Evaluation of current Hemoglobinopathies in iran
Subject Areas : Large Animal Diseases
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Abstract :
Abstract: The genetic disorders of hemoglobin, the most common monogenic diseases, occur at some of their highest frequencies in the developing countries including Iran. Hemoglobinopathies include structural variants of hemoglobin (Hb S, Hb C, HbE…) and thalassemia's which inherited defects in the globin chains synthesis are. Hemoglobin disorders are fairly common in Iran estimated that 0.5 – 1 % of the Iranian population carries the genes for Hb abnormalities such as D, S, G and E. To date, many studies have been conducted in Iran and prevalence rates for hemoglobinopathies have been assessed. The present survey was undertaken to assess the current prevalence and types of hemoglobinopathies in a regional population of Iran with regard to molecular study. Different mutation in α, β globin's genes causes. There is variation in the prevalence of hemoglobinopathies in different regions and ethnic groups of the country. Based on the result of study, the β-chain variants of hemoglobin S are more prevalent in southwestern Iran. Also, α-chain variants of Hb Q-Iran and Hb Setif are prevalent in western Iran. The molecular basis and clinical severity of thalassemia's are extremely heterogeneous among Iranians due to the presence of multiethnic groups in the country. The prevalence rate of β-thalassemia gene in the southern and northern provinces of Iran was higher than the average national rate. The clinical diversity of Hb H disease (similar genotypes with different phenotypes) has been reported in Iran. In this article, we reviewed more than 20 published papers on hemoglobinopathies in Iran.
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