Rapid cataract induction by Sodium Selenite in rabbit
Subject Areas : clinical veterinary scienceVoria Tohidi 1 , Saeed Azimpour 2
1 - Department of Clinical Science, Veterinary Faculty, Urmia Branch, Islamic Azad University, Urmia, Iran
2 - Department of Clinical Science, Veterinary Faculty, Babol Branch, Islamic Azad University, Babol, Iran
Keywords: Rabbit, Sodium selenite, Cataract,
Abstract :
For the clear and precise vision, it is necessary that the light way in your eyes to be transparent and the cornea and lens focus light on the retina correctly. In cataract, less light passes through the lens as a result of blurring of the lens. The ability of lens adaptation reduces with time. As a result, the sensitivity of subtraction will go away. The aim of this study was to try to make a rapid cataract in rabbits by injection of sodium selenite. For this purpose, 12 rabbits were kept for two weeks prior to injection for assuring of being clinically healthy and their eyes were examined for being free of cataract and other disorders by means of ophthalmoscopy, slit lamp biomicroscopy and ultrasonography. Rapid cataract was induced by subcutaneous injection of 1 mg/kg bw of sodium selenite and repeated two more times with 2 days interval (3 mg/kg bw totally). All rabbits were examined by ophthalmoscopy and B-mode ultrasonography daily and slit lamp biomicroscopy with three days interval until cataract was developed at day 9. At this time, Linear Cortical and posterior subcapsular cataract were observed in all rabbits. 4 rabbits were euthanized at day 23 for histological examination of the lenses and Induction of cataract was confirmed histology.
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