The effect of dietary supplement of celmanax® prebiotic on gill and liver histology in Rainbow trout during the growing period and experimental challenge with yersiniosis
Subject Areas :
Veterinary Clinical Pathology
amin Khodadadi
1
,
Adel Haghighi
2
,
Hasan Malekinejad
3
,
Amir Tukmechi
4
,
Mohamad Afsharnasab
5
1 - Department of Health, Aquatic Animal Health and Disease, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, IRAN
2 - Associate Professor, Department of Pathology, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3 - Professor, Department of pharmacology and toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran
Professor, Food and beverages safety Research center, Urmia University of Medical Sciences, Urmia, Iran
4 - Associate Professor, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
5 - Assistant Professor, Department of Health, Aquatic Animal Health and Disease, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, IRAN
Received: 2017-11-29
Accepted : 2018-11-17
Published : 2018-12-22
Keywords:
Rainbow trout,
liver,
prebiotics,
Gill,
Yersiniosis,
Abstract :
Currently, global use of prebiotic compounds has increased considerably. This study aims to analyse the effect of complementing the rations of rainbow trout with different concentrations of Celmanax® prebiotic, which contains Saccharomyces cerevisia associated compounds with Mannan-oligosaccharide on gill and liver histology during the growing period and experimental challenge with yersiniosis. Four concentration levels of prebiotic (0, 0.1, 0.5 and 1%) were mixed into fish feed pellets. The fish (with mean body weight of 19.08±1.45 gr) were fed a supplemented commercial diet for 60-days.On day 60 of the study, experimental yersiniosis was induced in all treatment groups by intraperitoneal injection of bacterial suspension. Tissue samples were taken on days 0, 30 and 60 and also after induction of experimental yersiniosis. The results showed that complementing rainbow trout rations with different concentrations of Celmanax® improved the gill and liver injuries on days 30 and 60 of the study. The best tissue effects in the growing period were observed in treatment groups which received 0.1% and 0.5% of the prebiotic respectively, and after experimental challenge with yersiniosis, the lowest lesions of liver and gill pathology were seen in the treatment group fed with 0.1% prebiotic which was significantly different (p<0.05) from all other treatments. According to the results of this study, adding Celmanax® to rainbow trout diet at 0.1% concentration improves tissue parameters during breeding period and decreases tissue lesions when faced with yersiniosis. Conflict of interest: None declared.
References:
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Custódio, M.F. (2014). The effects of mannan-oligosaccharide supplementation on the skin and gut epithelium health status of European seabass (Dicentrarchus labrax). Aquaculture and Fisheries, 14: 2-14.
Dimitroglou, A., Merrifield, D.L., Spring, P., Sweetman, J., Moate, R. and Davies, S.J. (2010). Effects of mannan oligosaccharide (MOS) supplementation on growth performance, feed utilisation, intestinal histology and gut microbiota of gilthead sea bream (Sparus aurata). Aquaculture, 300: 182-188.
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Gatesoupe, F.J. (2002). Probiotic and formaldehyde treatments of Artemia nauplii as food for larval pollack, Pollachius pollachius. Aquaculture, 212: 347-360.
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Khodadadi, A., Arabzadeah, P., Rasouli, S., Moradpoor, A. and Abediyan, A. (2014). Survey of rainbow trout moetality in cage culture farms in Hasanloo Dam, West Azerbaijan province. Journal of Veterinary Clinical Pathology, 8(3): 461-522. [In Persian]
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Merrifield, D.L., Dimitroglou, A., Foey, A., Davies, S.J., Baker, R.T.M., Bøgwald, J., et al. (2010). The current status and future focus of probiotic and prebiotic applications for salmonids. Aquaculture, 302: 1-18.
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Merrifield, D.L. and Ringø, E. (2014). Aquaculture nutrition: gut health, probiotics, and prebiotics. 1st ed., Wiley Blackwell Publishes: Electronic Formats, pp: 125-500.
Nikoskelainen, S., Ouwehand, A., Salminen, S. and Bylund, G. (2001). Protection of rainbow trout (Oncorhynchus mykiss) from furunculosis by Lactobacillus rhamnosus. Aquaculture, 198 (3-4): 229-236.
Pérez, T., Balcázar, J.L., Ruiz-Zarzuela, I., Halaihel, N., Vendrell, D., de Blas, I., et al. (2010). Host–microbiota interactions within the fish intestinal ecosystem. Mucosal Immunology, 3: 355-360.
Pérez-Sánchez, T., Ruiz-Zarzuela, I., De Blas, I. and Balcázar, J.L. (2013). Probiotics in aquaculture: a current assessment. Reviews in Aquaculture, 10: 1-10.
Rayes, N., Seehofer, D., Theruvuth, T., Schiller, R.A., Langrehr, J.M., Jonus, S., et al. (2004). Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation—a randomized, double-blind trial. American Journal of Transplantation, 5: 125-130.
