Alteration of chronic pain sensation due to the blocking of the cholinergic system

Subject Areas : clinical veterinary science

R. Hajikhani ¹ , M.R Rahimnejad ²

1 - Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Iran
2 - Department of Basic Science, Faculty of Veterinary Medicine, Islamic Azad University, Karaj Branch, Iran.

Received: 2016-11-02 Accepted : 2016-11-02 Published : 2010-09-23

Keywords: atropine, chronic pain, anticholinergic,

Abstract :

Numerous neurotransmitters are responsible for in sensation and process of pain in the nervous system. But therole of cholinergic system has not been properly studied. Thus in order to study the cholinergic antagonistic effectsin pain, the effect of atropine (10 mg/ kg/IP) on chronic pain, has been studied on male and female mice byintraplantar injection of 2.5% formalin (Formalin test).The results obtained indicated that male mice treated by atropine had a higher pain threshold in comparison tothe reference group. In the meantime, this test in the female reference group showed a significant increase in thethreshold of pain. No Significant difference has been shown between male and female experimental groups.The findings of this research indicated that anticholinergic compounds, such as atropine can reduce chronic pain.