Effects of selenium nanoparticles on stearoyl-CoA desaturase gene transcription rate in adipose tissue of prepubertal male lambs
Subject Areas :
Veterinary Clinical Pathology
Hamid Esmaeeli Najafabadi
1
,
Gholamali Kojouri
2
,
Ali mohammad Ahadi
3
1 - PhD Student, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
2 - Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
3 - Associate Professor, Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
Received: 2019-05-13
Accepted : 2020-06-29
Published : 2020-04-20
Keywords:
lamb,
selenium nanoparticles,
Stearoyl CoA enzyme,
Tail fat tissue,
Abstract :
Selenium plays a crucial role in the formation of selenoprotein and hormones. The stearoyl-CoA desaturase enzyme (SCD) is present in many tissues of the body and its activity leads to the formation of a single-stranded fatty acid from saturated fatty acids. The present study was carried out on fat tail weaning male lambs to evaluate the effect of oral selenium nanoparticles administration on tail fat transcription rate of stearoyl-CoA desaturase enzyme. For this purpose, 14 male lambs were selected at weaning time and divided into three groups: treatment 1 (5 lambs), treatment 2 (5 lambs) and control (4 lambs). Selenium nanoparticles were administered for 20 consecutive days at a dose of 0.05 and 0.1 mg/kg to treatment groups 1 and 2, respectively and distilled water to the control ones. Tail fat tissue samples were collected at days 0, 20 and 30 via core biopsy needle. Transcription rate of stearoyl-CoA desaturase (SCD) enzyme gene was determined by RT-PCR method and data were analyzed statistically using ANOVA test at the level of p < /em>
References:
Ahmadipour, B., Hassanpour, H., Asadi, E., Khajali, F., Rafiei, F. and Khajali, F. (2015). Kelussia odoratissima Mozzaf-A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude. Journal of Ethnopharmacology, 159(15): 49-54.
Barber, M.C., Ward, R.J., Richards, S.E., Salter, A.M., Buttery, P.J., Vernon, R.G., et al. (2000). Ovine adipose tissue monounsaturated fat content is correlated to depot-specific expression of the stearoyl-CoA desaturase gene. Journal of Animal Sciences, 78(1): 62-68.
Battin, E.E. and Brumaghim, J.L. (2009). Antioxidant activity of sulfur and selenium: are view of reactive oxygen species scavenging, glutathione peroxidase and metal binding antioxidant mechanisms. Cell Biochemistry and Biophysics, 55(1): 1-23.
Beheshti, N., Ajami, M., Kamal, Z., Abdollahi, M. and Davoodi, S.H. (2016). The effect of dietary conjugated linoleic acid and assessment of anti-oxidant factors on the risk of developing colorectal cancer. Teb va Tazkiye, 25(4): 169-182. ]In Persian[
Ben-David, U., Gan, Q.F., Golan-Lev, T., Arora, P., Yanuka, O., Oren, Y.S., et al. (2013). Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell, 12(2): 167-79.
Chahardoli, A., Kojouri, G.A. and Ahadi, A.M. (2017). Effect of oral administration of selenium nanoparticles on the Insulin-like Growth Factor1 (IGF-1) in prepubertal male lambs. Iranian Journal of Veterinary Clinical Sciences, 11(1): 49-56. ]In Persian[
Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell, 84(3): 491-495.
Christie, W.W. (1981). The composition structure and function of lipids in the tissues of ruminant animals. Lipid Metabolism in Ruminant Animals, 1st ed., Pergamon; Elsevier Ltd, pp: 95-191.
Daniel, Z.C.T.R., Wynn, R.J., Salter, A.M. and Buttery, P.J. (2004). Linoleic acid content of sheep tissues: The role of stearoyl-CoA desaturase differing effects of forage and concentrate diets on the oleic acid and conjugated. Journal of Animal Sciences, 82(3): 747-758.
