Induction of estrus in anestrous Terrier by a combination of cabergoline and HCG
Subject Areas : clinical veterinary scienceA. Rastegarnia, 1 , M. Fatehfar 2 , ارسلان Amirfallah 3 , , N. Moradi 4
1 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch,
Islamic Azad University, Urmia , Iran
2 - Graduated from the Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad
University, Urmia, Iran
3 - Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch,
Islamic Azad University, Urmia , Iran
4 - Graduated from the Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad
University, Urmia, Iran
Keywords: Estrus, HCG, bitch, cabergoline,
Abstract :
In this experiment, the effect of oral administration of cabergoline, an anti-prolactin drug on induction of fertileestrus in bitches was investigated. For this purpose, fourteen bitches from terrier breeds were used in the studyat their already determined periods of anestrous. Four dogs formed the control group, while 10 bitches weretreatment group. All treatment females were administered with recommended doses (5µg/day) of cabergolineformulation marketed for use in women. An aqueous solution of cabergoline (casber, Pharmacia, Italy) was orallyadministered until 2 days after the onset of proestrus or for a maximum of 41 days. The dogs with signs of proestrus(8/10) following the treatment were assigned into two subgroups. Five hundred IU of HCG was intramuscularlyadministered to four of these dogs on days 1 and 3 of estrus. The remaining 4 dogs were not treated with HCG.Blood samples were taken once from all females during the frst days of treatment and then every other dayduring the beginning the behavioral estrus to measure progesterone concentrations. Induced estrus rates and meantreatment and proestrus durations of dogs in treatment were compared. In the treatment proestrus was inducedbetween days 21– 41 (mean: 29±6.5 days), in the ratio of 80.0 (p < 0.05). The duration of proestrus and oestruswas found to be 8.1 ±1.9 (range, 6 to 11).The duration of estrus in the HCG (+) and HCG (-) subgroups were found to be 10.1 ±1.8 (range9 to 11) and 14 ±2.5 (range, 8 to 12) days, respectively. The conception rate in relation to the number of bitches responding to theestrus induction treatment was similar, 50% (2 out of 4) and mean number of offspring in the HCG(+) and HCG(-)subgroups were found to be 3.5 ± 0.6 and 4 ± 1.4 , respectively (p > 0.05). In control group, all the animals did notshow estrus behavior or pregnancy at the same period.It has been concluded from this study that normal and fertile estrus can be induced more economically in bitchesduring different stages of anestrous using cabergoline formulation marketed for use in women, and HCG injectionson days 1 and 3 of the estrus induced by this method had no positive effects on the pregnancy rates.