The effect of continuous aerobic exercise on the expression of UCP1 and PGC1a genes in brown adipose tissue in obese male rats.
Subject Areas : Physical Activity and Health
Sarvenaz Ali Askari
1
(
دانشگاه آزاد واحد تهران مرکز
)
محمد علی آذربایجانی
2
(
استاد گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی، دانشگاه آزاد اسلامی واحد تهران مرکز، تهران، ایران
)
سیروان آتشک
3
(
گروه تربیت بدنی و علوم ورزشی، دانشگاه آزاد اسلامی، واحد مهاباد مهاباد، ایران.
)
maghsoud peeri
4
(
Department of Exercise Physiology, Islamic Azad University, Central Tehran Branch, Tehran, Iran
)
Saleh Rahmati
5
(
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.
)
Keywords: Mitochondrial biogenesis, thermogenesis, aerobic exercise,
Abstract :
Brown adipose tissue plays a very important role in the pathogenesis of obesity. However, the effect of aerobic exercises on this tissue has received less attention. Based on this, the aim of the present study was to determine the effect of continuous aerobic exercise on the expression of UCP1 and PGC1a genes in brown adipose tissue in obese male rats. In an experimental study, 18 male rats were selected as subjects and randomly divided into three groups: control-fed with normal food, control-fed with high-fat food, and fed with high-fat diet and continuous aerobic exercise. The groups fed with high-fat diet received high-fat diet for eight weeks. Continuous aerobic exercise also included four weeks of running on a rodent treadmill. The expression of UCP1 and PGC1a genes in brown adipose tissue was measured by Real Time PCR method. The results showed that feeding with high-fat diet caused a significant decrease in the expression of UCP1 (P=0.002) and PGC1a (P=0.001) genes in brown adipose tissue. Continuous aerobic exercise increased the expression of UCP1 (P=0.040) and PGC1a (P=0.040) genes in brown fat tissue. Based on the findings of this study, it can be concluded that continuous aerobic exercise reduces the metabolic side effects of eating high-fat diet by increasing the expression of mitochondrial biogenesis and thermogenesis of brown adipose tissue. Therefore, it is recommended to perform these exercises while eating high-fat diet.
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