Esmaeili Shahmirzadi, F. and Ghavamzadeh, S. (2015). Conjugated linoleic acid supplementation, a new approach against obesity in infants and childhoods. International congress of maternal and childhood obesity, Urmia, Iran. ]In Persian[
Fain, J.N., Madan, A.K., Hiler, M.L., Cheema, P. and Bahouth, S.W. (2004). Comparison of the release of adipokines by adipose tissue, adipose tissue matrix and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology, 145(5): 2273-2282.
Flier, J.S., Cook, K.S., Usher, P. and Spiegelman, B.M. (1987). Severely impaired adipsin expression in genetic and acquired obesity. Sciences, 237(4813): 405-408.
Friedman, J.M. and Halaas, J.L. (1998). Leptin and the regulation of body weight in mammals. Nature, 395(6704): 763-770.
Griinari, J.M., Corl, B.A., Lacy, S.H., Chouinard, P.Y., Nurmela, K.V.V. and Bauman, D.E. (2000). Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by 9 -desaturase. Journal of Nutrition, 130(9): 2285-2291.
Ide, Y., Waki, M., Hayasaka, T., Nishio, T., Morita, Y., Tanaka, H., et al. (2013). Human breast cancer tissues contain abundant phosphatidylcholine with high stearoyl-CoA desaturase-1 expression. PLOS ONE, 8(4): 61204.
Kam, N.W.S. and Dai, H. (2005). Carbon nanotubes as intracellular protein transporters: generality and biological functionality. Journal of American Chemistry Society, 127(16): 6021-6026.
Kamyab, A.R. (2010). Polymerase chain reaction technique using SYBR green I in the diagnosis of Down syndrome. Medical Science, 19(2): 93-96.
Kojouri, G.A. (2019). Metabolic Diseases of Large Animals. First ed., Shahrekord; Shahrekord University Publication, pp: 143, 242. [In Persian]
Kojouri, G.A., Jahanabadi, S. Shakibaie, M. Ahadi, A. and Shahverdi, A.R. (2012). Effect of selenium supplementation with sodium selenite and selenium nanoparticles on iron homeostasis and transferrin gene expression in sheep: a preliminary study. Research in Veterinary Science 93(1): 275-278.
Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I., et al. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379(6566): 632-635.
Mashek, D.G., Bertics, S.J. and Grummer, R.R. (2005). Effects of intravenous triacylglycerol emulsions on hepatic metabolism and blood metabolites in fasted dairy cows. Journal of Dairy Sciences, 88(1): 100-109.
Margetic, S., Gazzola, C., Pegg, G.G. and Hill, R.A. (2002). Leptin: a review of its peripheral actions and interactions. International Journal of Obesity and Related Metabolic Disorders, 26(11): 1407-1433.
Mohammadzadeh, F., Mosayebi, G., Montazeri, V., Darabi, M., Fayezi, S., Shaaker, M., et al. (2014). Fatty acid composition of tissue cultured breast carcinoma and the effect of stearoyl-coa desaturase 1 inhibition. Journal of Breast Cancer, 17(2): 42-136.
Rahimi, Y., Mehdizadeh, A., Nozad Charoudeh, H., Nouri, M., Valaei, K., Fayezi, S., et al. (2015). Hepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activity. Development Growth and Differentiation, 57(9): 574-667.
Rahman, S.M., Dobrzyn, A., Lee, S.H., Dobrzyn, P., Miyazaki, M. and Ntambi, J.M. (2005). Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. American Journal of Physiology and Endocrinology Metabolism288(2): 381-387.
Rayman DPhil, M.P. (2000). The importance of selenium to human health. The Lancet, 356(9225): 233-241.
Ward, M., Newille, T., Reed, J., Tallor, J., Hallford, D., Soto-Navarro, S., et al. (2008). Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs. Journal of Animal Sciences, 86(5): 1254-1262.
