspective. Archives of Iranian Medicine. 2005;8(1):1-7 (In Persian).
Martinus R, Corban R, Wackerhage H, Atkins S, Singh J. Effect of psychological intervention on exercise adherence in type 2 diabetic subjects. Ann N Y Acad Sci 2006; 1084:350-60.
Norheim F, Mikal T, Marit H, Holen T, Kielland A, Stadheim K, et al. the effect of acute and chronic exercise on PGC-1α, Irisin and browning of subcutaneous adipose tussue in human. FEBS journal . 2014;281:739-49.
Ostrowski K, Schjerling P, Pedersen BK. Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur J Appl physiol 2000;83(6):512-5.
Pewdersen BK, Febbraio MA, Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature reviews Endocrinology.2012;8(8):457-65.
Poston WS, Foreyt JP. Successful management of the obese patient. American family physician. 2000 Jun 15;61(12):3615-22.
Ramezankhani A, Sori R. The Effect of 16 Weeks of Low Calorie Diet on Irisin Serum Levels and Insulin Resistance Index in Obese Sedentary Women. Journal of Food Technology and Nutrition. 2017 Mar 21;14(2):99-106 (In Persian)
Rostami Hashjin Z, Amirsasan R, Nikoukheslat S, Sari-Sarraf V. Effect of six weeks high intensity interval training with turmeric supplementation on irisin and UCP1 in obese females. Metabolism and Exercise. 2018 Nov 22;8(2):109-21 (In Persian).
Salimi Avansar M, Hedayatmanesh Z. The Effect of Twelve Weeks Combined Training (Aerobic + Resistance) on the Irisine and Insulin Resistance in Obese Sedentary Women. 2017;16(4):443-453 (In Persian).
Sari-Sarraf V, Amirsasan R, Halalkhor F. Effect of concurrent training and flaxseed supplementation on insulin indicators and body composition in overweight women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2018;21(8):9-21.
Tolson KP, Garcia C, Delgado I, Marooki N, Kauffman AS. Metabolism and energy expenditure, but not feeding or glucose tolerance, are impaired in young Kiss1r KO female mice. Endocrinology 2016;157:4192–4199.
Vahdat H, Mombini H, Eslami Farsani M, Ab Abzadeh S, Barzegar H. Effect of High-Intensity Interval Training (HIIT) on the Levels of Irisin and Interleukin-10 in Overweight Men. Qom Univ Med Sci J. 2018; 12 (2) :35-44 (In Persian).
Wrann CD. FNDC5/Irisin-their role in the nerbous system and as a mediator for beneficial effects of exercise on the brain, Brain plasticity. 2015;1)1(:55-61.
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell metabolism. 2011;13(2):160-9.
Yousefipoor P, Tadibi V, Behpoor N, Parnow A, Delbari E, Rashidi S. The effect of 8-week aerobic and concurrent (aerobic-resistance) exercise training on serum il-6 levels and insulin resistance in type 2 diabetic patients. SSU J 2013; 21:619-31 (In Persian).
Zaeimifard E, Arshadi S, Sohaily S, Banaeifar A. The effect of aerobic exercise on indicators of preptin, irizine and insulin resistance in obese women. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES),[online]. 2020 Jan 1;27(2):70-9(In Persian).
Zamanpour L, Banitalebi E, Amirhosseini SE. The effect of sprint training and combined aerobic and strength training on some inflammatory markers and insulin resistance in women with diabetes mellitus (T2dm). Iran J Diabetes Metab 2016; 15:300-11 (In Persian).