Rishi, P., Kaur Mari, S., Bharrhan, S., Shukla, G. and Rupinder, T. (2009). Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. FEMS Microbiology Ecology, 69: 222-230.
Roberts, R.J. (2001). The immunology of teleost. 1st ed., UK: London, W.B. Saunders, pp: 133-150.
Sealy, W.M., Barrows, F.T., Johansen, K.A., Overturf, K., LaPatra, S.E. and Hardy, R.W. (2007). Evaluation of the ability of partially autolysed yeast and Grobiotic-A to improve disease resistance in rainbow trout. North American Journal of Aquaculture, 69: 400-406.
Staykov, Y., Spring, P. and Denev, S. (2005). Influence of dietary Bio-Mos® on growth, survival and immune status of rainbow trout (Salmo gairdneri irideus G.) and common carp (Cyprinus carpio). In: Nutritional Biotechnology in the Feed and Food Industries. 1st ed., Nottingham University Press, pp: 333-343.
Staykov, Y., Spring, P., Denev, S. and Sweetman, J. (2007). Effect of a mannan oligosaccharide on the growth performance and immune status of rainbow trout (Oncorhynchus mykiss). Aquaculture International, 15: 153-161.
Taheri Mirghaed, A., Ebrahimzadeah, S.M., Nouri Mogehi, M.H. and Agahi, N. (2014). Colour Atlas of Fish Pathology. 1st ed., Iran: Tehran, Jahad Daneshgahi Publishes, pp: 111-302.
Tukmechi, A., Rahmati Andani, H.R., Manaffar, R. and Sheikhzadeh, N. (2011). Dietary administration of beta-mercapto-ethanol treated Saccharomyces cerevisiae enhanced the growth, innate immune response and disease resistance of the rainbow trout, Oncorhynchus mykiss. Fish Shellfish Immunology, 30: 923-928.
Yadav, M. and Schorey, J.S. (2006). The β-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood, 108: 3168-3175.
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Akhlaghi, M. and Sharifi Yazdi, H. (2008). Detection and identification of virulent Yersinia ruckeri: the causative agent of enteric red mouth disease in rainbow trout (Oncorhynchus mykiss) cultured in Fars province, Iran. Iranian Journal of Veterinary Research, 9(4): 347-352.
Akhter, N., Wu, B., Memon, A.M. and Mohsin, M. (2015). Probiotics and prebiotics associated with aquaculture, a review. Fish and Shellfish Immunology, 45: 733-741.
Balcázar, J.L., De Blas, I., Ruiz-Zazuela, I., Cunningham, D., Vandrell, D. and Muzquiz, J.L. (2006). The role of probiotics in aquaculture. Veterinary Microbiology, 114: 173-186.
Balcázar, J.L., Vendrell, D., De Blas, I., Ruiz-Zarzuela, I., Muzquiz, J.L. and Gironés, O. (2008). Characterization of probiotic properties of lactic acid bacteria isolated from intestinal microbiota of fish. Aquaculture, 278: 188-191.
Bron, P.A., Van Baarlen, P. and Kleerebezem, M. (2014). Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nature Reviews Microbiology, 10: 66-78.
Custódio, M.F. (2014). The effects of mannan-oligosaccharide supplementation on the skin and gut epithelium health status of European seabass (Dicentrarchus labrax). Aquaculture and Fisheries, 14: 2-14.
Dimitroglou, A., Merrifield, D.L., Spring, P., Sweetman, J., Moate, R. and Davies, S.J. (2010). Effects of mannan oligosaccharide (MOS) supplementation on growth performance, feed utilisation, intestinal histology and gut microbiota of gilthead sea bream (Sparus aurata). Aquaculture, 300: 182-188.
El-Haroun, E.R., Goda, A. and Chowdhury, M.A.K. (2006). Effect of dietary probiotic Biogen® supplementation as a growth promoter on growth performance and feed utilization of Nile tilapia Oreochromis niloticus (L.). Aquaculture Research, 37(14): 1473-1480.
Gatesoupe, F.J. (2002). Probiotic and formaldehyde treatments of Artemia nauplii as food for larval pollack, Pollachius pollachius. Aquaculture, 212: 347-360.
Gültepe, N., Sabri Kesbic, O. and Acar, Ü. (2015). Effects of Prebiotic Mannanoligosaccharides (MOS) on Histology and Biochemical Blood Parameters of Gilthead Seabream, Sparus aurata. The Israeli Journal of Aquaculture, 67(2015): 1072-1078.
Johnson-Henry, K.C., Mitchell, D.J., Avitzur, Y., Galindo-Mata, E., Jones, N.L. and Sherman, P.M. (2004). Probiotics Reduce Bacterial Colonization and Gastric Inflammation in H. pylori-Infected Mice. Digestive Diseases and Sciences, 49: 1095-1102.