Ward, R.J., Travers, M.T., Richards, S.E., Vernon, R.G, Salter, A.M., Buttery, P.J., et al. (1998). Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome. Biochimical et Biophysical Acta (BBA), 1391(2): 145-156.
Yilmaz, A., Davis, M. and Simmen, R. (1999). Reproductive performance of bulls divergently selected on the basis of blood serum insulin-like growth factor I concentration. Journal of Animal Sciences, 77(4): 835-839.
Zhang, L., Pan, Y., Qin, G., Chen, L., Chatterjee, T.K., Weintraub, N.L., et al. (2014). Inhibition of stearoyl-CoA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle, 13(5): 71-762.
_||_
Ahmadipour, B., Hassanpour, H., Asadi, E., Khajali, F., Rafiei, F. and Khajali, F. (2015). Kelussia odoratissima Mozzaf-A promising medicinal herb to prevent pulmonary hypertension in broiler chickens reared at high altitude. Journal of Ethnopharmacology, 159(15): 49-54.
Barber, M.C., Ward, R.J., Richards, S.E., Salter, A.M., Buttery, P.J., Vernon, R.G., et al. (2000). Ovine adipose tissue monounsaturated fat content is correlated to depot-specific expression of the stearoyl-CoA desaturase gene. Journal of Animal Sciences, 78(1): 62-68.
Battin, E.E. and Brumaghim, J.L. (2009). Antioxidant activity of sulfur and selenium: are view of reactive oxygen species scavenging, glutathione peroxidase and metal binding antioxidant mechanisms. Cell Biochemistry and Biophysics, 55(1): 1-23.
Beheshti, N., Ajami, M., Kamal, Z., Abdollahi, M. and Davoodi, S.H. (2016). The effect of dietary conjugated linoleic acid and assessment of anti-oxidant factors on the risk of developing colorectal cancer. Teb va Tazkiye, 25(4): 169-182. ]In Persian[
Ben-David, U., Gan, Q.F., Golan-Lev, T., Arora, P., Yanuka, O., Oren, Y.S., et al. (2013). Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell, 12(2): 167-79.
Chahardoli, A., Kojouri, G.A. and Ahadi, A.M. (2017). Effect of oral administration of selenium nanoparticles on the Insulin-like Growth Factor1 (IGF-1) in prepubertal male lambs. Iranian Journal of Veterinary Clinical Sciences, 11(1): 49-56. ]In Persian[
Chen, H., Charlat, O., Tartaglia, L.A., Woolf, E.A., Weng, X., Ellis, S.J., et al. (1996). Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell, 84(3): 491-495.
Christie, W.W. (1981). The composition structure and function of lipids in the tissues of ruminant animals. Lipid Metabolism in Ruminant Animals, 1st ed., Pergamon; Elsevier Ltd, pp: 95-191.
Daniel, Z.C.T.R., Wynn, R.J., Salter, A.M. and Buttery, P.J. (2004). Linoleic acid content of sheep tissues: The role of stearoyl-CoA desaturase differing effects of forage and concentrate diets on the oleic acid and conjugated. Journal of Animal Sciences, 82(3): 747-758.
Esmaeili Shahmirzadi, F. and Ghavamzadeh, S. (2015). Conjugated linoleic acid supplementation, a new approach against obesity in infants and childhoods. International congress of maternal and childhood obesity, Urmia, Iran. ]In Persian[
Fain, J.N., Madan, A.K., Hiler, M.L., Cheema, P. and Bahouth, S.W. (2004). Comparison of the release of adipokines by adipose tissue, adipose tissue matrix and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology, 145(5): 2273-2282.
Flier, J.S., Cook, K.S., Usher, P. and Spiegelman, B.M. (1987). Severely impaired adipsin expression in genetic and acquired obesity. Sciences, 237(4813): 405-408.
Friedman, J.M. and Halaas, J.L. (1998). Leptin and the regulation of body weight in mammals. Nature, 395(6704): 763-770.
