Evaluation of the effcacy of chicken infectious anemia Vaccine in broiler breeder flock based on variation and persistency in anti-CAV antibodies titers
Subject Areas : clinical veterinary scienceپیام Haghighi-Khoshkhoo 1 , مهرداد Tashakori 2 , علیرضا Bahonar 3 , گیتا Akbari-Azad 4
1 - Department of Clinical sciences, Faculty of Veterinary Medicine, Islamic Azad University,
Karaj branch, Karaj, Iran
2 - Graduated from Faculty of Veterinary Medicine, Islamic Azad
University, Karaj branch, Karaj, Iran.
3 - Department of Food Hygiene & Quality Control, Faculty of Veterinary Medicine,
University of Tehran, Tehran, Iran.
4 - Department of Clinical sciences, Faculty of Veterinary Medicine, Islamic Azad University,
Karaj branch, Karaj, Iran
Keywords: Elisa, Live vaccine, Chicken infectious anemia, CIA, Broiler breeder flock,
Abstract :
Chicken Infectious Anemia (CIA), a disease of young chickens, can be prevented by immunization of breedingflocks with live vaccines. The objective of the present work was to perform the effcacy of one attenuated live vaccineNobilis CAV P4 (Intervet Co., Netherland) based on induction of persistent antibodies in broiler breeder and theirprogenies compared to unvaccinated broiler breeder flock. The vaccine administrated to Ross 308 broiler breederflocks at 6-week old via S.C. rout. A total of 352 serum samples were collected from vaccinated and unvaccinatedbreeder flocks from 6 to 33 week old (5, 12, 16, 20 and 28 weeks after vaccination) and twice in their progeny flocksat one- day old. Sera were analyzed by indirect ELISA (Synbiotics Corporation, USA) and data were compared statistically between the two groups by t-test. The results showed natural infection of CIA virus in unvaccinated breederflock and not only the mean titer was higher but also thecoeffcient variant (CV%) was lower than vaccinated breederflock signifcantly (P<0.05). But the CV% in progeny of vaccinated breeder flock was lower than the CV% in progeny of unvaccinated breeder flock. Also, there was anti-CAV antibody negative in hens and progenies in unvaccinatedbreeder flock, so these hens potentially can transmit the virus vertically. All breeders from vaccinated flock were positive serologically. It seemed that vaccination could be an effcient rout for eliminating susceptible birds, decreasingvariation in anti-CAV antibodies titers and induction persistent antibody titer. However more experiments need to becarried out to defne if vaccination really is desirable.