Kaur, T. and Bansal, M.P. (2006). Selenium enrichment and anti-oxidant status in baker’s yeast, Saccharomyces cerevisiae at differentsodium selenite concentrations. Nutrition Hospitalaria, 21: 704-708.
Khodadadi, A., Arabzadeah, P., Rasouli, S., Moradpoor, A. and Abediyan, A. (2014). Survey of rainbow trout moetality in cage culture farms in Hasanloo Dam, West Azerbaijan province. Journal of Veterinary Clinical Pathology, 8(3): 461-522. [In Persian]
Khodadadi, A., Haghighi, A. and Nekoui Fard, A. (2017). Probiotic and prebiotic in aquaculture (with emphasis cold-water fishes). 1st ed., Tabriz: Parivar, pp: 1-52. [In Persian]
Kristiansen, M., Merrifield, D.L., Gonzalez Vecino, J.L., Myklebust, R. and Ringø, E. (2011). Evaluation of prebiotic and probiotic effects on the intestinal gut microbiota and histology of Atlantic salmon (Salmo salar L.). Journal of Aquaculture Research and Development, 9(S1): 1-8.
Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P.A., Moser, A.B., et al. (2003). Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology, 11: 720-726.
Merrifield, D.L., Dimitroglou, A., Foey, A., Davies, S.J., Baker, R.T.M., Bøgwald, J., et al. (2010). The current status and future focus of probiotic and prebiotic applications for salmonids. Aquaculture, 302: 1-18.
Merrifield, D.L., Harper, G., Mustafa, S., Carnevali, O., Picchietti, S. and Davies, S.J. (2011). Effect of dietary alginic acid on juvenile tilapia (Oreochromis niloticus) intestinal microbial balance, intestinal histology and growth performance. Cell and Tissue Research, 344: 135-146.
Merrifield, D.L. and Ringø, E. (2014). Aquaculture nutrition: gut health, probiotics, and prebiotics. 1st ed., Wiley Blackwell Publishes: Electronic Formats, pp: 125-500.
Nikoskelainen, S., Ouwehand, A., Salminen, S. and Bylund, G. (2001). Protection of rainbow trout (Oncorhynchus mykiss) from furunculosis by Lactobacillus rhamnosus. Aquaculture, 198 (3-4): 229-236.
Pérez, T., Balcázar, J.L., Ruiz-Zarzuela, I., Halaihel, N., Vendrell, D., de Blas, I., et al. (2010). Host–microbiota interactions within the fish intestinal ecosystem. Mucosal Immunology, 3: 355-360.
Pérez-Sánchez, T., Ruiz-Zarzuela, I., De Blas, I. and Balcázar, J.L. (2013). Probiotics in aquaculture: a current assessment. Reviews in Aquaculture, 10: 1-10.
Rayes, N., Seehofer, D., Theruvuth, T., Schiller, R.A., Langrehr, J.M., Jonus, S., et al. (2004). Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation—a randomized, double-blind trial. American Journal of Transplantation, 5: 125-130.
Rishi, P., Kaur Mari, S., Bharrhan, S., Shukla, G. and Rupinder, T. (2009). Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. FEMS Microbiology Ecology, 69: 222-230.
Roberts, R.J. (2001). The immunology of teleost. 1st ed., UK: London, W.B. Saunders, pp: 133-150.
Sealy, W.M., Barrows, F.T., Johansen, K.A., Overturf, K., LaPatra, S.E. and Hardy, R.W. (2007). Evaluation of the ability of partially autolysed yeast and Grobiotic-A to improve disease resistance in rainbow trout. North American Journal of Aquaculture, 69: 400-406.
Staykov, Y., Spring, P. and Denev, S. (2005). Influence of dietary Bio-Mos® on growth, survival and immune status of rainbow trout (Salmo gairdneri irideus G.) and common carp (Cyprinus carpio). In: Nutritional Biotechnology in the Feed and Food Industries. 1st ed., Nottingham University Press, pp: 333-343.
Staykov, Y., Spring, P., Denev, S. and Sweetman, J. (2007). Effect of a mannan oligosaccharide on the growth performance and immune status of rainbow trout (Oncorhynchus mykiss). Aquaculture International, 15: 153-161.
Taheri Mirghaed, A., Ebrahimzadeah, S.M., Nouri Mogehi, M.H. and Agahi, N. (2014). Colour Atlas of Fish Pathology. 1st ed., Iran: Tehran, Jahad Daneshgahi Publishes, pp: 111-302.
Tukmechi, A., Rahmati Andani, H.R., Manaffar, R. and Sheikhzadeh, N. (2011). Dietary administration of beta-mercapto-ethanol treated Saccharomyces cerevisiae enhanced the growth, innate immune response and disease resistance of the rainbow trout, Oncorhynchus mykiss. Fish Shellfish Immunology, 30: 923-928.
Yadav, M. and Schorey, J.S. (2006). The β-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood, 108: 3168-3175.