Griinari, J.M., Corl, B.A., Lacy, S.H., Chouinard, P.Y., Nurmela, K.V.V. and Bauman, D.E. (2000). Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by 9 -desaturase. Journal of Nutrition, 130(9): 2285-2291.
Ide, Y., Waki, M., Hayasaka, T., Nishio, T., Morita, Y., Tanaka, H., et al. (2013). Human breast cancer tissues contain abundant phosphatidylcholine with high stearoyl-CoA desaturase-1 expression. PLOS ONE, 8(4): 61204.
Kam, N.W.S. and Dai, H. (2005). Carbon nanotubes as intracellular protein transporters: generality and biological functionality. Journal of American Chemistry Society, 127(16): 6021-6026.
Kamyab, A.R. (2010). Polymerase chain reaction technique using SYBR green I in the diagnosis of Down syndrome. Medical Science, 19(2): 93-96.
Kojouri, G.A. (2019). Metabolic Diseases of Large Animals. First ed., Shahrekord; Shahrekord University Publication, pp: 143, 242. [In Persian]
Kojouri, G.A., Jahanabadi, S. Shakibaie, M. Ahadi, A. and Shahverdi, A.R. (2012). Effect of selenium supplementation with sodium selenite and selenium nanoparticles on iron homeostasis and transferrin gene expression in sheep: a preliminary study. Research in Veterinary Science 93(1): 275-278.
Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I., et al. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379(6566): 632-635.
Mashek, D.G., Bertics, S.J. and Grummer, R.R. (2005). Effects of intravenous triacylglycerol emulsions on hepatic metabolism and blood metabolites in fasted dairy cows. Journal of Dairy Sciences, 88(1): 100-109.
Margetic, S., Gazzola, C., Pegg, G.G. and Hill, R.A. (2002). Leptin: a review of its peripheral actions and interactions. International Journal of Obesity and Related Metabolic Disorders, 26(11): 1407-1433.
Mohammadzadeh, F., Mosayebi, G., Montazeri, V., Darabi, M., Fayezi, S., Shaaker, M., et al. (2014). Fatty acid composition of tissue cultured breast carcinoma and the effect of stearoyl-coa desaturase 1 inhibition. Journal of Breast Cancer, 17(2): 42-136.
Rahimi, Y., Mehdizadeh, A., Nozad Charoudeh, H., Nouri, M., Valaei, K., Fayezi, S., et al. (2015). Hepatocyte differentiation of human induced pluripotent stem cells is modulated by stearoyl-CoA desaturase 1 activity. Development Growth and Differentiation, 57(9): 574-667.
Rahman, S.M., Dobrzyn, A., Lee, S.H., Dobrzyn, P., Miyazaki, M. and Ntambi, J.M. (2005). Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. American Journal of Physiology and Endocrinology Metabolism288(2): 381-387.
Rayman DPhil, M.P. (2000). The importance of selenium to human health. The Lancet, 356(9225): 233-241.
Ward, M., Newille, T., Reed, J., Tallor, J., Hallford, D., Soto-Navarro, S., et al. (2008). Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs. Journal of Animal Sciences, 86(5): 1254-1262.
Ward, R.J., Travers, M.T., Richards, S.E., Vernon, R.G, Salter, A.M., Buttery, P.J., et al. (1998). Stearoyl-CoA desaturase mRNA is transcribed from a single gene in the ovine genome. Biochimical et Biophysical Acta (BBA), 1391(2): 145-156.
Yilmaz, A., Davis, M. and Simmen, R. (1999). Reproductive performance of bulls divergently selected on the basis of blood serum insulin-like growth factor I concentration. Journal of Animal Sciences, 77(4): 835-839.
Zhang, L., Pan, Y., Qin, G., Chen, L., Chatterjee, T.K., Weintraub, N.L., et al. (2014). Inhibition of stearoyl-CoA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle, 13(5): 71-762.
